The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Suzanne Schindler
Project Title: Development of a model for time of amyloid accumulation in Late Onset Alzheimer Disease (LOAD)
Date: December 21, 2021 at 5:18 pm
Request ID: D1802
Aim 1: To determine whether the model for change in SUVR as a function of SUVR can be further optimized by incorporating additional covariates (e.g. age, APOE e4 genotype)
Aim 2: To examine how other biomarkers change as a function of amyloid time, including CSF biomarkers, imaging biomarkers (structural brain MRI and tau PET) and cognitive measures.
Aim 3: To create a model for estimated time until dementia onset (EYO) in late onset AD using amyloid time and covariates known to affect risk for dementia, including age, gender, years of education, APOE 4 genotype, race and vascular risk factors.
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Investigator: Isabelle Bos
Project Title: The relationship between dementia risk factors and AD biomarkers in preclinical AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1803
Aim 1: investigate the association between AD biomarkers and common risk factors for dementia in cognitively normal individuals and their influence on cognitive decline.
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Investigator: Dr. Judy Pa
Project Title: Is CSF sPDGFRβ, a measure of vascular dysfunction, related to functional connectivity among brain regions associated with Alzheimer�s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1804
Aim 1: Determine if vascular impairment affects functional connectivity using rsfMRI data
Aim 2: use DWI data to determine if vascular impairment affects structural connectivity
Aim 3: determine a time line of events, does vascular impairment affect FC first versus SC
Aim 4: explore the relationship between clinical diagnosis, vascular impairment and functional connectivity
Investigator: Mony J de Leon
Project Title: CSF clearance in Alzheimer Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1805
Aim 1: CSF clearance in Alzheimer�s disease
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Investigator: Denise Head
Project Title: Spatial Navigation as a Predictor of Conversion to Symptomatic Alzheimer Disease and Cognitive Decline
Date: December 21, 2021 at 5:18 pm
Request ID: D1806
Aim 1: To determine whether baseline spatial navigation task performance is associated with conversion to symptomatic Alzheimer disease and/or cognitive decline.
Aim 2: We will compare the association of spatial navigation task performance with conversion to symptomatic AD and cognitive decline with other predictors of decline that have been previously studied: biomarkers, hippocampal volume, and psychometric measures.
Aim 3: We will examine whether spatial navigation performance predicts changes in Alzheimer biomarkers, hippocampal volume and/or psychometric measures.
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Investigator: Beau Ances MD & Tammie Benzinger MD
Project Title: F 18 T807 Tau PET Imaging of Older (≥ 50 years old) HIV Infected (HIV+) and HIV Uninfected (HIV-) Individuals (IND 123119, Protocol G)
Date: December 21, 2021 at 5:18 pm
Request ID: D1807
Aim 1: Perform human in vivo tau imaging using F 18 T807 in 30 older (≥ 50 years old) HIV+ participants and 30 HIV- controls. All 60 participants will have neuroimaging, neuropsychological performance testing, and a clinical examination at a visit.
Aim 2: Compare tau deposition in HIV+ individuals compared to HIV- individuals.
Aim 3: Correlate regional quantitative T807 binding potentials (BPs) with cognitive impairment, as documented by neuropsychological performance tests, in HIV+ and HIV- individuals.
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Investigator: Lindsay Farrer; Gyungah Jun
Project Title: Genomic and Biological Studies of APOE e2 in Alzheimer�s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1808
Aim 1: Conduct an AD GWAS among APOE ɛ2 carriers using HRC-imputed ADGC datasets to confirm preliminary association findings and identify new loci, and replicate top findings in independent samples.
Aim 2: Validate and identify new functional variants for AD-associated loci using whole exome and whole genome sequence data.
Aim 3: Perform pathway analyses to elucidate pathways and mechanisms linking genes to disease.
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Investigator: Anne Fagan
Project Title: Evaluation of alpha-synuclein in CSF of MAP participants who have come to autopsy
Date: December 21, 2021 at 5:18 pm
Request ID: D1809
Aim 1: evaluate the potential utility of measures of CSF aSN as a marker of underlying LB pathology in LOAD
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Investigator: None
Project Title: Impact of Race in Reported Memory Problem
Date: December 21, 2021 at 5:18 pm
Request ID: D1810
Aim 1: The primary aim is to determine whether the self-reported versus informant-reported memory problems in African American and Non-Hispanic White non-demented and very mildly of mildly demented Alzheimer disease (AD) individuals correlate with cognitive performance and progression of cognitive dysfunct
Aim 2: Secondary aim includes determining if there is any correlation or racial difference in self-reported and informant reported memory problems and psychometric testing.
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Investigator: GS Day
Project Title: Identifying Factors that Influence Participation in MAP CSF Biomarker Studies
Date: December 21, 2021 at 5:18 pm
Request ID: D1811
Aim 1: Identify participant-specific factors that influence participation in CSF biomarker studies in MAP participants.
Aim 2: Identify procedural factors that influence participation in CSF biomarker studies in MAP participants.
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