The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with AD progression rate
Date: December 21, 2021 at 5:18 pm
Request ID: D1320
Aim 1: Psychometric scores from the different test and contributed sites will be combined
Aim 2: A GWAS will be running using several psychometric test as endophentypes
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Investigator: CAMD consortium
Project Title: CAMD request for biomarker data
Date: December 21, 2021 at 5:18 pm
Request ID: D1319
Aim 1: FDA biomarker qualification
Aim 2: Alzheimer’s disease progression modeling
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Investigator: John C. Morris
Project Title: Investigating COMT and Intraindividual Variability
Date: December 21, 2021 at 5:18 pm
Request ID: D1304
Aim 1: Determine whether COMT is independently related to intraindividual variability in reaction time.
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Investigator: Anne Fagan and Maartje Kester
Project Title: APOE genotype and CSF biomarkers in predictive models for cognitive decline and Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1315
Aim 1: to look at the effect of APOE genotype on the diagnostic and prognostic ability of CSF biomarkers.
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Investigator: Beau Ances
Project Title: Comparing Functional Connectivity and CSF in Autosomal Dominant and Late Onset AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1316
Aim 1: Characterize relationship between CSF & functional connectivity in autosomal dominant AD (ADAD).
Aim 2: Compare relationship between CSF and FC for ADAD and late onset AD (LOAD).
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Investigator: Pau Pastor
Project Title: Clinical and neuroimaging characterization of Alzheimer TREM2 p.R47H carriers
Date: December 21, 2021 at 5:18 pm
Request ID: D1317
Aim 1: To compare clinical featuresof Alzheimer TREM2 p.R47H carriers vs noncarriers and ctrl
Aim 2: To compare neuroimaging features (MRI) by VBM of Alzheimer TREM2 p.R47H vs noncarriers and controls
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Investigator: Stephanie Vos
Project Title: Prevalence of amyloid pathology in healthy and cognitively impaired individuals
Date: December 21, 2021 at 5:18 pm
Request ID: D1318
Aim 1: To characterize amyloid prevalence according to baselin cognitive scores (CDR, MMSE, delayed recall)
Aim 2: To characterize amyloid prevalence according to age, apoE genotype
Aim 3: To characterize amyloid prevalence according to future cognitive scores (CDR, MMSE, delayed recall)
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Investigator: Julia Soscia
Project Title: An item-level analysis of frequently missed items on the Mini Mental State Exam (MMSE) in cognitively normal older adults and its relationship to future cognitive impairment.
Date: December 21, 2021 at 5:18 pm
Request ID: D1505
Aim 1: To determine which MMSE items predict future cognitive problems
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Investigator: Flemming Andersen
Project Title: PET/MR brain AC evaluation
Date: December 21, 2021 at 5:18 pm
Request ID: D1506
Aim 1: To evaluate promising PET/MR brain attenuation methods
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Investigator: Linda Larson-Prior
Project Title: Changes in Brain Network dynamics As An Index of Amyloid Status in Healthy Elders
Date: December 21, 2021 at 5:18 pm
Request ID: D1507
Aim 1: Under the hypothesis that cognitively normal individuals with either abnormal CSF protein levels of Ab/tau an imaging evidence of amyloid load will exhibit abnormalities in regional and spectral-band specific neuronal synchronization, we will collect high density electroencephalography (hd-EEG, 256
Aim 2: Under the hypothesis that early markers of impairment in working memory will manifest in frontal synchrony measured in the theta band as well as in network synchrony assessed using phase locking value, we will collect hdEEG as subjects perform a visual N-back working memory task that includes emotio
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