The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Gregory S Day
Project Title: Investigating Reliability in Reporting of Medical History in Knight ADRC Participants
Date: December 21, 2021 at 5:18 pm
Request ID: D1908
Aim 1: Determine the reliability of reported past medical history of stroke and diabetes in Knight ADRC participants.
Aim 2: Quantify the in􀃙?uence of measured variables on reliability in reporting of past medical history of stroke and diabetes in Knight ADRC participants.
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Investigator: C Karch, GS Day
Project Title: Molecular mechanisms of the central regulator of TREM2 dysfunction (Clinical Correlation Substudy)
Date: December 21, 2021 at 5:18 pm
Request ID: D1909
Aim 1: Define the effects of common MS4A4A variants on the clinical expression of AD and related dementias, and disease-associated biomarkers profiles.
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Investigator: Arthur Simen, Adam Schwarz
Project Title: Utility of a digital cognitive endpoint in early POC studies in AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1904
Aim 1: Assess patient compliance on the ARC app
Aim 2: Generate preliminary estimates of relationships between ARC measures and A/T/N biomarker classification
Aim 3: Generate preliminary estimates of how performance on the ARC app relates to performance on traditional paper and pencil cognitive measures, regional distribution of tau and/or CSF P-Tau and cortical atrophy measured at the same point in time
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Investigator: Dr Noel Faux
Project Title: Replicating and evaluating blood-based AD risk signatures
Date: December 21, 2021 at 5:18 pm
Request ID: D1903
Aim 1: To replicate our blood-based predictive models of CSF AB 1-42 and tau
Aim 2: To evaluate the prognostic and clinical utility of our blood-based predictive models
Aim 3: Determine the utility of genomic risk scores when predicting CSF biomarkers
Aim 4: Evaluate the ability to predict other CSF based biomarkers

Investigator: Yong Wang
Project Title: Tensor Analysis of BOLD Signals in Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1902
Aim 1: Characterize the white matter BOLD tensor in normal aging and AD
Aim 2: Evaluate the relationsihp between white matter BOLD tensor and cognitive status in AD
Aim 3: Characterize the gray matter BOLD tensor in normal aging and AD
Aim 4: Evalaute the regional BOLD tensor connectivity in normal aging and AD

Investigator: Cho-Yi Chen
Project Title: Reproduce the Results from Musiek et al. (2018): Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1901
Aim 1: Reproduce the results from Dr. Yo-El Lu’s paper in JAMA Neurology (Musiek et al., 2018) and apply the same methodology to our dataset.
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Investigator: Makoto Ishii
Project Title: Alterations in leptin signaling and the hypothalamus in Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1731
Aim 1: To determine in longitudinal studies if baseline levels of plasma leptin and related metabolic molecules are associated with increased risk of developing: 1) cognitive decline (CDR 0 to 0.5), 2) Alzheimer’s disease diagnosis, or 3) positive biomarkers for Alzheimer’s disease
Aim 2: To determine in longitudinal studies if baseline body weight or body mass index are associated with increased risk of developing: 1) cognitive decline (CDR 0 to 0.5), 2) Alzheimer’s disease diagnosis, or 3) positive biomarkers for Alzheimer’s disease
Aim 3: To determine whether alterations in baseline hypothalamic volume are evident in cognitively intact individuals with positive CSF biomarkers for Alzheimer’s disease
Aim 4: To determine in longitudinal studies if baseline hypothalamic volume are associated with increased risk of developing: 1) cognitive decline (CDR 0 to 0.5), 2) Alzheimer’s disease diagnosis, or 3) positive biomarkers for Alzheimer’s diseas

Investigator: Mark McAvoy
Project Title: Exploring global changes in the brain’s lateralized organization
Date: December 21, 2021 at 5:18 pm
Request ID: D1730
Aim 1: Examine the effects of age and dementia status on the brain’s global lateralization
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Investigator: Mark McAvoy
Project Title: Exploring mean global and local BOLD signals in healthy aging and dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1729
Aim 1: Compare the mean global signal with current biomarkers of disease pathology
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Investigator: Nico Dosenbach
Project Title: Associating neuroimaging markers of AD with healthy brain organization
Date: December 21, 2021 at 5:18 pm
Request ID: D1911
Aim 1: To determine whether PET images of Beta-Amyloid and Tau have a spatial brain distribution similar to the distribution of Default network substructures observed in healthy individuals
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