The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


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Investigator: Dave Balota
Project Title: Age Differences in Category Learning Strategies
Date: December 21, 2021 at 5:28 pm
Request ID: S1405
Aim 1: To determine whether individual differences in category learning strategies differ between younger and older adults.
Aim 2: To examine the relationship between the volume of brain regions and category learning strategies in healthy older adults.
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Investigator: Jo Ann Antenor-Dorsey
Project Title: Effect of Sleep on Aerobic Glycolysis and Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1310
Aim 1: Determine if sleep disruption is associated with changes in aerobic glycolysis in the default mode n
Aim 2: Determine if sleep disruption is associated A-beta plaque deposition in the default mode network
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Investigator: Dmitriy A Yablonskiy, PhD
Project Title: Quantitative Evaluation of Changes in the AD brain Using Advanced MRI
Date: December 21, 2021 at 5:28 pm
Request ID: S1309
Aim 1: see attached file
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Investigator: Denise Head
Project Title: Differential Effects of Stress on Brain Structure and Cognition in Healthy Older Adults
Date: December 21, 2021 at 5:28 pm
Request ID: S1308
Aim 1: Determine the differential influence of cumulative stress/HPA axis activity on brain regions
Aim 2: Determine the differential influence of cumulative stress/HPA axis activity on cognitive functions
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Investigator: Tammie Benzinger
Project Title: F 18 T807 Tau PET Imaging of Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1307
Aim 1: Perform human in vivo tau imaging using F 18 T807 (aka 18F-AV1451) in 100 participants age 18 and ol
Aim 2: Develop quantitative analysis methods for F 18 T807 PET scans.
Aim 3: Correlate regional quantitative T807 binding potentials (BPs) with (a) progression of cognitive impa
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Investigator: David Carr
Project Title: Theraputic effects of intransasally-administered insulin in adults with aMCI or mild AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1306
Aim 1: To examine the effects of intranasally-administered insulin (INI) on cognition in aMCI and AD
Aim 2: To examine the effects of INI on entorhinal cortex and hippocampal atrophy in aMCI and AD
Aim 3: To examine the effects of INI on CSF biomarkers in aMCI and AD
Aim 4: Exam global measures of cognitive performance over 12 months of INI treatment compared to placebo

Investigator: David Van Essen
Project Title: Lifespan Pilot Supplement for WashU-UMinn Human Connectome Project (HCP) Consortium
Date: December 21, 2021 at 5:28 pm
Request ID: S1305
Aim 1: To determine what modifications of current HCP procedures are needed for older adults
Aim 2: To compare data acquired by modified HCP methods to data from previous studies in older adults
Aim 3: To estimate effect sizes to inform group sizes needed to demonstrate age differences in connectivity
Aim 4: To pilot behavioral phenotyping inolder adults using NIH Toolbox and other HCP measures

Investigator: Mitchell Sommers
Project Title: False hearing and cognitive control in DAT
Date: December 21, 2021 at 5:28 pm
Request ID: S1304
Aim 1: Determine if impaired cognitive control in DAT affects response bias
Aim 2: Determine if individuals with DAT rely more on context for speech perception
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Investigator: Nupur Ghoshal/ Clay Semenkovich
Project Title: Clinical and Biomarker Characterization of Inherited Frontotemporal Dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1303
Aim 1: A cohort of FTD caused by mutation in MAPT and GRN will be established, cognitively characterized, a
Aim 2: Use plasma and CSF to establish tau biomarker profiles that are unique to presymptomatic individuals
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Investigator: yvette Sheline
Project Title: Escitalopram Effects on CSF AB Total Concentration
Date: December 21, 2021 at 5:28 pm
Request ID: S1302
Aim 1: Compared to controls, subjects who get the 20mg/dayx2wks will have lower CSF concentration of A-beta
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