The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Denise Head
Project Title: Differential Effects of Stress on Brain Structure and Cognition in Healthy Older Adults
Date: December 21, 2021 at 5:28 pm
Request ID: S1308
Aim 1: Determine the differential influence of cumulative stress/HPA axis activity on brain regions
Aim 2: Determine the differential influence of cumulative stress/HPA axis activity on cognitive functions
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Investigator: Dmitriy A Yablonskiy, PhD
Project Title: Quantitative Evaluation of Changes in the AD brain Using Advanced MRI
Date: December 21, 2021 at 5:28 pm
Request ID: S1309
Aim 1: see attached file
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Investigator: Jo Ann Antenor-Dorsey
Project Title: Effect of Sleep on Aerobic Glycolysis and Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1310
Aim 1: Determine if sleep disruption is associated with changes in aerobic glycolysis in the default mode n
Aim 2: Determine if sleep disruption is associated A-beta plaque deposition in the default mode network
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Investigator: Randall Bateman
Project Title: Anti-Amyloid Treatment in Asymtomatic Alzheimer’s Disease (A4 Study)
Date: December 21, 2021 at 5:28 pm
Request ID: S1311
Aim 1: Test the hypothesis that solanezumab, administered as an IV infusion at a dose of 400mg every 4 weeks for 3 years, will slow cognitive decine as compared with placebo in subjects with preclincial AD
Aim 2: To test the hypothesis taht solanezumab will slow the decline of preceived function and performance of everyday activities, as compared to placebo
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Investigator: John Morris and Matthew Gabel
Project Title: Disclosure of Individual Research Results in Alzheimer’s Disease: Perceptions of At-Risk Asymptomatic Participants
Date: December 21, 2021 at 5:28 pm
Request ID: S1401
Aim 1: Educate an experimental group and assess perceptions of and interest in disclosure.
Aim 2: Examine responses as a function of potential modifying factors (e.g. age, political ideology).
Aim 3: Examine how study subjects compare with a nationally representative sample on the survey.
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Investigator: David Balota
Project Title: Cognitive Training in Prospective Memory
Date: December 21, 2021 at 5:28 pm
Request ID: S1402
Aim 1: whether explicit instruction leads to transfer of learning for prospective memory
Aim 2: what type of prospective memory training participants that is most effective for transfer
Aim 3: whether the same training works for a CDR .05 sample
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Investigator: Julie Bugg
Project Title: Prospective Memory Commission Errors and Controlled Monitoring Processes in Healthy Aging and Early-Stage Alzheimer�s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1403
Aim 1: We aim to examine if two prospective memory outcomes (1) commission errors and (2) controlled monitoring ability distinguish older adults with very mild dementia from healthy older adults
Aim 2: We aim to examine the relationship between these prospective memory outcomes and regional brain volumes
Aim 3: We aim to examine the relationship between these prospective memory outcomes and hypertension
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Investigator: Alison Goate/Carlos Cruchaga
Project Title: Human cell models of dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1404
Aim 1: To obtain and culture dermal fibroblasts from individuals carrying causative mutations associated with dementias (MAPT, GRN, C9ORF72, Non-DIAN PSEN1)
Aim 2: To obtain and culture dermal fibroblasts from individuals carrying risk variants associated with dementias (PLD3, TREM2, UNC5C)
Aim 3: To generate induced pluripotent stem cells (iPSCs) from dermal fibroblasts carrying causative mutations or risk variants associated with dementias
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Investigator: Randall Bateman, Chihiro Sato
Project Title: Analysis of Tau Kinetics using Infusion of Stable Isotopes
Date: December 21, 2021 at 5:28 pm
Request ID: S1406
Aim 1: What is the Half Life of Tau in the Human Central Nervous System
Aim 2: Is CSF Tau increased due to over-production or under-clearance
Aim 3: Are Tau Kinetics altered in Alzheimer’s Disease
Aim 4: How much should Tau be modulated by drugs which Target Tau
Investigator: Nupur Ghoshal/ Clay Semenkovich
Project Title: Clinical and Biomarker Characterization of Inherited Frontotemporal Dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1303
Aim 1: A cohort of FTD caused by mutation in MAPT and GRN will be established, cognitively characterized, a
Aim 2: Use plasma and CSF to establish tau biomarker profiles that are unique to presymptomatic individuals
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