The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Beau Ances MD, PhD
Project Title: Chronic Co-Morbid Conditions in HIV+ U.S. Adults on Highly-Active Anti-Retroviral Therapy (HAART)
Date: December 21, 2021 at 5:28 pm
Request ID: S1103
Aim 1: To identify of HIV affects brain resting state functional connections
Aim 2: To identify if HIV accelerates brain aging in resting state functional connections
Aim 3: To identify if neuroHAART affects brain resting state functional connections
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Investigator: Beau Ances MD, PhD
Project Title: Neuroimaging Biomarkers of Rapidly Progressive Dementia: A Prospective and Retrospective Study
Date: December 21, 2021 at 5:28 pm
Request ID: S1104
Aim 1: Determine if MRI images can assist in the early diagnosis of rapidly progressive cognitive decline.
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Investigator: Nathaniel Lucena
Project Title: Brain and Self-Reported Navigation
Date: December 21, 2021 at 5:28 pm
Request ID: S1105
Aim 1: Does age predict self-reported navigation skill?
Aim 2: Does regional brain volume predict self-reported navigation skill?
Aim 3: Does brain volume mediate the relationship between age and navigation skill?
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Investigator: Alexandra Zaleta
Project Title: Perceived consequences of Alzheimer’s disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1106
Aim 1: Characterize perceived consequences of AD via interviews of participants with varying AD experience
Aim 2: Consolidate interview results into a measure of perceived consequences for use in a separate study
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Investigator: Ling Bei
Project Title: Analysis of Regionally Specfic Cataract Formation in Alzheimer’s Disease Patients
Date: December 21, 2021 at 5:28 pm
Request ID: S1107
Aim 1: Quantify regionally specfic cataract formation with the Scheimpflug camera in DAT patients
Aim 2: Compare the properties of cataracts in biomaker (+ and -) DAT patients vs. age-matched controls
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Investigator: Stefan Irion
Project Title: Generation of iPSCs from individuals with different APOE alleles to study AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1108
Aim 1: Derive fibroblasts from individuals with different APOE alleles
Aim 2: Generate iPSCs from APOE fibroblasts
Aim 3: Differentiate iPSCs into neuronal cell types
Aim 4: Develop disease releavnt assyas using differentiated cell types
Investigator: Samantha Allison
Project Title: Developing a Spatial Navigation-Related Task for Detecting Preclinical AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1502
Aim 1: Assess the diagnostic accuracy of five spatial navigation-related tasks
Aim 2: Assess the reliability of five spatial navigation-related tasks
Aim 3: Assess the validity of five spatial navigation-related tasks
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Investigator: John Morris
Project Title: Antecedent Biomarkers for AD; The Adult Children Study
Date: December 21, 2021 at 5:28 pm
Request ID: S1501
Aim 1: In the cross-sectional arm of this study we will determine the relationship across subjects of well-established risk factors for, and biomarkers of AD to measurements of regional circulation and metabolism (blood flow, aerobic glycolysis as well as total glucose and oxygen metabolism
Aim 2: In the longitudinal arm of this study we will determine the relationship of changes in clinical assessments and biomarkers of AD to changes in regional circulation and metabolism.
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Investigator: Randall Bateman, Chihiro Sato
Project Title: Analysis of Tau Kinetics using Infusion of Stable Isotopes
Date: December 21, 2021 at 5:28 pm
Request ID: S1406
Aim 1: What is the Half Life of Tau in the Human Central Nervous System
Aim 2: Is CSF Tau increased due to over-production or under-clearance
Aim 3: Are Tau Kinetics altered in Alzheimer’s Disease
Aim 4: How much should Tau be modulated by drugs which Target Tau
Investigator: Dave Balota
Project Title: Age Differences in Category Learning Strategies
Date: December 21, 2021 at 5:28 pm
Request ID: S1405
Aim 1: To determine whether individual differences in category learning strategies differ between younger and older adults.
Aim 2: To examine the relationship between the volume of brain regions and category learning strategies in healthy older adults.
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