The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Mitchell Sommers
Project Title: False hearing and cognitive control in DAT
Date: December 21, 2021 at 5:28 pm
Request ID: S1304
Aim 1: Determine if impaired cognitive control in DAT affects response bias
Aim 2: Determine if individuals with DAT rely more on context for speech perception
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Investigator: David Van Essen
Project Title: Lifespan Pilot Supplement for WashU-UMinn Human Connectome Project (HCP) Consortium
Date: December 21, 2021 at 5:28 pm
Request ID: S1305
Aim 1: To determine what modifications of current HCP procedures are needed for older adults
Aim 2: To compare data acquired by modified HCP methods to data from previous studies in older adults
Aim 3: To estimate effect sizes to inform group sizes needed to demonstrate age differences in connectivity
Aim 4: To pilot behavioral phenotyping inolder adults using NIH Toolbox and other HCP measures
Investigator: Jo Ann Antenor-Dorsey
Project Title: Effect of Sleep on Aerobic Glycolysis and Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1310
Aim 1: Determine if sleep disruption is associated with changes in aerobic glycolysis in the default mode n
Aim 2: Determine if sleep disruption is associated A-beta plaque deposition in the default mode network
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Investigator: Randall Bateman
Project Title: Anti-Amyloid Treatment in Asymtomatic Alzheimer’s Disease (A4 Study)
Date: December 21, 2021 at 5:28 pm
Request ID: S1311
Aim 1: Test the hypothesis that solanezumab, administered as an IV infusion at a dose of 400mg every 4 weeks for 3 years, will slow cognitive decine as compared with placebo in subjects with preclincial AD
Aim 2: To test the hypothesis taht solanezumab will slow the decline of preceived function and performance of everyday activities, as compared to placebo
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Investigator: John Morris and Matthew Gabel
Project Title: Disclosure of Individual Research Results in Alzheimer’s Disease: Perceptions of At-Risk Asymptomatic Participants
Date: December 21, 2021 at 5:28 pm
Request ID: S1401
Aim 1: Educate an experimental group and assess perceptions of and interest in disclosure.
Aim 2: Examine responses as a function of potential modifying factors (e.g. age, political ideology).
Aim 3: Examine how study subjects compare with a nationally representative sample on the survey.
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Investigator: David Balota
Project Title: Cognitive Training in Prospective Memory
Date: December 21, 2021 at 5:28 pm
Request ID: S1402
Aim 1: whether explicit instruction leads to transfer of learning for prospective memory
Aim 2: what type of prospective memory training participants that is most effective for transfer
Aim 3: whether the same training works for a CDR .05 sample
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Investigator: Julie Bugg
Project Title: Prospective Memory Commission Errors and Controlled Monitoring Processes in Healthy Aging and Early-Stage Alzheimer�s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1403
Aim 1: We aim to examine if two prospective memory outcomes (1) commission errors and (2) controlled monitoring ability distinguish older adults with very mild dementia from healthy older adults
Aim 2: We aim to examine the relationship between these prospective memory outcomes and regional brain volumes
Aim 3: We aim to examine the relationship between these prospective memory outcomes and hypertension
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Investigator: Alison Goate/Carlos Cruchaga
Project Title: Human cell models of dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1404
Aim 1: To obtain and culture dermal fibroblasts from individuals carrying causative mutations associated with dementias (MAPT, GRN, C9ORF72, Non-DIAN PSEN1)
Aim 2: To obtain and culture dermal fibroblasts from individuals carrying risk variants associated with dementias (PLD3, TREM2, UNC5C)
Aim 3: To generate induced pluripotent stem cells (iPSCs) from dermal fibroblasts carrying causative mutations or risk variants associated with dementias
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Investigator: Dave Balota
Project Title: Age Differences in Category Learning Strategies
Date: December 21, 2021 at 5:28 pm
Request ID: S1405
Aim 1: To determine whether individual differences in category learning strategies differ between younger and older adults.
Aim 2: To examine the relationship between the volume of brain regions and category learning strategies in healthy older adults.
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Investigator: yvette Sheline
Project Title: Escitalopram Effects on CSF AB Total Concentration
Date: December 21, 2021 at 5:28 pm
Request ID: S1302
Aim 1: Compared to controls, subjects who get the 20mg/dayx2wks will have lower CSF concentration of A-beta
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