The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Dr. Randall Bateman
Project Title: Evaluation of plasma tau and p-tau quantitation by mass spectrometry as biomarkers for differential diagnosis of AD and tauopathies
Date: December 21, 2021 at 5:28 pm
Request ID: S1807
Aim 1: Use targeted mass spectrometry to design assays measuring tau isoforms in human plasma.
Aim 2: Assess the plasma tau assay’s accuracy for predicting CSF amyloid beta status (positive/negative) and amyloid PET status (positive/negative).
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Investigator: Stephanie Schultz
Project Title: Physical Activity and Brain Metabolism Across Adulthood and Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1806
Aim 1: Identify physical activity characteristics that are associated with a �beneficial� brain metabolism biomarker profile in aging and AD
Aim 2: Assess both direct and indirect effects of physical activity on cognitive functioning while accounting for participants� levels of global or regional AG (mediator)
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Investigator: Jonathan Peelle & Mitch Sommers
Project Title: Hearing and speech in Alzheimer�s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1805
Aim 1: Validate a short hearing test using test-retest reliability in participants with CDRs of 0, 0.5, and 1
Aim 2: Conduct exploratory analyses between hearing, cognitive, and imaging data to support future grant applications
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Investigator: Jeffrey M. Zacks
Project Title: Everyday Memory in Aging and Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1702
Aim 1: Test the hypothesis that age and biomarkers for AD neuropathology are associated with impairments in the ability to notice and remember changes.
Aim 2: Use an experimental approach to test one potential mechanism: reduced fidelity of medial temporal activity patterns leading to impaired detection of discrepancy.
Aim 3: Attempt to remediate age- and AD-related memory deficits by enhancing elders� encoding of new events in relation to related previous events with a cuing procedure.
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Investigator: Jason Hassenstab
Project Title: Pilot Study: Ambulatory Cognitive Assessments
Date: December 21, 2021 at 5:28 pm
Request ID: S1610
Aim 1: Determine the feasibility and utility of ambulatory cognitive assessments using measurment burst design.
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Investigator: Ganesh Babulal
Project Title: Racial differences in Alzheimer�s disease biomarkers and driving behavior
Date: December 21, 2021 at 5:28 pm
Request ID: S1609
Aim 1: We will determine, in a sample of 60 older adults, aged 65 years and older, with normal baseline cognition (Clinical Dementia Rating of 0), whether there are differences in values of cerebrospinal fluid (CSF) biomarkers and imaging amyloid uptake between African Americans and Caucasians
Aim 2: In the same sample, we will examine whether there are differences in African Americans and Caucasians cross-sectionally and longitudinally in daily driving behavior using an in-vehicle recording device and on a road test
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Investigator: Eric McDade
Project Title: Cerebrovascular Reactivity in the Presence of Cerebral Amyloid and Cerebrovascular Disease:
Date: December 21, 2021 at 5:28 pm
Request ID: S1608
Aim 1: To explore the impact of cerebral amyloid on cerebrovascular reactivity
Aim 2: To explore the impact of age and vascular related comorbidities in the relationship of cerebrovascular reactivity and cerebral amyloid
Aim 3: To explore the the impact of cerebrovascular reactivity as a moderator of amyloid related cognitive impairment
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Investigator: B, Joy Snider (WU site)
Project Title: Protocol 221AD301 A phase 3 Multicenter, RCT to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer�s Disease (ENGAGE Study)
Date: December 21, 2021 at 5:28 pm
Request ID: S1607
Aim 1: Evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the CDR-SB score as compared with placebo in subjects with early AD.
Aim 2: Evaluate the efficacy of aducanumab on MMSE, ADAS-Cog13, ADCS-ADL
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Investigator: Beau M. Ances, MD, PhD
Project Title: Allzheimer Disease Neuroimaging Initiative 3 (ADNI3)
Date: December 21, 2021 at 5:28 pm
Request ID: S1606
Aim 1: To discover, optimize, standardize, and validate clinical trial measures and biomarkers used in AD research
Aim 2: To capture rates of decline on cognitive, global and functional tests and the rate of conversion to MCI or dementia due to AD.
Aim 3: Determine the longitudinal extent and rate of amyloid and tau deposition in PET Scans and longitudinal change of cerebral tau correlated and compared with other changes in cognition and biomarkers
Aim 4: Determine which clinical, cognitive and biomarker and imaging capture detection of treatment effects and measure cognitive decline for all groups with a focus on biomarkers and Tau.
Investigator: John C. Morris
Project Title: Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer�s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1701
Aim 1: To show that loss of blood-brain barrier (BBB) integrity links vascular injury to neuronal injury in AD
Aim 2: Examine temporal relationship between BBB permeability, cerebral blood flow (CBF) and white matter lesions
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