The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: John Morris and Matthew Gabel
Project Title: Disclosure of Individual Research Results in Alzheimer’s Disease: Perceptions of At-Risk Asymptomatic Participants
Date: December 21, 2021 at 5:28 pm
Request ID: S1401
Aim 1: Educate an experimental group and assess perceptions of and interest in disclosure.
Aim 2: Examine responses as a function of potential modifying factors (e.g. age, political ideology).
Aim 3: Examine how study subjects compare with a nationally representative sample on the survey.
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Investigator: David Balota
Project Title: Cognitive Training in Prospective Memory
Date: December 21, 2021 at 5:28 pm
Request ID: S1402
Aim 1: whether explicit instruction leads to transfer of learning for prospective memory
Aim 2: what type of prospective memory training participants that is most effective for transfer
Aim 3: whether the same training works for a CDR .05 sample
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Investigator: Samantha Allison
Project Title: Developing a Spatial Navigation-Related Task for Detecting Preclinical AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1502
Aim 1: Assess the diagnostic accuracy of five spatial navigation-related tasks
Aim 2: Assess the reliability of five spatial navigation-related tasks
Aim 3: Assess the validity of five spatial navigation-related tasks
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Investigator: John Morris
Project Title: Antecedent Biomarkers for AD; The Adult Children Study
Date: December 21, 2021 at 5:28 pm
Request ID: S1501
Aim 1: In the cross-sectional arm of this study we will determine the relationship across subjects of well-established risk factors for, and biomarkers of AD to measurements of regional circulation and metabolism (blood flow, aerobic glycolysis as well as total glucose and oxygen metabolism
Aim 2: In the longitudinal arm of this study we will determine the relationship of changes in clinical assessments and biomarkers of AD to changes in regional circulation and metabolism.
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Investigator: Catherine M. Roe
Project Title: Evaluating the feasibility of using a global positioning data acquisition system to assess driving safety and decline in older adults with and without preclinical Alzheimer disease.
Date: December 21, 2021 at 5:28 pm
Request ID: S1407
Aim 1: To examine the feasibility of, and to develop the methodology for, the use of GPDAS to capture everyday driving behavior.
Aim 2: To compare driving performance using GPDAS in 10 adults with preclinical AD and 10 adult without.
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Investigator: Randall Bateman, Chihiro Sato
Project Title: Analysis of Tau Kinetics using Infusion of Stable Isotopes
Date: December 21, 2021 at 5:28 pm
Request ID: S1406
Aim 1: What is the Half Life of Tau in the Human Central Nervous System
Aim 2: Is CSF Tau increased due to over-production or under-clearance
Aim 3: Are Tau Kinetics altered in Alzheimer’s Disease
Aim 4: How much should Tau be modulated by drugs which Target Tau
Investigator: Dave Balota
Project Title: Age Differences in Category Learning Strategies
Date: December 21, 2021 at 5:28 pm
Request ID: S1405
Aim 1: To determine whether individual differences in category learning strategies differ between younger and older adults.
Aim 2: To examine the relationship between the volume of brain regions and category learning strategies in healthy older adults.
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Investigator: Alison Goate/Carlos Cruchaga
Project Title: Human cell models of dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1404
Aim 1: To obtain and culture dermal fibroblasts from individuals carrying causative mutations associated with dementias (MAPT, GRN, C9ORF72, Non-DIAN PSEN1)
Aim 2: To obtain and culture dermal fibroblasts from individuals carrying risk variants associated with dementias (PLD3, TREM2, UNC5C)
Aim 3: To generate induced pluripotent stem cells (iPSCs) from dermal fibroblasts carrying causative mutations or risk variants associated with dementias
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Investigator: Julie Bugg
Project Title: Prospective Memory Commission Errors and Controlled Monitoring Processes in Healthy Aging and Early-Stage Alzheimer�s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1403
Aim 1: We aim to examine if two prospective memory outcomes (1) commission errors and (2) controlled monitoring ability distinguish older adults with very mild dementia from healthy older adults
Aim 2: We aim to examine the relationship between these prospective memory outcomes and regional brain volumes
Aim 3: We aim to examine the relationship between these prospective memory outcomes and hypertension
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Investigator: Stefan Irion
Project Title: Generation of iPSCs from individuals with different APOE alleles to study AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1108
Aim 1: Derive fibroblasts from individuals with different APOE alleles
Aim 2: Generate iPSCs from APOE fibroblasts
Aim 3: Differentiate iPSCs into neuronal cell types
Aim 4: Develop disease releavnt assyas using differentiated cell types