The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Morris/Benzinger
Project Title: Quantitative PET Imaging without Arterial Blood Sampling
Date: [293]
Request ID: S1013
Aim 1: To investigate the feasibility of image-based arterial input function (AIF) estimation.
Aim 2: To investigate the feasibility of quantification of amyloid-beta deposition using the estimated AIF
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Investigator: Mark E. Wheeler
Project Title: Neural mechanisms of perceptual memory decisions in mild cognitive impairment
Date: [293]
Request ID: S1012
Aim 1: Test whether parietal integrity affects performance in perceptual choice and recall tasks
Aim 2: Identify neural signals related to the integration of evidence over time.
Aim 3: Determine whether neural integration signals are affected in early stages of dementia
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Investigator: Mike Weiner (Awarded NIH Grant)
Project Title: Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI2)
Date: [293]
Request ID: S1011
Aim 1: Determine and define biomarkers which best predit future cognitive decline.
Aim 2: Determine biomarkers that can serve as outcome measures to quantify the rate of disease progression.
Aim 3: Define biomarker measures that can be used to develop the most effective clinical trial scenarios.
Aim 4: Validate diagnoses and imaging/biomarker measures through neuropath exam of ADNI participants.
Investigator: Denise Head
Project Title: Spatial Navigation Skills in Alzheimer’s Disease
Date: [293]
Request ID: S1010
Aim 1: compare navigational skills between nondemented and very mild AD groups
Aim 2: compare navigational skills between APOE e4+ and e4- groups
Aim 3: compare navigational skills between PIB+ and PIB- CDR=0 groups
Aim 4: examine associations between navigational skills and brain volumes
Investigator: David A. Balota
Project Title: Testing the Utility of Implementation Intentions in the Very Mildly Demented
Date: [293]
Request ID: S1009
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Investigator: Alyse Firtel/Mitchell Sommers
Project Title: Evaluating Auditory-Visual Speech Perception in Individuals diagnosed with Alzheimer’s Disease
Date: [293]
Request ID: S1008
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Investigator: David M. Holtzman
Project Title: Sleep and amyloid-beta
Date: [293]
Request ID: S1007
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Investigator: Jonathan L. Haines, Ph.D
Project Title: Genetic Epidemiology of Alzheimer’s Disease in African Americans
Date: [293]
Request ID: S1006
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Investigator: B. Joy Snider
Project Title: Protocol H8A-MC-LZAT Plasma Amyloid Beta Species after a Single Solanezumab Infusion in Nondemented
Date: [293]
Request ID: S1005
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Investigator: B. Joy Snider
Project Title: Protocol H6L-MC-LFBF-Open-Label Extension for Alzheimer’s Disease Patients Who Complete Semagacestat
Date: [293]
Request ID: S1004
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