The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Mitchell Sommers
Project Title: False hearing and cognitive control in DAT
Date: [293]
Request ID: S1304
Aim 1: Determine if impaired cognitive control in DAT affects response bias
Aim 2: Determine if individuals with DAT rely more on context for speech perception
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Investigator: Nupur Ghoshal/ Clay Semenkovich
Project Title: Clinical and Biomarker Characterization of Inherited Frontotemporal Dementia
Date: [293]
Request ID: S1303
Aim 1: A cohort of FTD caused by mutation in MAPT and GRN will be established, cognitively characterized, a
Aim 2: Use plasma and CSF to establish tau biomarker profiles that are unique to presymptomatic individuals
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Investigator: yvette Sheline
Project Title: Escitalopram Effects on CSF AB Total Concentration
Date: [293]
Request ID: S1302
Aim 1: Compared to controls, subjects who get the 20mg/dayx2wks will have lower CSF concentration of A-beta
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Investigator: Dr. David Kaufman
Project Title: Behavioral and Electrophysiological Correlates of Attentional Control Deficits in Early-Stage AD
Date: [293]
Request ID: S1301
Aim 1: Very mild AD will lead to a reduction in the maintenance of task context
Aim 2: Very mild AD will lead to altered neural activity associated with conflict processing
Aim 3: The aforementioned behavioral and electrophysiological correlates will be positively correlated
Aim 4:
Investigator: Andrea Denny
Project Title: Ethnic differences in willingness to assent to brain donation
Date: [293]
Request ID: S1208
Aim 1: What factors among ethnically diverse research participants influence brain donation?
Aim 2: What are differences among elders in ethnic groups in the likelihood to assent to brain donation?
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Investigator: Cathy Roe, PhD
Project Title: Driving Performance in Preclinical Alzheimer’s Disease
Date: [293]
Request ID: S1207
Aim 1: Is preclinical AD a risk factor for impaired driving both at baseline and at longitudinal follow-up?
Aim 2: Are cognitive reserve factors associated with driving performance at baseline and follow-up?
Aim 3: Are navigational impairments risk factors for impaired driving at baseline and folllow-up?
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Investigator: Randall Bateman
Project Title: DIAN-TU-001
Date: [293]
Request ID: S1206
Aim 1: test safety and efficacy of two disease-modifying treatments for dominantly inherited AD
Aim 2: test effects of treatments on biomarkers (CSF and imaging) in dominantly inherited AD
Aim 3: test cognitive measures in presymptomatic individuals in dominantly inherited AD
Aim 4: compare two amyloid imaging agents in dominantly inherited AD
Investigator: John C. Morris, Matthew Gabel
Project Title: Disclosure of Individual Research Results in AD: Perceptions of At-Risk Asymptomatic Participants
Date: [293]
Request ID: S1205
Aim 1: Develop a survey to assess participants’ interest in the disclosure of their individual results.
Aim 2: Educate the experimental group and reassess perceptions of and interest in disclosure.
Aim 3: Examine responses as a function of potential modifying factors (e.g. age, political ideology).
Aim 4: Examine how study subjects compare with a nationally representative sample on the survey.
Investigator: Randall J Bateman
Project Title: In Vivo metabolism of Amyloid-beta in human CSF; A blood isotope labeled amyloid-beta test for AD
Date: [293]
Request ID: S1203
Aim 1: To determine if CSF Aβ synthesis and/or clearance is altered in subjects with dementia of the Alzhei
Aim 2: The next step is to measure Aβ kinetics in blood using the SILK technique.
Aim 3: Propose to test the hypothesis that blood A Beta isoform kinetics are disturbed in AD.
Aim 4: 2011 Specific aim 1 will measure AB isoform production and clearance in blood using existing stable
Investigator: B. Joy Snider
Project Title: Tests: The new age of dementia diagnosis
Date: [293]
Request ID: S1204
Aim 1: Evaluate the impact of CSF biomarkers on clinician diagnosis
Aim 2: Evaluate the impact of CSF biomarkers on clinician confidence in diagnosis
Aim 3: Evaluate the impact of CSF biomarkers on clinician treatment plan
Aim 4: