The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Goate, Alison
Project Title: Genomic Search for Susceptibility to Alzheimer’s Disease
Date: December 21, 2021 at 5:29 pm
Request ID: S0004
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Investigator: Dromerick, Alexander W.
Project Title: Can the ISP be Used to Evaluate Mild Vascular Cognitive Impairment
Date: December 21, 2021 at 5:29 pm
Request ID: S0123
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Investigator: Elizabeth Mulligan
Project Title: Grief Among Dementia Caregivers: A Comparison of Two Assessment Systems
Date: December 21, 2021 at 5:29 pm
Request ID: S0905
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Investigator: B. Joy Snider
Project Title: Protocol H6L-MC-LFBF-Open-Label Extension for Alzheimer’s Disease Patients Who Complete Semagacestat
Date: December 21, 2021 at 5:29 pm
Request ID: S1004
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Investigator: Morris/Benzinger
Project Title: Amyloid-beta Deposition in Aging: Quantitative Comparison of Two Amyloid Imaging Agents
Date: December 21, 2021 at 5:29 pm
Request ID: S1014
Aim 1: To add beta-amyloid plaque imaging with PET using AV-45 to the longitudinal assessments to KARI.
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Investigator: Denise Head
Project Title: Spatial Navigation Skills in Alzheimer’s Disease
Date: December 21, 2021 at 5:29 pm
Request ID: S1010
Aim 1: compare navigational skills between nondemented and very mild AD groups
Aim 2: compare navigational skills between APOE e4+ and e4- groups
Aim 3: compare navigational skills between PIB+ and PIB- CDR=0 groups
Aim 4: examine associations between navigational skills and brain volumes
Investigator: Mike Weiner (Awarded NIH Grant)
Project Title: Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI2)
Date: December 21, 2021 at 5:29 pm
Request ID: S1011
Aim 1: Determine and define biomarkers which best predit future cognitive decline.
Aim 2: Determine biomarkers that can serve as outcome measures to quantify the rate of disease progression.
Aim 3: Define biomarker measures that can be used to develop the most effective clinical trial scenarios.
Aim 4: Validate diagnoses and imaging/biomarker measures through neuropath exam of ADNI participants.
Investigator: Mark E. Wheeler
Project Title: Neural mechanisms of perceptual memory decisions in mild cognitive impairment
Date: December 21, 2021 at 5:29 pm
Request ID: S1012
Aim 1: Test whether parietal integrity affects performance in perceptual choice and recall tasks
Aim 2: Identify neural signals related to the integration of evidence over time.
Aim 3: Determine whether neural integration signals are affected in early stages of dementia
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Investigator: Buckner, Randy L.
Project Title: fMRI Exploration of Memory and Aging and Early-Stage DAT
Date: December 21, 2021 at 5:29 pm
Request ID: S0107
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Investigator: Thomas M. Meuser
Project Title: Personal Meanings & Emotions in Life Space Mobility
Date: December 21, 2021 at 5:29 pm
Request ID: S0911
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