The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Timothy Miller, MD, PhD.
Project Title: Determining the half-life of SOD1 in the CSF
Date: [293]
Request ID: S1202
Aim 1: Determining the half-life of SOD1 in human CSF using stable isotope labeling kinectics
Aim 2: Development work in conjunction with Randy Bateman for determining half-life of TAU
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Investigator: Siekyeong Kim
Project Title: Alcohol use and brain functional connectivity
Date: [293]
Request ID: S1201
Aim 1: To ascertain the effect of alcohol on rs-fcMRI in cognitively normal middle aged and older adults
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Investigator: Stefan Irion
Project Title: Generation of iPSCs from individuals with different APOE alleles to study AD
Date: [293]
Request ID: S1108
Aim 1: Derive fibroblasts from individuals with different APOE alleles
Aim 2: Generate iPSCs from APOE fibroblasts
Aim 3: Differentiate iPSCs into neuronal cell types
Aim 4: Develop disease releavnt assyas using differentiated cell types
Investigator: Ling Bei
Project Title: Analysis of Regionally Specfic Cataract Formation in Alzheimer’s Disease Patients
Date: [293]
Request ID: S1107
Aim 1: Quantify regionally specfic cataract formation with the Scheimpflug camera in DAT patients
Aim 2: Compare the properties of cataracts in biomaker (+ and -) DAT patients vs. age-matched controls
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Investigator: Alexandra Zaleta
Project Title: Perceived consequences of Alzheimer’s disease
Date: [293]
Request ID: S1106
Aim 1: Characterize perceived consequences of AD via interviews of participants with varying AD experience
Aim 2: Consolidate interview results into a measure of perceived consequences for use in a separate study
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Investigator: Nathaniel Lucena
Project Title: Brain and Self-Reported Navigation
Date: [293]
Request ID: S1105
Aim 1: Does age predict self-reported navigation skill?
Aim 2: Does regional brain volume predict self-reported navigation skill?
Aim 3: Does brain volume mediate the relationship between age and navigation skill?
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Investigator: Beau Ances MD, PhD
Project Title: Neuroimaging Biomarkers of Rapidly Progressive Dementia: A Prospective and Retrospective Study
Date: [293]
Request ID: S1104
Aim 1: Determine if MRI images can assist in the early diagnosis of rapidly progressive cognitive decline.
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Investigator: Beau Ances MD, PhD
Project Title: Chronic Co-Morbid Conditions in HIV+ U.S. Adults on Highly-Active Anti-Retroviral Therapy (HAART)
Date: [293]
Request ID: S1103
Aim 1: To identify of HIV affects brain resting state functional connections
Aim 2: To identify if HIV accelerates brain aging in resting state functional connections
Aim 3: To identify if neuroHAART affects brain resting state functional connections
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Investigator: Dmitriy A Yablonskiy, PhD
Project Title: Quantitative Evaluation of Changes in the AD brain Using Advanced MRI
Date: [293]
Request ID: S1102
Aim 1: To compare GEPCI images obtained in five AD subjects with well-established disease with five normal age-matched subjects.
Aim 2: To compare qBOLD data obtained in five AD subjects with well-established disease with five normal age-matched subjects.
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Investigator: John Morris
Project Title: Changes in extracellular tau is driven by H1 and H2 tau haplotypes
Date: [293]
Request ID: S1101
Aim 1: To obtain and culture fibroblasts from non-demented controls expressing the H1/H2 tau haplotype
Aim 2: To measure extracellular tau in fibroblasts expressing the H1 or H2 tau haplotype
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