The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Timothy M. Miller
Project Title: Examining miRNAs in AD Patient CSF
Date: [208]
Request ID: T1106
Aim 1: Determine feasibility of measuring miRNAs in human CSF in AD vs. Control
Aim 2: Determine whether miRNA 155 is increased in AD patients vs. Control
Aim 3:
Aim 4:
Investigator: Michael Shelanski/John Crary
Project Title:
Date: [208]
Request ID: T1105
Aim 1: To identify biochemical alterations in tangle-only dementia
Aim 2: To identify genetic variants in tangle only dementia
Aim 3:
Aim 4:
Investigator: Jason Hassenstab
Project Title: Obesity, Insulin Sensitivity, and Functional Connectivity in Normal Aging
Date: [208]
Request ID: T1104
Aim 1: Do PIB- CDR 0’s with obesity and insulin resistance perform poorly on memory and exec. function?
Aim 2: Do PIB- CDR 0’s with obesity and insulin resistance have reduced functional connectivity?
Aim 3: Do PIB- CDR 0’s with obesity and insulin resistance have lower brain volumes/cortical thickness?
Aim 4:
Investigator: Illarion Turko
Project Title: Role of Oxysterols in Alzheimer’s Disease
Date: [208]
Request ID: T1103
Aim 1: Absolute quantification of cholesterol-metabolizing cytochrome P450s
Aim 2: Absolute quantification of sulfotransferases
Aim 3: Absolute quantification of proteins that are targets of oxysterol action
Aim 4:
Investigator: Cristina Tan Hehir
Project Title: Fluorophore that selectively binds soluble oligomers
Date: [208]
Request ID: T1102
Aim 1: To Investigate the value of measuring different forms of Aβ species in human brain tissue
Aim 2:
Aim 3:
Aim 4:
Investigator: William Z. Suo
Project Title: New strategy to fight selective cholinergic neuronal loss in Alzheimer’s disease
Date: [208]
Request ID: T1101
Aim 1: Determine if membrane G protein-coupled receptor kinase-5 (GRK5) deficiency is a feature of AD
Aim 2: Look for footprints of presynaptic M2 hyperactivity in basal forebrain cholinergic neurons in AD
Aim 3:
Aim 4:
Investigator: Jeffrey Zacks
Project Title: Encoding and remembering events across the lifespan
Date: [208]
Request ID: T1021
Aim 1: Does event segmentation predict event memory beyond that accounted for by clinical dementia status?
Aim 2: Is the segmentation-memory relationship mediated by changes in the prefrontal or posterior cortex?
Aim 3: Does event segmentation predict genetic indicators of Alzheimer’s disease (e.g., APOE4 status)?
Aim 4:
Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with cerebrospinal fluid granulin levels
Date: [208]
Request ID: T1020
Aim 1: To identify genetic variants associated with CSF GRN levels through a genome-wide association study
Aim 2:
Aim 3:
Aim 4:
Investigator: Huntington Potter
Project Title: Effect of immunotherapy on ACT and apoE binding to AD amyloid
Date: [208]
Request ID: T1019
Aim 1: Determine whether anti-amyloid immunotherapy changes level of antichymotyrpsin in plaques
Aim 2: Determine whether anti-amyloid immunotherapy changes level of apoE in plaques
Aim 3:
Aim 4:
Investigator: Ryan C. Bailey
Project Title: Development of a Scalable, Pre-clinical Alzheimer’s Diagnostic Panel Based upon Silicon Photonics
Date: [208]
Request ID: T1018
Aim 1: Validation of an emerging technology for pre-clinical AD diagnostics via multiplexed CSF proteomics
Aim 2:
Aim 3:
Aim 4: