The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Stefan Irion
Project Title: Generation of iPSCs from FTD patient to study AD and ALS disease biology
Date: [208]
Request ID: T1214
Aim 1: Generate iPSCs from FTD fibroblasts
Aim 2: Differentiate iPSCs into neuronal cell types and glia
Aim 3: Develop disease relevant assyas using differentiated cell types
Aim 4: Identify disease specific phenotypes and disease mechanisms
Investigator: Dougherty
Project Title: Screening for antigens present in hypothalamic neurons
Date: [208]
Request ID: T1213
Aim 1: Identify new antigens present in hypothalamic neurons
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Investigator: Ina Wanner
Project Title: Signature of astrocyte reactivity and injury in insult versus healthy brain cerebrospinal fluid, CSF
Date: [208]
Request ID: T1212
Aim 1: To compare the CSF proteome of insult versus healthy brain in their astrocytic signature
Aim 2: To measure levels of new astrocyte injury markers in insult versus healthy brain CSF
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Investigator: Brody
Project Title: Assessment of amyloid-beta oligomers with a novel assay
Date: [208]
Request ID: T1211
Aim 1: To assess amyloid-beta oligomers in additional patients and additional brain regions
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Investigator: Dr. John Hardy
Project Title: Genome wide association studies (GWAS) for Frontotemporal-dementia (FTD).
Date: [208]
Request ID: T1210
Aim 1: Identification of common variants associated with FTD
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Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with cerebrospinal fluid granulin levels (Amendment)
Date: [208]
Request ID: T1209
Aim 1: To identify genetic variants associated with CSF GRN levels through a genome-wide association study
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Investigator: Anne Fagan and Hideaki Bujo
Project Title: Soluble LR11 (sLR11) as a potential CSF biomarker of AD
Date: [208]
Request ID: T1207
Aim 1: Test ability of CSF sLR11 to distinguish cognitively normal individuals from DAT
Aim 2: Investigation the relationship between sLR11 and Ab42
Aim 3: Future: utility of sLR11 as a prognostic biomarker of future cognitive decline in CDR 0
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Investigator: Marc Diamond
Project Title: Testing for tau aggregate seeding activity in CSF as a possible AD biomarker
Date: [208]
Request ID: T1208
Aim 1: Test whether a novel tissue culture assay can detect tau aggregate seeds specifically in AD samples
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Investigator: Stephen Graves, John Kauwe
Project Title: Serum Biomarkers for Alzheimer’s disease
Date: [208]
Request ID: T1206
Aim 1: To validate putative serum biomarkers in an independent series.
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Investigator: Joel Perlmutter, MD
Project Title: Use of PIB Imaging to Evaluate Dementia Subtypes in People with Parkinson Disease
Date: [208]
Request ID: T1205
Aim 1: To determine whether or not Alzheimer and Lewy body dementia have different cortical PIB uptake
Aim 2: To determine whether or not PIB uptake correlates with the presence of symptoms in AD and Lewy body.
Aim 3: To determine whether or not Amyloid Beta, Tau and Alpha Synuclein are present in the spinal fluid.
Aim 4: To determine whether elevated PIB uptake identifes a population most at risk for dementia.