The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Robert Siman
Project Title: A panel of neurodegeneration biomarkers for Alzheimer’s progression
Date: [208]
Request ID: T1204
Aim 1: Evaluate CSF levels of 7 neurodegeneration biomarkers in relation to neurocognitive status
Aim 2: Compare CSF neurodegeneration biomarker levels with biomarker evidence for AD neuropathology
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Investigator: Randall J Bateman
Project Title: Amyloid-Beta Metabolism in Familial Adult Children Study
Date: [208]
Request ID: T1203
Aim 1: Measure production rates of Amyloid-beta protein isoforms in mutation carriers
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Investigator: Dr. John Hardy
Project Title: Whole-exome sequencing of autopsy confirmed samples to identify rare variants implicated on AD
Date: [208]
Request ID: T1201
Aim 1: The aim of this study is to identify rare alleles of large effects on risk for Alzheimer’s Disease
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Investigator: Tim West, PhD
Project Title: Test Performance of a Novel Multiplex Assay to Quantify AD Biomarkers Within Cerebrospinal Fluid
Date: [208]
Request ID: T1113
Aim 1: Correlate concentrations measured by ELISA and SISAQ for Tau and Aβ 40 and 42
Aim 2: Compare the reproducibility of ELISA measures with SISAQ measures
Aim 3: Measure how well SISAQ measures distinguish individuals with disease pathology from those without
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Investigator: Paul Kotzbauer
Project Title: Neurochemical Correlates of Cognitive Phenotypes of Parkinson Disease
Date: [208]
Request ID: T1112
Aim 1: To determine whether regional neurotransmitter deficits correlate with cognitive phenotypes in PDe
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Investigator: Oscar Alzate
Project Title: Biomarkers of Alzheimer’s disease
Date: [208]
Request ID: T1111
Aim 1: To identify differential regulation of protein isoforms of APO family of proteins
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Investigator: Wyss-Coray
Project Title: The plasma proteome of secreted signaling proteins in people with pathological biomarkers for AD
Date: [208]
Request ID: T1110
Aim 1: To measure the plasma communicome associated with amyloid-positivity in cognitively normal individua
Aim 2: To discover biological pathways associated with amyloid-positivity in cognitively normals
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Investigator: Tapan Kumar Khan
Project Title: Activated Erk1 and Erk2 in the cerebrospinal fluid of Alzheimer’s disease patients
Date: [208]
Request ID: T1109
Aim 1: Measure Erk phosphorylation in CSF.
Aim 2: Determine the pathologic relevance of Erk phosphorylation in AD
Aim 3: Assess other kinases as potential CSF biomarkers of AD
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Investigator: Cruchaga
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Date: [208]
Request ID: T1108
Aim 1: to identify the causative variant of Kufs’ disease
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Investigator: Kelly R. Bales in collaboration with David Holtzman
Project Title: 5HT4 expression survey
Date: [208]
Request ID: T1107
Aim 1: Determine level of 5HT4 mRNA (including splice variants) in brain tissue from CDR 0, 0.5, 1 and >1
Aim 2: Determine the level of 5HT4 protein in brain tissue from CDR 0, 0.5, 1 and >1
Aim 3: Determine the level of 5HT4 agonist binding in brain tissue from CDR 0, 0.5, 1 and >1
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