The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Alison Goate/Carlos Cruchaga
Project Title: Identification of rare variants implicated on Alzheimer’s Disease
Date: [208]
Request ID: T1224
Aim 1: Identification of rare variants implicated on Alzheimer’s Disease
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Investigator: Stephen is the PI of the UL grant; Wingo is the PI of the URC/ASCTI grant
Project Title: Autosomal Recessive Causes of Early-onset Alzheimer’s Disease
Date: [208]
Request ID: T1223
Aim 1: Our overarching aim is to test the hypothesis that early-onset Alzheimer’s disease (AD) has autosoma
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Investigator: Elliott Mufson
Project Title: CSF proNGF: a putative biomarker for Alzheimer’s disease
Date: [208]
Request ID: T1222
Aim 1: We will test whether CSF levels of proNGF are predicitve or prodromal AD.
Aim 2: Test whether CSF proNGF levels improve the diagnostic accuracy of CSF tau/Abeta
Aim 3: Test whether CSF proNGF levels correlate with antemortem measures of cognitive decline.
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Investigator: Anja Schneider/Andre Fischer
Project Title: Genome-wide profiling of CSF miRNA expression in antecedent AD using next generatio
Date: [208]
Request ID: T1221
Aim 1: next generation deep sequencing of CSF miRNAome
Aim 2: Identification of antecedent miRNA biomarkers to predict later AD
Aim 3: Identify longitudinal changes in CSF miRNAome accompagnying preclinical AD
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Investigator: Jose Bras
Project Title: Role of Genomic variability in Lewy Body dementia
Date: [208]
Request ID: T1220
Aim 1: Identification of genetic variability conferring risk for DLB
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Investigator: Yan Zhang
Project Title: Ankyrin G levels in AD tissues
Date: [208]
Request ID: T1219
Aim 1: The levels of Ankyrin G will be measured in control and AD tissues
Aim 2: To confirm if Ankyrin G is downregulated in AD brains
Aim 3: Search for mechanism of Ankyrin G downregulation in AD
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Investigator: G. William Rebeck
Project Title: Early effects of APOE genotype on brain function
Date: [208]
Request ID: T1218
Aim 1: Determine if APOE genotype affects CSF levels of neuronal metabolites
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Investigator: Stephen M. Strittmatter
Project Title: Measuring Levels of Amyloid Beta Oligomers Capable of PrP Interaction
Date: [208]
Request ID: T1217
Aim 1: Use Novel Assay to Measure PrP-Interacting Aβ Oligomers in AD versus Control Samples
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Investigator: Luke Chamberlain
Project Title: Analysis of Biochemical Properties of Cysteine-String Protein Mutants in Kufs’ Disease
Date: [208]
Request ID: T1216
Aim 1: Analysis of Biochemical Properties of Cysteine-String Protein Mutants in Kufs’ Disease
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Investigator: Nigel J. Cairns
Project Title: Poly(ADP-ribose) accumulation in frontotemporal lobar degeneration with TDP proteinopathy
Date: [208]
Request ID: T1215
Aim 1: To determine the role of PAR in the pathogenesis of FTLD-TDP
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