The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Sidney Strickland
Project Title: Investigation of a prothrombotic state in AD patient plasma
Date: [208]
Request ID: T1306
Aim 1: Determine if AD patient plasma exhibits accelerated clot formation compared to control plasma
Aim 2: Determine if AD patient plasma exhibits accelerated and increased thrombin generation
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Investigator: Vijay Sharma
Project Title: Novel PET Tracer for Imaging Amyloid β in the Brain
Date: [208]
Request ID: T1305
Aim 1: To determine specificity of the agent for amyloid β compared to other biomarkers
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Investigator: John Morris
Project Title: sLR11 as a potential CSF biomarker of AD (amendment to T1207)
Date: [208]
Request ID: T1207-A
Aim 1: to characterize the staining distribution of LR11 in control, AD and non-AD brain
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Investigator: Marc I. Diamond
Project Title: Identification of novel anti-tau antibodies capable of blocking tau propagation
Date: [208]
Request ID: T1304
Aim 1: To test whether novel anti-tau antibodies can block tau seeding induced by human brain lysate
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Investigator: Chadwick Hales
Project Title: RNA splicing dysfunction in familial AD.
Date: [208]
Request ID: T1303
Aim 1: To study RNA splicing in familial AD cell lines, IPS cells, and derived neurons.
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Investigator: David L. Brody
Project Title: PrP-interacting Aβ oligomers in Human Cortical Lysates
Date: [208]
Request ID: T1302
Aim 1: Determine the correlation between PrP interacting amyloid beta oligomers and clinical symptoms.
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Investigator: Philip B. Verghese
Project Title: Amendment to “Apolipoprotein E Isoforms and Aβ Metabolism (T1005)”
Date: [208]
Request ID: T1005-A
Aim 1: Characterize the CNS apoE isoform-associated proteome and lipidome in normal and AD subjects
Aim 2: Determine how lipids and proteins of apoE isoforms modulate apoE functions
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Investigator: Alison Goate
Project Title: Defining the mechanisms of AD pathogenesis in human IPSC-derived neurons
Date: [208]
Request ID: T1301
Aim 1: To measure the influence of pathogenic FAD mutations on APP and tau metabolism in human neurons
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Investigator: Berislav V Zlokovic
Project Title: Pericyte deficiency and blood-brain barrier breakdown in various Alzheimer’s disease APOE genotypes
Date: [208]
Request ID: T1230
Aim 1: To determine the effects of APOE genotype on blood-brain barrier permeability in AD
Aim 2: To determine the effects of APOE genotype on pericyte coverage and number in AD
Aim 3: Investigate cell-specific distribution and levels of LRP-1 and MMP-9 in AD
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Investigator: Berislav V. Zlokovic
Project Title: CSF BIOMARKERS OF BLOOD-BRAIN BARRIER BREAKDOWN IN COGNITIVELY NORMAL AND ALZHEIMER’S INDIVIDUALS
Date: [208]
Request ID: T1234
Aim 1: TO DETERMINE THE EFFECTS OF APOE GENOTYPE ON CSF MARKERS OF BBB BREAKDOWN IN COGNITIVELY NORMAL
Aim 2: TO DETERMINE THE EFFECTS OF APOE GENOTYPE ON CSF MARKERS OF BBB BREAKDOWN IN MILD AND SEVERE AD
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