The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Matthew Harms
Project Title: Tissue heterogeneity of the C9ORF72 expansion in carriers
Date: [208]
Request ID: T1233
Aim 1: Characterize differences the C9 repeat expansion between tissue types (brain vs non-brain)
Aim 2: Characterize differences the C9 repeat expansion between brain regions
Aim 3: Correlate tissue expansion sizes with C9 expression levels
Aim 4: Correlate tissue expansion sizes with neuropathological features
Investigator: Stephen Chou
Project Title: Sample Request for Performance Testing of Ultrasensitive Immunoassay in Detecting Beta Amyloid in Pl
Date: [208]
Request ID: T1232
Aim 1: Performance Testing of Ultrasensitive Immunoassay in Detecting Beta Amyloid in Plasma
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Investigator: Kenneth Kosik
Project Title: Gene expression analysis of MAPT A152T mutation carriers
Date: [208]
Request ID: T1231
Aim 1: Transcriptome sequencing of RNA obtained from patients’ samples.
Aim 2: Comparison of differentially express genes compared to human healthy tissue.
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Investigator: Nikolaos Robakis
Project Title: Correlation of microRNA and protein expression in AD brains
Date: [208]
Request ID: T1229
Aim 1: Levels of neuronal microRNAs and target proteins, including PEA-15 and EphB2 in AD brains.
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Investigator: TERESA GOMEZ-ISLA
Project Title: Dissecting molecular mechanisms involved in human brain resilience to Alzheimer’s pathology
Date: [208]
Request ID: T1228
Aim 1: Are some human brains resistant to AD pathology (amyloid plaques and neurofibrillary tangles)?
Aim 2: What are the neuroprotective mechanisms involved?
Aim 3: Is the Abeta/tau phenotype what determines structural damage and impaired cognition in AD?
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Investigator: Steven Schreiber, MD
Project Title: Histone deacetylase activity in Alzheimer’s disease
Date: [208]
Request ID: –
Aim 1: To evaluate HDAC activity and abundance in CSF from AD, MCI, age-matched controls
Aim 2: To determine whether there is a correlation between CSF HDAC activity and clinical features
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Investigator: Holly D. Soares
Project Title: Development of IVD CSF AB42 and Tau Assays
Date: [208]
Request ID: T1227
Aim 1: Aim 1: To define normative ranges in cognitively normal individuals who have remained cognitively n
Aim 2: Aim 2: To define assay specific cutpoints for cognitively impaired individuals at risk of progressi
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Investigator: G. William Rebeck
Project Title: Early Effects of APOE genotype on brain function
Date: [208]
Request ID: T1218-A
Aim 1: Identify CSF biomarkers of AD risk
Aim 2: Measure levels of neurotransmitters in CSF
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Investigator: John C. Morris/Jungsu Kim
Project Title: MicroRNA biomarkers for early detection of Alzheimer’s disease
Date: [208]
Request ID: T1226
Aim 1: Identification of cerebrospinal fluid miRNA biomarkers for early detection of AD
Aim 2: Identification of plasma miRNA biomarkers for early detection of AD
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Investigator: Carlos Cruchaga, Celeste Karch
Project Title: Identification of rare variants implicated on Alzheimer’s Disease
Date: [208]
Request ID: T1225
Aim 1: To identify genes deferentially expressed in AD brains compared to controls
Aim 2: To identify proteins with different levels in AD brains compared to controls
Aim 3: To identify genetic variants associated with gene expression
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