The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Jin Moo Lee
Project Title: ICH GWAS
Date: [208]
Request ID: T1316
Aim 1: GWAS analysis for primary hemorrhage
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Investigator: Laila Abdullah
Project Title: Use of lipidomics to identify biomarkers of mild cognitive impairment and Alzheimer’s disease
Date: [208]
Request ID: T1315
Aim 1: To determine if CSF lipid profiles correlate with PIB imaging-based brain amyloid burden
Aim 2: To determine if lipid profiles can diagnostically differentiate MCI and AD patients from controls
Aim 3: To determine if lipid profiles can enhance the accuracy of PIB imaging in diagnosing MCI/AD
Aim 4:
Investigator: Kauwe
Project Title: Association between Toxoplasma gondii infection and Alzheimer’s disease
Date: [208]
Request ID: T1314
Aim 1: To determine the prevalence of latent infection with T. gondii in AD cases vs. non-demented
Aim 2: To determine the relationship between T. gondii and cognitive outcome in AD and in normal aging
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Investigator: Richard Perrin
Project Title: CSF Biomarker Discovery for AD vs PDD
Date: [208]
Request ID: T1313
Aim 1: To compare CSF Ab42 and CSF tau expression profiles and their cutpoints for PIB positive vs. PIB neg
Aim 2: To compare CSF Ab42 and CSF tau expression across the following groups: CDR 0 (normal vs PD), CDR 0.
Aim 3: To compare ‘novel’ CSF biomarkers between Knight ADRC and WU PD cohorts, categorized by CDR and ‘AD
Aim 4: To compare many ‘novel’ CSF biomarkers across different platforms: Rules Based Medicine vs. MSD vs (
Investigator: Rebeck GW
Project Title: Lipoprotein metabolism in human CSF depending on AD pathology and apoE genotype.
Date: [208]
Request ID: T1312
Aim 1: Analysis of apoE fragments and dimers in CSF samples of AD patients and controls
Aim 2: Investigate influence of genotype on apoE fragments and apoE dimers in human CSF
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Investigator: David Brody
Project Title: Detailed Characterization of Amyloid-beta Oligomers in Human Alzheimer Disease Brains
Date: [208]
Request ID: T1311
Aim 1: To purify multiple forms of Aβ oligomers from water-soluble lysates of human AD brains
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Investigator: JC Morris
Project Title: Internal Controls and ISR Program for use in clinical trials
Date: [208]
Request ID: T1309
Aim 1: To create pools of CSF to be used for Incurred Sample Reanalysis (ISR) in clinical trials
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Investigator: David W. Colby
Project Title: Detection and Structural Analysis of Tau Protein in Neurodegenerative Disease
Date: [208]
Request ID: T1310
Aim 1: Detect misfolded tau in Alzheimers Disease CSF by Amyloid Seeding Assay
Aim 2: Analysis of in vitro structural propagation of tau conformers from AD CSF
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Investigator: Carlos Cruchga
Project Title: Identification of novel CSF endophenotypes and genetic variants for AD by Mendelian Randomization
Date: [208]
Request ID: T1308
Aim 1: To analyze whether cerebrospinal fluid CLU, APOE and ACE levels are informative AD endophenotypes
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Investigator: TAE SUNG LIM
Project Title: Dementia of the Alzheimer’s type in Autopsy-Proven Corticobasal Degeneration
Date: [208]
Request ID: T1307
Aim 1: to compare the longitudinal course of clinical and psychometric features of 18 CBD and 18 matched AD
Aim 2: to evaluate the co-existence of other neurodegenerative proteinopathies using immunohistochemistry
Aim 3: to evaluate the contribution of other neurodegenerative proteinopathies to the clinical features.
Aim 4: