The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Laura Piccio and Carlos Cruchaga
Project Title: TREM2 as a key player and a potential biomarker in Alzheimer’s disease.
Date: [208]
Request ID: –
Aim 1: To determine whether the CSF and serum levels of sTREM2 are associated with clinical AD and/or with a TREM2-variant carrier status.
Aim 2:
Aim 3:
Aim 4:
Investigator: Gregory J. Zipfel
Project Title: STAT3 activation and neurovascular dysfunction in Alzheimer’s disease
Date: [208]
Request ID: T1409
Aim 1: We plan to study the phosphorylation and acetylation of STAT3 in the blood vessels isolated from human AD brains
Aim 2:
Aim 3:
Aim 4:
Investigator: Ina B. Wanner
Project Title: Astroglia protein release as biofluid markers of neurodegeneration
Date: [208]
Request ID: T1212-A
Aim 1: Determine significance of elevated astroglia marker protein release between Control and TBI patients’ CSF and plasma
Aim 2: Pilot study to determine whether astrocyte release markers are elevated in AD versus Control CSF and plasma
Aim 3:
Aim 4:
Investigator: Ronald DeMattos
Project Title: Analyses of Full-Length, Truncated, and Modified Aβ Species across the Alzheimer’s Disease Spectrum
Date: [208]
Request ID: T1408
Aim 1: Quantify the multiple forms of deposited Aβ that arise throughout the disease cascade (from normal through moderate stages of disease)
Aim 2:
Aim 3:
Aim 4:
Investigator: Kenneth S. Kosik
Project Title: Gene expression analysis of MAPT mutation carriers
Date: [208]
Request ID: T1407
Aim 1: Transcriptome sequencing for RNA obtained from neurons derived from iPS patients
Aim 2: Comparison of differentially expressed genes compared to human healthy lines and tissue
Aim 3: miRNA profiling of these samples as in 1
Aim 4: Determination of coexpression modules associated with the MAPT mutations
Investigator: Dr. Tom Montine
Project Title: : Neuropathological assessments of fibrillar amyloid burden in APOE e4 carriers and non-carriers with the clinical diagnosis of Alzheimer’s dementia
Date: [208]
Request ID: T1406
Aim 1: . In this study, NACC data will be used to compare the proportions of expired brain donors with the clinical diagnosis of Alzheimer’s dementia in terms of their fibrillar amyloid burden and other neuropathologic features
Aim 2:
Aim 3:
Aim 4:
Investigator: Eric J Kremer
Project Title: Screen for a biomarker in early satges of late-onset AD
Date: [208]
Request ID: T1405
Aim 1: Screen CSF from AD patients for the presence of a cleaved presynaptic protein diminished in early satges of late onset AD
Aim 2: Screen AD SGZ for the presence of a cell adhesion molecule diminished in early satges of late onset AD
Aim 3:
Aim 4:
Investigator: Cruchaga/Sands
Project Title: Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance (Amendment)
Date: [208]
Request ID: T1108-A
Aim 1: to identify the causative variant of Kufs’ disease
Aim 2: to characterize the causative mutations
Aim 3:
Aim 4:
Investigator: Kukull (Penn)
Project Title: Validation of non-amyloid, non-Tau CSF biomarkers of Alzheimer’s disease
Date: [208]
Request ID: T1403
Aim 1: Aim 1: We will validate 12 non-amyloid, non-Tau CSF biomarkers of AD in samples from subjects with normal cognition, AD, and non-AD dementias, longitudinally followed at the three Centers (WU, Penn, Emory).
Aim 2: Aim 2: We will identify non-amyloid, non-Tau biomarkers suitable as staging and progression biomarkers in AD, evaluate their specificity for AD vs non-AD dementias, and evaluate the technical variability of the relevant assays across three independent Centers.
Aim 3:
Aim 4:
Investigator: Mathew Blurton-Jones
Project Title:
Date: [208]
Request ID: T1404
Aim 1: Generation, gene-correction, and microglial differentiation of iPSC clones from patients with the AD-associated R47H TREM2 mutation.
Aim 2: Do mutations in TREM2 alter the activation state, migration, or phagocytic activity of human microglia?
Aim 3: Do TREM2 mutations alter microglial function and modulate Abeta and tau pathology in vivo?
Aim 4: