The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Celeste Karch
Project Title: PLD3 function in the lysosome
Date: [208]
Request ID: T1413-A
Aim 1: To determine whether PLD3 risk variants alter PLD3 localization and/or lysosomal function in human brains
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Investigator: Kelvin Yamada
Project Title: CSF orexin in postmenopausal insomnia
Date: [208]
Request ID: T1502
Aim 1: Determine if CSF orexin is elevated in postmenopausal women
Aim 2: Determine if CSF orexin levels by ELISA are accurately reflected by serum orexin levels
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Investigator: Rosa Rademakers
Project Title: Identification of new genetic causes of Early Onset Alzheimer Disease
Date: [208]
Request ID: T1501
Aim 1: Genetic screening of early onset alzheimer disease patients
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Investigator: Marni Uger PhD
Project Title: CSF Abeta oligomer quantification by EP-AD, a novel proprietary assay
Date: [208]
Request ID: T1425
Aim 1: EP-AD CSF oligomers in AD, MCI and cognitively normal aging
Aim 2: EP-AD CSF oligomer concentration and cognitive, imaging, and biochemical biomarker correlation
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Investigator: John A. Kessler
Project Title: Cell autonomous mechanisms of Apolipoprotein E isoform-dependent neurodegeneration
Date: [208]
Request ID: T1424
Aim 1: Generate isogenic APOE iPSCs from sporadic AD patients and healthy controls.
Aim 2: Evaluate whether calcium dysregulation contributes to increased excitotoxic response in E4- BFCNs.
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Investigator: Daojing Wang
Project Title: AD-MS Chips for Biofluids-Based Diagnosis of Alzheimer’s Disease
Date: [208]
Request ID: T1423
Aim 1: Validate proteoforms as a potential biomarker for early diagnosis of AD
Aim 2: Discover new biomarkers through a multi-omics strategy for early diagnosis of AD
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Investigator: Francis Hane
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Date: [208]
Request ID: 1422
Aim 1: Quantifying binding of affinity tags to amyloid oligomers
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Investigator: Erin H. Norris
Project Title: Pathological consequences of hypertension in Alzheimer’s disease
Date: [208]
Request ID: T1421
Aim 1: Identify molecular changes at the neurovascular unit in hypertensive humans with AD
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Investigator: Celeste Karch
Project Title: Identification of Common Targets in Human MAPT Mutation Carriers
Date: [208]
Request ID: T1420
Aim 1: To define the pathways disrupted in human brain tissue and human neurons from MAPT mutation carriers.
Aim 2: To define the pathways disrupted in human CSF and media from human neurons from MAPT mutation carriers.
Aim 3: To define the tau-specific modifications in human CSF, brain tissue, and neurons from MAPT mutation carriers.
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Investigator: David Holtzman
Project Title: The effects of TREM2 variants on plaque-associated microglia in Alzheimer’s disease
Date: [208]
Request ID: T1419
Aim 1: Assess the size, number, and percent area covered by plaque associated microglia in carriers and non-carriers of TREM2 variants associated with Alzheimer’s disease
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