The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: RJ Bateman
Project Title: Bioanalytical Assay Method Validation for Alzheimer�s Disease Clinical Trials
Date: [208]
Request ID: T1418
Aim 1: To create pools of CSF to be used to conduct full bioanalytical method validation on the INNO-BIA AlzBio3 assay for use in clinical trials
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Investigator: Perrin, Richard
Project Title: Novel CSF Biomarkers in Dominantly Inherited and Sporadic AD
Date: [208]
Request ID: T1417
Aim 1: Integrate novel CSF biomarkers into the timecourse of established AD features
Aim 2: Compare CSF biomarkers of Dominantly Inherited and Sporadic AD
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Investigator: Piotr Lewczuk
Project Title: Correlation of the Aβ PET uptake and the CSF Aβ42/40 ratio
Date: [208]
Request ID: T1416 Lewczuk
Aim 1: To determine if the CSF Aβ42/40 concentration ratio correlates better with the PIB-PET data than the Aβ1-42 concentration alone.
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Investigator: William G. Fairbrother
Project Title: Analysis of Defective pre-mRNA Splicing of Disease-causing PSEN1 Genetic Variants in Biological Samples from Alzheimer’s Disease Patients
Date: [208]
Request ID: T1414 Fairbrother
Aim 1: Validate results obtained using a high-throughput splicing assay with respect to causal PSEN1 mutations in biological samples, such as postmortem brain samples and/or blood, from Alzheimer’s disease patients.
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Investigator: Masaaki Matsuoka
Project Title: Calmodulin-like skin protein in Alzheimer’s disease
Date: [208]
Request ID: T1415
Aim 1: Calmodulin-like skin protein in the pathogenesis of Alzheimer’s disease
Aim 2: Diagnostic value of CLSP in Alzheimer’s disease
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Investigator: Alison Goate
Project Title: The role of phospholipase D3 in the lysosome
Date: [208]
Request ID: T1413
Aim 1: To determine whether PLD3 is detectable in lysosomes from human brain tissue
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Investigator: Jennifer Furman
Project Title: Tau Seeding Activity in Alzheimer’s Disease
Date: [208]
Request ID: T1412
Aim 1: Monitor seeding activity through AD disease progression
Aim 2: Test if seeding activity manifests early in tau progression
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Investigator: Randall J Bateman
Project Title: Optimization of ApoE Detection by LC/SRM-MS
Date: [208]
Request ID: T1411
Aim 1: Improve sample processing for absolute quantitation of ApoE isoforms in human cortex samples
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Investigator: Dr. Rademakers
Project Title: Progranulin: mutation and regulation in neurodegenerative disease
Date: [208]
Request ID: T1410
Aim 1: To identify genetic modifiers of symptom onset and/or presentation in GRN mutation carriers using a genome-wide association study (GWAS)
Aim 2: To identify genetic modifiers of symptom onset and/or presentation in GRN mutation carriers using an exome-sequencing approach
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Investigator: Vijay Sharma
Project Title: PET Tracers for Detection of AD
Date: [208]
Request ID: T1305-A
Aim 1: Assess senstivity of PET tracers to detect diffuse and fibrillar Ab-plaques in AD
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