The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Rawan Tarawneh/Carlos Cruchaga
Project Title: Endothelial Markers in AD
Date: [208]
Request ID: T2311
Aim 1: Examine diagnostic and prognostic value of endothelial injury markers across different stages of AD
Aim 2: Evaluate relationship of endothelial injury to fluid and imaging markers of AD pathology and neurodegeneration
Aim 3: Characterize the contribution of endothelial injury to cognitive decline in preclinical and early symptomatic AD
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Investigator: Zongtao Tom Lin
Project Title: Transforming Post-translational Arginylation into Targeted Tau Degradation Against Alzheimer’s Disease
Date: [208]
Request ID: T2312
Aim 1: Identify arginylation substrates in AD brains using activity-based arginylome profiling (ABAP).
Aim 2: Establish targeted tau degradation via ATE1 recruitment using FKBP-Halo system.
Aim 3: Develop ArgTACs for targeted tau degradation.
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Investigator: Dr. Gilbert Gallardo
Project Title: Evaluation of CSF levels of Glutamine in Knight ADRC cohort
Date: [208]
Request ID: t2313
Aim 1: We proposed to examine the glutamine levels in the CSF collected from AD humans with dementia.
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Investigator: Robert Bucelli
Project Title: Reference range for CSF neurofilament light
Date: [208]
Request ID: T2314
Aim 1: Generating a reference range for CSF NfL within the clinical NM Lab using our Simoa HD-X analyzer. Samples will be run on the Quanterix HD-X analyzer using the Simoa® NF-Light v2 Advantage Kit. Data from three datasets will be combined to develop a reference range.
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Investigator: Carlos Cruchaga
Project Title: Unbiased proteomic analyses and novel prediction models
Date: [208]
Request ID: T2315
Aim 1: To generate proteomic data using the Alamar platform
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Investigator: Takahisa Kanekiyo, David Holtzman, Alison Goate
Project Title: Determine apoE isoform-dependent changes in composition of apoE lipoprotein particles in human CSF
Date: [208]
Request ID: T2317
Aim 1: Purify apoE particles from human CSF samples using antibody-based pull-down assay.
Aim 2: Assess the apoE particle size distribution with human CSF samples.
Aim 3: Detect the apoE particles associated proteins and lipids by proteomics and lipidomics profiling.
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Investigator: Aaron Ring
Project Title: Decoding the Autoantibody ‘Reactome’ in Alzheimer’s Disease
Date: [208]
Request ID: T2316
Aim 1: Conduct an autoantibody-wide association study of Alzheimer’s Disease patients and matched controls to identify autoantibody responses that modify Alzheimer’s Disease risk and severity.
Aim 2: Evaluate the function and impact of Alzheimer’s Disease risk- or severity-modifying autoantibodies
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Investigator: Carlos Cruchaga
Project Title: CSF and plasma metabolomics characterization of AD and ADRD
Date: [208]
Request ID: T2318
Aim 1: Identification of metabolomics signatures and new prediction models for AD
Aim 2: Identify potential causal and druggable metabolites by using metabolomics-QTL and Mendelian randomization, colocalization, and PWAS approaches
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Investigator: Carlos Cruchaga
Project Title: Large Scale plasma proteomics of Alzheimer’s disease to identify novel biomarkers and causal targets
Date: [208]
Request ID: T2319
Aim 1: Identify plasma proteomic signatures and new prediction models for AD
Aim 2: Identify potential causal and druggable proteins by using pQTL and Mendelian randomization, colocalization, and PWAS approaches
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Investigator: Khairul Ansari
Project Title: Evaluation of the binding of hyperphosphorylayted Tau to normal tau as a biomarker for Alzheimer’s disease pathology and related Tauopathies in the Knight ADRC cohort
Date: [208]
Request ID: T2321
Aim 1: We now propose to run a small set of well-characterized samples from the Knight ADRC (n=40) described in the Cohort Selection Section to replicate the results of the pilot study
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