The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Marco Colonna
Project Title: MENINGEAL B CELLS IN AGING AND ALZHEIMER�S DISEASE
Date: December 21, 2021 at 5:02 pm
Request ID: T2010
Aim 1: TEST THE HYPOTHESIS THAT MENINGEAL B CELLS ORIGINATE FROM THE CALVARIAL BONE MARROW.
Aim 2: TO TEST THE HYPOTHESIS THAT THE DURA MENINGES B CELLS CLONALLY EXPAND DURING AGING AND BECOME AUTOREACTIVE ABC.
Aim 3: PROFILING THE MOLECULAR LANDSCAPE OF HUMAN DURA BY SINGLE-NUCLEI RNASEQ.
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Investigator: Harari, Cruchaga and Karch
Project Title: A molecular and cellular atlas of Alzheimer�s Disease and Neuropath-free brains
Date: December 21, 2021 at 5:02 pm
Request ID: T2009
Aim 1: To identify glial- and neuronal-specific events that lead to AD by generating single-nuclei data for AD and neuropath-free brains
Aim 2: To perform cell-type specific differential expression analyses
Aim 3: To identify the cell-type gene co-expression and co-regulated networks disrupted by AD
Aim 4: To identify cell-type expression quantitative traits locus (Ct-eQTL) by integrating single-nuclei data with GWAS and whole genome/exome sequencing
Investigator: Janardan P. Pandey
Project Title: Immunoglobulin GM Allotypes in Alzheimer’s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T2124
Aim 1: Determine if GM allotypes are risk factors for Alzheimer’s disease in African Americans
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Investigator: Judith Steen
Project Title: Comparison of P301S and P301L mouse models with Human subjects
Date: December 21, 2021 at 5:02 pm
Request ID: T2123
Aim 1: Profile P301S human patient tissue with FLEXITau
Aim 2: Profile P301S human patient tissue with global proteomics
Aim 3: Compare the human and mouse model Tau PTM profiles
Aim 4: Compare global proteomics data from human and mouse models with the P301S mutation
Investigator: Matthew Pase
Project Title: Comparing plasma neuroinflammatory markers between 16 fasting and 16 non-fasting patient samples
Date: December 21, 2021 at 5:02 pm
Request ID: T2117
Aim 1: To compare plasma neuroinflammatory markers between fasting and non-fasting patient samples. We will measure levels of YKL-40, GFAP, and sCD14 in fasting and non-fasting samples obtained from 8 healthy controls and 8 dementia patients (16 participants, 32 samples total).
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Investigator: Ynagyang Song
Project Title: Associatinos between life-span cognitive reserve and subtypes of Neuropsychological performance, Structural Brain Changes
Date: December 21, 2021 at 5:02 pm
Request ID: T2119
Aim 1: aim to examine whether life-span cognitive conserve is associated with subtypes of cognitive trajectories and brain structure
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Investigator: P. De Jager, D. Bennett
Project Title: AMP AD diverse brain profiling project
Date: December 21, 2021 at 5:02 pm
Request ID: T2118
Aim 1: Generate bulk RNAseq profile from BA9, anterior caudate, and superior temporal gyrus
Aim 2: Generate Whole Genome Sequence Data frpm BA9
Aim 3: Generate TMT-based shotgun proteomic profile of BA9
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Investigator: Konrad Talbot
Project Title: Treating Alzheimer�s Disease by Reducing Brain Insulin Resistance with Incretin Receptor Agonists
Date: December 21, 2021 at 5:02 pm
Request ID: T2116
Aim 1: To quantify insulin responsiveness of the hippocampal formation (HF) from normal, MCI, and AD cases, test signaling responses of the HF from those cases to 1 and 10 nM insulin using an ex vivo insulin stimulation method validated for postmortem cases with PMIs less than 14 hours.
Aim 2: To test the ability of antidiabetics known as incretin receptor agonists (IRAs) to reduce known insulin resistance in the HF from MCI and AD cases by comparing the insulin responsiveness of the HF from such cases with or without IRA pretreatment using the ex vivo insulin stimulation method.
Aim 3: To test biochemical changes induced by IRAs that may account for their ability to reduce insulin resistance in the HF from MCI and AD cases based on preliminary data from ex vivo insulin stimulation experiments.
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Investigator: Erin H. Norris
Project Title: Investigation of a prothrombotic state in AD patient plasma: Monitoring plasma contact system activation in AD pathophysiology
Date: December 21, 2021 at 5:02 pm
Request ID: T1306-B
Aim 1: Analysis of plasma contact system activation from large cohort of age- and sex-matched individuals diagnosed as non-demented (ND) or AD.
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Investigator: Wesley Horton
Project Title: Inflammatory Markers for Early Detection and Subtyping of Neurodegenerative and Mood Disorders Tissue Request to Washington University ADRC
Date: December 21, 2021 at 5:02 pm
Request ID: T2109
Aim 1: Determine the relationship of inflammatory markers in CSF and Plasma to clinical observations [Biomarker Signature Development]
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