The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Pau Pastor
Project Title: Clinical and neuroimaging characterization of Alzheimer TREM2 p.R47H carriers
Date: [153]
Request ID: D1317
Aim 1: To compare clinical featuresof Alzheimer TREM2 p.R47H carriers vs noncarriers and ctrl
Aim 2: To compare neuroimaging features (MRI) by VBM of Alzheimer TREM2 p.R47H vs noncarriers and controls
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Investigator: Beau Ances
Project Title: Comparing Functional Connectivity and CSF in Autosomal Dominant and Late Onset AD
Date: [153]
Request ID: D1316
Aim 1: Characterize relationship between CSF & functional connectivity in autosomal dominant AD (ADAD).
Aim 2: Compare relationship between CSF and FC for ADAD and late onset AD (LOAD).
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Investigator: Anne Fagan and Maartje Kester
Project Title: APOE genotype and CSF biomarkers in predictive models for cognitive decline and Alzheimer’s disease
Date: [153]
Request ID: D1315
Aim 1: to look at the effect of APOE genotype on the diagnostic and prognostic ability of CSF biomarkers.
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Investigator: Yaakov Stern
Project Title: A new prediction algorithm for mortality and nursing home admission.
Date: [153]
Request ID: D1314
Aim 1: To validate a prediction algorithm.
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Investigator: Grant – John C. Morris, MD. This project – Jennifer Phillips
Project Title: Factors Influencing Assent for Brain Donation
Date: [153]
Request ID: D1313
Aim 1: To examine data from the past ten years and determine the time that participants are most likely to
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Investigator: JC Morris
Project Title: PIB negative but cognitively impaired
Date: [153]
Request ID: D1312
Aim 1: Evaluate possible reasons for the discordance between clinical status and imaging biomarker status
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Investigator: John c Morris
Project Title: Noncognitive markers of preclinical AD
Date: [153]
Request ID: D1311
Aim 1: Correlate Hgb A1c, body mass index, and related markers (eg, body wieght) with biomarkers in preclin
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Investigator: Terrance Kummer
Project Title: Axon injury in intracerebral hemorrhage
Date: [153]
Request ID: D1310
Aim 1: Determine the extent of local and global acute axonal injury after ICH using diffusion tensor imagin
Aim 2: Examine the sub-acute evolution of local and global axonal injury following ICH
Aim 3: Examine the chronic evolution of local and global axonal injury after ICH, and determine which is be
Aim 4: Compare radiological biomarkers of axonal injury resulting from ICH with biochemical biomarkers obta
Investigator: Kathleen Vernon
Project Title: Lateralization of Atrophy and Behavioral Disturbance in AD
Date: [153]
Request ID: D1309
Aim 1: Determine if lateralized brain atrophy in mild AD is related to types of behavioral disturbance.
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Investigator: B. Joy Snider
Project Title: Role of Cerebrospinal fluid studies in Diagnosis and Treatment of Dementing Disorders at MDC
Date: [153]
Request ID: D1308
Aim 1: Characterize patients selected for CSF analysis as part of dementia evaluation
Aim 2: Determine if CSF results, specifically disease-related biomarkers, change diagnosis or treatment
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