Search Existing Data Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


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Investigator: Behrens, Maria

Project Title: Follow-up of MAP patients with and without anticholinesterase inhibitors.

Date: December 21, 2021 at 5:18 pm

Request ID: D0334

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Investigator: Roe, Catherine

Project Title: Memory Complaints in Individuals without Cognitive Impairment

Date: December 21, 2021 at 5:18 pm

Request ID: D0812

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Investigator: Gina D’Angelo

Project Title: Missing data approaches for partial correlations of regional volumetric data

Date: December 21, 2021 at 5:18 pm

Request ID: D1025

Aim 1: Extend the partial correlation coefficient in the presence of missing data using the EM algorithm

Aim 2: Use (1) to study relationships among regional brain measures while adjusting for other variables

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Investigator: B. Joy Snider

Project Title: Genotype-Phenotype Correlations in Dominantly Inherited Dementing Disorders

Date: December 21, 2021 at 5:18 pm

Request ID: D1026

Aim 1: Look for correlations between clinical phenotype with mutation in those with known mutation

Aim 2: look for correlation between rate of progression and mutation

Aim 3: preliminary analysis of biomarkers in known mutations

Aim 4: preliminary analysis of PET_PIB in known mutations


Investigator: David B. Carr, MD

Project Title: Functional Impairment in PIB+ Healthy Older Adults

Date: December 21, 2021 at 5:18 pm

Request ID: D1101

Aim 1: Is there a lower prevalence of active drivers in PIB+ CDR=0 participants?

Aim 2: Of the active driver pool, are PIB+ CDR=0 drivers believed to be at more risk than PIB-?

Aim 3: Is functional impairment (FAQ) more prevalent in PIB+ CDR=0 participants?

Aim 4: Do PIB+ CDR=0 participants have a higher rate of functional decline over time?


Investigator: Dr. Denise Head

Project Title: Effects of the BDNF polymorphism and exercise on brain structure, AD biomarkers and cognition.

Date: December 21, 2021 at 5:18 pm

Request ID: D1102

Aim 1: examine the effects of the BDNF polymorphism on brain, cognition, and AD biomarkers

Aim 2: examine interactions between the BDNF polymorphism and exercise

Aim 3: examine interactions between the BDNF polymorphism and age

Aim 4: examine interactions between the APOE and BDNF polymorphisms


Investigator: Luigi Maccotta

Project Title: Functional Connectivity in Epilepsy

Date: December 21, 2021 at 5:18 pm

Request ID: D1103

Aim 1: To characterize changes in local and long-range functional connections in temporal lobe epilepsy

Aim 2: To characterize connectivity changes in TLE patients with grossly normal brain anatomy

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Investigator: Dr. John Morris

Project Title: Age of Onset Disparities among first degree relatives

Date: December 21, 2021 at 5:18 pm

Request ID: D1104

Aim 1: To determine the causes for AOO disparities among first degree relatives

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Investigator: Catherine M. Roe

Project Title: IMPROVING PRESYMPTOMATIC DETECTION OF IMPENDING ALZHEIMER’S DISEASE

Date: December 21, 2021 at 5:18 pm

Request ID: D1105

Aim 1: To examine how cognitive and brain reserve factors combine with AD biomarkers

Aim 2: To build biomarker models that yield individual risk profiles predicting the time of AD onset.

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Investigator: Jonathan Day

Project Title: Assessment of Current Alzheimer’s Disease Therapies Using Neuroimaging and CSF Biomarkers: A Pilot S

Date: December 21, 2021 at 5:18 pm

Request ID: D1106

Aim 1: Assess the effectiveness of AD therapies from a neuroimaging and biomarker standpoints

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