Search Existing Data Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


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Investigator: Steven G. Younkin

Project Title: Association of Sickle Cell Trait With Alzheimer’s Disease

Date: December 21, 2021 at 5:18 pm

Request ID: D1415

Aim 1: Determine if sickle cell trait (SCT) is associated with Alzheimer’s Disease

Aim 2: Determine if there is a significant interaction between age and the association of SCT with LOAD

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Investigator: B. Joy Snider

Project Title: Role of Cerebrospinal fluid studies in Diagnosis and Treatment of Dementing Disorders at MDC

Date: December 21, 2021 at 5:18 pm

Request ID: D1308

Aim 1: Characterize patients selected for CSF analysis as part of dementia evaluation

Aim 2: Determine if CSF results, specifically disease-related biomarkers, change diagnosis or treatment

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Investigator: Swerdlow

Project Title: A predictive prognostic model for Alzheimer’s disease

Date: December 21, 2021 at 5:18 pm

Request ID: D1307

Aim 1: Evaluate the reproducibility of the Bayesian Belief Network (BBN) in autopsy-confirmed AD

Aim 2: : Evaluate convergent validity of the BBN by comparing the model diagnoses to expert diagnoses

Aim 3: Extend the neurocognitive-based BBN to include KADRC biomarker data

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Investigator: Adam Ingber

Project Title: Reserve variables and the relationship between AD biomarkers and non-cognitive outcomes

Date: December 21, 2021 at 5:18 pm

Request ID: D1306

Aim 1: To examine how cognitive and brain reserve measures mediate associations between AD biomarkers and n

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Investigator: Cruchaga Carlos

Project Title: Identification of rare variants implicated on Alzheimer’s Disease

Date: December 21, 2021 at 5:18 pm

Request ID: D1305

Aim 1: To identify and better understand the neuropathological findings for the PSEN1, p.E318G carriers

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Investigator: John C. Morris

Project Title: Investigating COMT and Intraindividual Variability

Date: December 21, 2021 at 5:18 pm

Request ID: D1304

Aim 1: Determine whether COMT is independently related to intraindividual variability in reaction time.

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Investigator: Beau Ances MD, PhD, MSc

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Date: December 21, 2021 at 5:18 pm

Request ID: D1303

Aim 1: To explore novel complex measures using multi-scale entropy in rs-fcMRI data from an HASD cohort.

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Investigator: Yuan-Han,Yang

Project Title: ACE gene in AD with hypertension among African American and Caucasian American

Date: December 21, 2021 at 5:18 pm

Request ID: D1302

Aim 1: Examine the association of ACE gene in LOAD with / without hypertension in CA and AA

Aim 2: Examine the clinical course of LOAD in relation to their ACE indel polymorphism in CA and AA.

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Investigator: Xiong Yunyun

Project Title: The association between PiB retention and cognitive decline

Date: December 21, 2021 at 5:18 pm

Request ID: D1301

Aim 1: a meta analysis investigating the prognostic value of baseline PiB status on the development of AD

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Investigator: Daniel Marcus

Project Title: Development of a tool for quantitative analysis of MRI and PET in clinical dementia

Date: December 21, 2021 at 5:18 pm

Request ID: D1223

Aim 1: NA (this is not a research project)

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