The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Steven G. Younkin
Project Title: Association of Sickle Cell Trait With Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1415
Aim 1: Determine if sickle cell trait (SCT) is associated with Alzheimer’s Disease
Aim 2: Determine if there is a significant interaction between age and the association of SCT with LOAD
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Investigator: B. Joy Snider
Project Title: Role of Cerebrospinal fluid studies in Diagnosis and Treatment of Dementing Disorders at MDC
Date: December 21, 2021 at 5:18 pm
Request ID: D1308
Aim 1: Characterize patients selected for CSF analysis as part of dementia evaluation
Aim 2: Determine if CSF results, specifically disease-related biomarkers, change diagnosis or treatment
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Investigator: Swerdlow
Project Title: A predictive prognostic model for Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1307
Aim 1: Evaluate the reproducibility of the Bayesian Belief Network (BBN) in autopsy-confirmed AD
Aim 2: : Evaluate convergent validity of the BBN by comparing the model diagnoses to expert diagnoses
Aim 3: Extend the neurocognitive-based BBN to include KADRC biomarker data
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Investigator: Adam Ingber
Project Title: Reserve variables and the relationship between AD biomarkers and non-cognitive outcomes
Date: December 21, 2021 at 5:18 pm
Request ID: D1306
Aim 1: To examine how cognitive and brain reserve measures mediate associations between AD biomarkers and n
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Investigator: Cruchaga Carlos
Project Title: Identification of rare variants implicated on Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1305
Aim 1: To identify and better understand the neuropathological findings for the PSEN1, p.E318G carriers
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Investigator: John C. Morris
Project Title: Investigating COMT and Intraindividual Variability
Date: December 21, 2021 at 5:18 pm
Request ID: D1304
Aim 1: Determine whether COMT is independently related to intraindividual variability in reaction time.
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Investigator: Beau Ances MD, PhD, MSc
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Date: December 21, 2021 at 5:18 pm
Request ID: D1303
Aim 1: To explore novel complex measures using multi-scale entropy in rs-fcMRI data from an HASD cohort.
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Investigator: Yuan-Han,Yang
Project Title: ACE gene in AD with hypertension among African American and Caucasian American
Date: December 21, 2021 at 5:18 pm
Request ID: D1302
Aim 1: Examine the association of ACE gene in LOAD with / without hypertension in CA and AA
Aim 2: Examine the clinical course of LOAD in relation to their ACE indel polymorphism in CA and AA.
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Investigator: Xiong Yunyun
Project Title: The association between PiB retention and cognitive decline
Date: December 21, 2021 at 5:18 pm
Request ID: D1301
Aim 1: a meta analysis investigating the prognostic value of baseline PiB status on the development of AD
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Investigator: Daniel Marcus
Project Title: Development of a tool for quantitative analysis of MRI and PET in clinical dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1223
Aim 1: NA (this is not a research project)
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