The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Dr. John Morris
Project Title: Age of Onset Disparities among first degree relatives
Date: December 21, 2021 at 5:18 pm
Request ID: D1104
Aim 1: To determine the causes for AOO disparities among first degree relatives
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Investigator: Catherine M. Roe
Project Title: Use of Alzheimer’s Disease Biomarkers to Predict Longevity and Disability
Date: December 21, 2021 at 5:18 pm
Request ID: D1215
Aim 1: To examine whether AD biomarker levels in cognitively normal persons predict longevity and disabilit
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Investigator: Rachel Chasse
Project Title: Enhancing Normative Cognitive Data with Information from Biomarkers and Neuroimaging.
Date: December 21, 2021 at 5:18 pm
Request ID: D1214
Aim 1: Assemble a normative cognitive database informed by biomarker evidence of AD neuropathology.
Aim 2: Determine if this ‘super’ normative database will improve early detection of cognitive decline.
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Investigator: Alison Goate
Project Title: Clinicopathological correlations of MAPT A152T mutation carriers
Date: December 21, 2021 at 5:18 pm
Request ID: D1213
Aim 1: Characterize clinical phenotype of MAPT A152T mutation carriers
Aim 2: Characterize pathological phenotype of MAPT A152T mutation carriers
Aim 3: Characterize molecular phenotype of MAPT A152T mutation carriers
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Investigator: Alison Goate/Oscar Harari
Project Title: Identification of genetic factors associated with rate of progression
Date: December 21, 2021 at 5:18 pm
Request ID: D1212
Aim 1: To replicate the association of rs1868402 with rate of progression
Aim 2: To analyze whether other genetic factors associated with CSF ptau181 levels
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Investigator: Brooke Sadler
Project Title: The Evolutionary Role of Nicotinic Receptors in Memory and Cognitive Performance
Date: December 21, 2021 at 5:18 pm
Request ID: D1210
Aim 1: Examine association between genotypes in nicotinic receptors with phenotypes related to cognition
Aim 2: Determine if these genotypes are at different frequencies among AD vs non AD participants
Aim 3: Relate these frequency differences back to historical selective pressures on increased cognition
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Investigator: Phillip Hsu
Project Title: Risk factors associated with Headache due to Lumbar Puncture
Date: December 21, 2021 at 5:18 pm
Request ID: D1209
Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache
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Investigator: Zheyu Wang
Project Title: Biomarker Evaluation in the Absence of a Gold Standard
Date: December 21, 2021 at 5:18 pm
Request ID: D1208
Aim 1: Methodology development on evaluating biomarkers in the absence of a gold standard
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Investigator: Chengjie Xiong
Project Title: Two Preclinical Latent Scores to Predict Occurrence of DAT
Date: December 21, 2021 at 5:18 pm
Request ID: D1206
Aim 1: Assess the antecedent longitudinal changes and their predictive power of DAT for individual items of
Aim 2: Aim 2. Evaluate the use of IRT
Aim 3: Develop clinically meaningful score reports
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Investigator: Catherine M. Roe
Project Title: Alzheimer’s disease biomarkers and cancer
Date: December 21, 2021 at 5:18 pm
Request ID: D1207
Aim 1: To examine whether Alzheimer’s disease biomarkers are associated with cancer
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