The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Alison Goate/Oscar Harari
Project Title: Identification of genetic factors associated with rate of progression
Date: December 21, 2021 at 5:18 pm
Request ID: D1212
Aim 1: To replicate the association of rs1868402 with rate of progression
Aim 2: To analyze whether other genetic factors associated with CSF ptau181 levels
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Investigator: Charles DeCarli
Project Title: NACC MRI Genotype Association Studies
Date: December 21, 2021 at 5:18 pm
Request ID: D1211
Aim 1: Acquire MRI data related to TCV and Hippocampal estimates from NACC participating sites
Aim 2: Match MRI data with ADGC acquired genotype data on NACC enrolled subjects
Aim 3: Examine candidate gene associations from prior publications
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Investigator: John C Morris
Project Title: Multimodal biomarker prediction
Date: December 21, 2021 at 5:18 pm
Request ID: D1109
Aim 1: Evaluate biomarker combinations that predict clinical outcomes in cognitively normal and DAT persons
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Investigator: Alison Goate
Project Title: Genetics of CSF endophenotypes for AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1110
Aim 1: To identify genes that influence the CSF levels of AD biomarkers
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Investigator: Alison Goate
Project Title: TOMM40 and neuroimaging phenotypes
Date: December 21, 2021 at 5:18 pm
Request ID: D1111
Aim 1: Test hypothesis from Mark Sager regarding relationship between TOMM40 genotypes and neuroimaging phe
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Investigator: Alison Goate
Project Title: Clinicopathological correlations of MAPT A152T mutation carriers
Date: December 21, 2021 at 5:18 pm
Request ID: D1213
Aim 1: Characterize clinical phenotype of MAPT A152T mutation carriers
Aim 2: Characterize pathological phenotype of MAPT A152T mutation carriers
Aim 3: Characterize molecular phenotype of MAPT A152T mutation carriers
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Investigator: Chengjie Xiong
Project Title: Two Preclinical Latent Scores to Predict Occurrence of DAT
Date: December 21, 2021 at 5:18 pm
Request ID: D1206
Aim 1: Assess the antecedent longitudinal changes and their predictive power of DAT for individual items of
Aim 2: Aim 2. Evaluate the use of IRT
Aim 3: Develop clinically meaningful score reports
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Investigator: Catherine M. Roe
Project Title: Alzheimer’s disease biomarkers and cancer
Date: December 21, 2021 at 5:18 pm
Request ID: D1207
Aim 1: To examine whether Alzheimer’s disease biomarkers are associated with cancer
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Investigator: Zheyu Wang
Project Title: Biomarker Evaluation in the Absence of a Gold Standard
Date: December 21, 2021 at 5:18 pm
Request ID: D1208
Aim 1: Methodology development on evaluating biomarkers in the absence of a gold standard
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Investigator: Phillip Hsu
Project Title: Risk factors associated with Headache due to Lumbar Puncture
Date: December 21, 2021 at 5:18 pm
Request ID: D1209
Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache
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