The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Sebastien Ourselin
Project Title: Validation of attenuation correction synthesis for PET-MR scanners
Date: December 21, 2021 at 5:18 pm
Request ID: D1519
Aim 1: Validate a novel method of attenuation correction for PET-MR data by creating “pseudo-CT” images that are created based on information provided from a template library of co-registered MR and CT pairs.
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Investigator: Beau Ances
Project Title: The Influence of Traumatic Brain Injury on Anatomical Morphometry in Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1518
Aim 1: Are hippocampal volumes different cross-sectionally between AD patients with and without the presence of a TBI and LOC?
Aim 2: Is the degenerative component for AD patients with a TBI and LOC
Aim 3: Longitudinally, is the AD progression more drastic in patients who experienced a TBI with LOC compared to AD patients without a TBI
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Investigator: Lenise Cummings-Vaughn
Project Title: Exploring AD Biomarker Disparities Between African Americans and European Americans
Date: December 21, 2021 at 5:18 pm
Request ID: D1517
Aim 1: Determine whether Alzhemer Disease (AD) biomarker abnormalities vary as a function of race or ethnicity
Aim 2: Determine if African Americans with preclinical AD have a higher frequency of cerebrovascular lesions.
Aim 3: Determine if African Americans with preclinical AD have higher frequency of hypovitaminosis D.
Aim 4: Determine if African Americans with preclinical AD have a higher frequency of chronic inflammation.
Investigator: Kirchhoff
Project Title: An Investigation of the Relationships Between Brain Structure and Attentional Control
Date: December 21, 2021 at 5:18 pm
Request ID: D1516
Aim 1: To identify brain regions that support successful attentional control processes by examining the relationships between brain structure and performance on attentional control tasks.
Aim 2: To investigate the brain structural changes that lead to attentional control impairments in Alzheimer�s Disease.
Aim 3: To examine whether brain structure at least partially mediates the relationships between AD risk and attentional control.
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Investigator: Angela Curl
Project Title: Psychometric Testing of the CARS Instrument
Date: December 21, 2021 at 5:18 pm
Request ID: –
Aim 1: To test the psychometric reliability of the newly developed CARS Instrument
Aim 2: To test the psychometric validity of the newly developed CARS Instrument
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Investigator: Zehra Onen
Project Title: Optimal Population Screening Policies for Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1514
Aim 1: To compute optimal population screening policies for Alzheimer�s Disease (AD) using Markov Decision Process (MDP) and Partially Observable MDP models.
Aim 2: To compute annual transition probabilities within AD free and preclinical stage individuals
Aim 3: To build mathematical models for biomarkers’ progression focusing on normal individuals and individuals in preclinical stages of Alzheimer’s Disease
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Investigator: Samantha Allison
Project Title: Relationship between proton pump inhibitors and risk of dementia, cognition, brain structure, and Alzheimer disease biomarkers
Date: December 21, 2021 at 5:18 pm
Request ID: D1701
Aim 1: Examine the relationship between proton pump inhibitors and both risk of dementia and longitudinal change in cognition.
Aim 2: Examine the relationship between proton pump inhibitors and biological markers of Alzheimer disease (e.g., regional based brain volumes obtained via structural MRI, amyloid PET, and CSF biomarkers).
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Investigator: Sergey Shcherbinin
Project Title: Potential usage of PET-based perfusion measurements as candidates neurodegeneration biomarkers
Date: December 21, 2021 at 5:18 pm
Request ID: D1702
Aim 1: Analyze dynamic PET images obtained using different radiotracers
Aim 2: Optimize time window to measure perfusion using PET tracers
Aim 3: Perform cross-sectional and longitudinal comparison between perfusion measures and other biomarkers/scores
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Investigator: Arnaud Charil
Project Title: Potential usage of diffusion basis spectrum imaging (DBSI) to assess white matter inflammation in Alzheimer�s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1703
Aim 1: Generate a normative profile (across brain regions/tracts and subjects) of DBSI parameters, suitable for expressing (defining) �abnormal� levels of these parameters
Aim 2: Explore the profile of abnormalities in the different DBSI parameters in more advanced NIA-AA stage individuals
Aim 3: Refine potential analysis strategies for application to clinical trials
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Investigator: Jee-young Han
Project Title: Clinical outcomes and its predictors in CDR 0.5, uncertain dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1704
Aim 1: To define and differentiate clinical characteristics of CDR 0.5, uncertain dementia
Aim 2: To demonstrate the clinical outcomes of CDR 0.5, uncertain dementia
Aim 3: To determine predictors of progression of CDR 0.5, uncertain dementia to AD
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