The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Karin Meeker
Project Title: Alzheimer disease heterogeneity profiles in ethno-racial minorities
Date: [153]
Request ID: D2204
Aim 1: Determine AD brain volume heterogeneity profiles of neuroimaging markers (i.e., magnetic resonance imaging [MRI], resting-state functional connectivity [RS-FC]), cognition, and AD biomarkers (i.e., plasma amyloid and tau).
Aim 2: Assess group differences in heterogeneity profiles between Blacks and Non-Hispanic Whites.
Aim 3: Determine whether social determinants of health (SDOH; e.g., ADI) mediate group differences in heterogeneity profiles.
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Investigator: Brian Gordon
Project Title: Comparing biomarkers between Down Syndrome, Autosomal Dominant, and Late onset Alzheimer Disease
Date: [153]
Request ID: D2205
Aim 1: How do measures of tau pathology measured using PET compare among DS, ADAD, and LOAD?
Aim 2: Does the spread of tau pathology over time differ between cohorts?
Aim 3: How do the degree and spatial patterns of neurodegeneration compare between DS, ADAD, and LOAD?
Aim 4: How do biofluid profiles compare between DS, ADAD, and LOAD? We will expand upon our prior publication
Investigator: Timothy J. Hohman
Project Title: Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium
Date: [153]
Request ID: D2206
Aim 1: Procure, collate, and curate endophenotype data from ADSP cohort studies
Aim 2: Harmonize data from ADSP cohort studies leveraging advanced statistical approaches
Aim 3: Disseminate harmonization protocols and harmonized phenotypes to the research community
Aim 4: Educate the research community on available harmonized resources and best practices
Investigator: Ron Anafi
Project Title: Circadian Organization and Disorder in Alzheimer’s Disease
Date: [153]
Request ID: D2207
Aim 1: Examine circadian phase in post-mortem human brain tissue in AD and control using transcriptional analysis with CYCLOPS
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Investigator: John Morris
Project Title: Predictors and Outcomes of Clinical Dementia Rating Reversion.
Date: [153]
Request ID: D2208
Aim 1: To understand the clinical significance of individuals who revert between cognitive normality and meeting the clinical diagnostic criteria for dementia on the Clinical Dementia Rating (CDR) score, coined “reversion.”
Aim 2: To examine if reversion is related to cognition, genetics, fluid biomarkers, and neuroimaging markers.
Aim 3: To examine if instances of reversion are a predictor of future stable CDR >0 and a clinical diagnosis of Alzheimer’s Disease (AD).
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Investigator: Janardan P. Pandey
Project Title: Immunoglobulin GM Allotypes in Alzheimer’s Disease
Date: [153]
Request ID: D2209
Aim 1: Determine if GM allotypes are risk factors for Alzheimer’s disease in African Americans
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Investigator: Catherine Kaczorowski
Project Title: Systems Genetics Analysis of Alzheimer’s Disease-Related Sleep Loss and the Transition to Dementia
Date: [153]
Request ID: D2210
Aim 1: Identify genes and molecular networks associated with sleep loss in new mouse models of human AD.
Aim 2: Translate genes and molecular networks underlying variation in sleep loss in human AD cohorts.
Aim 3: Validate genetic factors associated with AD-related sleep dysfunction and determine their impact on memory in powerful AD models.
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Investigator: Colin Masters
Project Title: Prof. Schindler Neurology Paper Validation using ADOPIC
Date: [153]
Request ID: D2211
Aim 1: Validate the time at which Amyloid begins to accumulate in the brain using Prof Schindler’s method as described in her Nerorology paper using CapAIBL generated Centilid values.
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Investigator: Tony Wyss-Coray
Project Title: ADRC Collaboration: Wyss-Coray Lab and Cruchaga Lab
Date: [153]
Request ID: D2212
Aim 1: Validation of Organ-Specific Aging Signatures in Neurodegenerative Disease
Aim 2: Assessing CSF:Plasma Protein Ratios in Aging and Neurodegenerative Disease
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Investigator: Tao Sun
Project Title: Tau-PET change along with Alzheimer’s disease: from a topology perspective
Date: [153]
Request ID: D2213
Aim 1: Investigate the longitudinal change of tau deposition from network perspective
Aim 2: Identify related biomarkers for early AD detection in prodromal stage
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