The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Dr. John C. Morris
Project Title: The rule of sleep, personality, and aging: How these interactions affect cognition
Date: December 21, 2021 at 5:18 pm
Request ID: D1119
Aim 1: When comparing CDR 0 to CDR 0.5, 0.5’s would have higher levels of neuroticism & sleep difficulties
Aim 2: Within CDR0, those with high neuroticism & sleep difficulties will have lower cognition performance
Aim 3: Of those who progress to higher CDR, more of the high neuroticism and sleep problems group
Aim 4: High neuroticism group show more awakening and activity on actigraphs
Investigator: Danny JJ Wang
Project Title: Complexity and synchronicty of resting state fMRI time-series in Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1128
Aim 1: To quantify the complexity of resting fMRI using ApEn in AD, MCI and NC subjects
Aim 2: To quantify the asynchrony of resting fMRI using C-ApEn and compare with cross-correlation
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Investigator: Brian Carpenter
Project Title: Ability of Collateral Informants to Describe Patient Functioning
Date: December 21, 2021 at 5:18 pm
Request ID: D1127
Aim 1: Determine the base rate of collaterals who are rated as having questionable or poor accuracy
Aim 2: Determine the base rate of reasons for collateral inaccuracy
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Investigator: David Holtzman
Project Title: Clinicopathologic Characterization of Late-Onset Autosomal Dominant AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1126
Aim 1: Identify clinical charactersitics of family LO6 who harbor PSEN1 A79V mutations
Aim 2: Examine CSF and Imaging biomarkers in individuals from family LO6
Aim 3: Compare clinical and biomarker data between LO6 and early-onset kindreds with PSEN1 A79V mut
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Investigator: Carlos Cruchaga/Alison Goate
Project Title: To test whether the poly-T polymorphism (rs10524523) is associated with change in gray matter volume
Date: December 21, 2021 at 5:18 pm
Request ID: D1125
Aim 1: Try to replicate the Dr. Sager neuroimaging findings in a larger series
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Investigator: David Holtzman/Alison Goate
Project Title: To identify genetic variation that influences VILIP1 levels in cerebrospinal fluid
Date: December 21, 2021 at 5:18 pm
Request ID: D1124
Aim 1: To identify polymorphisms that explain variability in CSF VILIP1 levels.
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Investigator: Denise Head
Project Title: The Relationship Between Stress and Biomarkers of Alzheimer’s Diseases
Date: December 21, 2021 at 5:18 pm
Request ID: D1123
Aim 1: To determine the relationship between stress exposure and AD biomarkers
Aim 2: To investigate whether stress exacerbates the effects of age on AD biomarkers
Aim 3: To examine whether stress exacerbates the effects of APOE e4 and/or met-BDNF allele on AD biomarkers
Aim 4: To examine the interaction effect between stress and exercise on AD biomarkers
Investigator: Joanne Conover
Project Title: Ventricular Expansion and Leakiness in Normal Aging
Date: December 21, 2021 at 5:18 pm
Request ID: D1122
Aim 1: Regional Trends in Expansion and Hyperintensities Using FLAIR-MRI
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Investigator: Robyn A Honea
Project Title: The Role of Genetic Variation in Alzheimer’s Disease Neurodegeneration
Date: December 21, 2021 at 5:18 pm
Request ID: D1121
Aim 1: Assess the relationship of selected candidate genes with MRI phenotypes and cognitive markers of AD
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Investigator: Jessica Nichols (student in Friedman Program)
Project Title: Effect of Type 2 Diabetes Mellitus on Resting State Functional Connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1120
Aim 1: look at how T2DM affects resting state functional connectivity and if it is a risk factor for AD
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