The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Denise Head
Project Title: Cognitive profiles in the Adult Children Study
Date: December 21, 2021 at 5:18 pm
Request ID: D1325
Aim 1: Confirm the the latent factor structure of the psychometric battery for the Adult Children Study
Aim 2: Test potential differences in factor structure based on family history of AD
Aim 3: Test potential differences in factor structure based on APOE status
Aim 4: Test potential differences in factor structure based on age
Investigator: Catherine Roe
Project Title: Use of Alzheimer’s Disease Biomarkers to Predict UPDRS Symptoms
Date: December 21, 2021 at 5:18 pm
Request ID: D1324
Aim 1: To examine the extent to which AD biomarker levels in cognitively normal persons predict PD symptoms
Aim 2: to examine the extent to which AD biomarkers predict rate of change of parkinsonian symptoms in individuals with AD at baseline.
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Investigator: John C Morris
Project Title: Examine neuropathological correlates of subjective memory complaints
Date: December 21, 2021 at 5:18 pm
Request ID: D1323
Aim 1: . Describe the relationship between main neuropathological findings of Alzheimer’s disease (β-amyloi
Aim 2: Clarify the role of the accompanying neuropathological findings (white matter change, ischemia, infa
Aim 3: Determine what neuropathological finding is the best candidates to explain SMC.
Aim 4: Compare other clinical and biological variables (CDR-SB, ApoE,) between participants with or without
Investigator: John C Morris
Project Title: Crossed Alexia without Agraphia in Progressive Posterior Cortical Dysfunction caused by Alzheimer’s
Date: December 21, 2021 at 5:18 pm
Request ID: D1322
Aim 1: Report the first case of pathologically proven crossed alexia without agraphia in a posterior cortic
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Investigator: JC Morris
Project Title: Validation of the AD8
Date: December 21, 2021 at 5:18 pm
Request ID: D1321
Aim 1: Determine AD8 scores for all participants at baseline since Sept 2005 who later came to autopsy
Aim 2: Correlate AD8 positive and AD8 negative individuals with neuropathological diagnoses
Aim 3: Correlate AD8 scores with subjective memory complaints
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Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with AD progression rate
Date: December 21, 2021 at 5:18 pm
Request ID: D1320
Aim 1: Psychometric scores from the different test and contributed sites will be combined
Aim 2: A GWAS will be running using several psychometric test as endophentypes
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Investigator: CAMD consortium
Project Title: CAMD request for biomarker data
Date: December 21, 2021 at 5:18 pm
Request ID: D1319
Aim 1: FDA biomarker qualification
Aim 2: Alzheimer’s disease progression modeling
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Investigator: Stephanie Vos
Project Title: Prevalence of amyloid pathology in healthy and cognitively impaired individuals
Date: December 21, 2021 at 5:18 pm
Request ID: D1318
Aim 1: To characterize amyloid prevalence according to baselin cognitive scores (CDR, MMSE, delayed recall)
Aim 2: To characterize amyloid prevalence according to age, apoE genotype
Aim 3: To characterize amyloid prevalence according to future cognitive scores (CDR, MMSE, delayed recall)
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Investigator: Beau Ances
Project Title: Comparing Functional Connectivity and CSF in Autosomal Dominant and Late Onset AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1316
Aim 1: Characterize relationship between CSF & functional connectivity in autosomal dominant AD (ADAD).
Aim 2: Compare relationship between CSF and FC for ADAD and late onset AD (LOAD).
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Investigator: Anne Fagan and Maartje Kester
Project Title: APOE genotype and CSF biomarkers in predictive models for cognitive decline and Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1315
Aim 1: to look at the effect of APOE genotype on the diagnostic and prognostic ability of CSF biomarkers.
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