The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Isabelle Bos
Project Title: The relationship between dementia risk factors and AD biomarkers in preclinical AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1623
Aim 1: To investigate the prevalence of vascular risk factors in different groups of cognitively normal individuals, classified according to their biomarker profile.
Aim 2: To examine the influence of risk factors on cognitive decline.
Aim 3: To explore the interplay between risk factors in their association with AD biomarkers.
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Investigator: Jason Hassenstab
Project Title: Characterization of Cognitive Aging in a Robust Sample of Healthy Older Adults
Date: December 21, 2021 at 5:18 pm
Request ID: D1624
Aim 1: Detemine the contribution of normal aging on cognitive trajectories in biomarker positive cognitively normal adults compared to biomarker negative older adults.
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Investigator: Teodoro Bottiglieri
Project Title: Methionine and methylation cycle metabolites in dementia.
Date: December 21, 2021 at 5:18 pm
Request ID: D1625
Aim 1: To determine and compare metabolites related to methionine metabolism and methylation in plasma and CSF from a cohort of subjects who cognitively normal and with mild dementia of the Alzheimer�s type.
Aim 2: To determine the relationship between metabolites related to homocysteine metabolism and methylation with other biomarkers of Alzheimer�s disease (i.e.ApoE genotype, beta-amyloid 1-40 and 1-42, Tau and p-Tau) in plasma and CSF.
Aim 3: To determine if metabolites of the methionine cycle and methylation are correlated with and predictive of changes in dementia clinical scores and brain imaging data in subjects enrolled in the �Longitudinal studies of healthy aging and dementia�.
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Investigator: Gregory S Day
Project Title: Investigating Reliability in Reporting of Medical History in Knight ADRC Participants
Date: December 21, 2021 at 5:18 pm
Request ID: D1908
Aim 1: Determine the reliability of reported past medical history of stroke and diabetes in Knight ADRC participants.
Aim 2: Quantify the in?uence of measured variables on reliability in reporting of past medical history of stroke and diabetes in Knight ADRC participants.
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Investigator: Colin L Masters
Project Title: NIH Grant CSF Data Harmonisation
Date: December 21, 2021 at 5:18 pm
Request ID: D1907
Aim 1: Assess the biomarker trajectories of participants from AIBL, ADNI and the ACS that have at least three follow up time points
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Investigator: Catherine Roe
Project Title: Characteristics and Outcomes of Uncertain Dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1906
Aim 1: What characteristics of the participant distinguish people diagnosed with CDR 05/uncertain dementia from CDR/0 and CDR 0.5/AD individuals?
Aim 2: What characteristics of CDR 0.5/uncertain predict future progression in cognition and to AD?
Aim 3: To what extent does cognitive impairment progress over time among participants with uncertain diagnoses who do not develop AD?
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Investigator: Chihiro Sato
Project Title: Profiling CSF Tau isoforms by Mass Spectrometry for the Diagnosis of Tauopathies
Date: December 21, 2021 at 5:18 pm
Request ID: D1905
Aim 1: to collect CSF and matching plasma from various tauopathies and profile CSF tau to improve early diagnostics
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Investigator: Arthur Simen, Adam Schwarz
Project Title: Utility of a digital cognitive endpoint in early POC studies in AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1904
Aim 1: Assess patient compliance on the ARC app
Aim 2: Generate preliminary estimates of relationships between ARC measures and A/T/N biomarker classification
Aim 3: Generate preliminary estimates of how performance on the ARC app relates to performance on traditional paper and pencil cognitive measures, regional distribution of tau and/or CSF P-Tau and cortical atrophy measured at the same point in time
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Investigator: Yong Wang
Project Title: Tensor Analysis of BOLD Signals in Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1902
Aim 1: Characterize the white matter BOLD tensor in normal aging and AD
Aim 2: Evaluate the relationsihp between white matter BOLD tensor and cognitive status in AD
Aim 3: Characterize the gray matter BOLD tensor in normal aging and AD
Aim 4: Evalaute the regional BOLD tensor connectivity in normal aging and AD
Investigator: Cho-Yi Chen
Project Title: Reproduce the Results from Musiek et al. (2018): Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1901
Aim 1: Reproduce the results from Dr. Yo-El Lu’s paper in JAMA Neurology (Musiek et al., 2018) and apply the same methodology to our dataset.
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