Search Existing Data Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


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Investigator: Perrin, Richard

Project Title: Novel Fluid Biomarkers Associated with PIB-PET Imaging

Date: December 21, 2021 at 5:18 pm

Request ID: D1423

Aim 1: Identify fluid biomarkers associated with PIB positivity among CDR0 participants

Aim 2: Identify fluid biomarkers that predict conversion to PIB positivity among PIB negative CDR0 participants

Aim 3: Identify fluid biomarkers that predict progression to CDR>0 among PIB positive CDR0 participants

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Investigator: Denise Head

Project Title: Inflammation as a mediator of age, personality and exercise associations with brain structure

Date: December 21, 2021 at 5:18 pm

Request ID: D1422

Aim 1: Examine whether inflammatory markers mediate the relationships of aging, personality traits and exercise with regional brain structure.

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Investigator: John Morris

Project Title: NIA-AA staging using multiple biomarkers

Date: December 21, 2021 at 5:18 pm

Request ID: D1421

Aim 1: To comparing NIA-AA staging criterion using both CSF and imaging biomarkers

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Investigator: Carlos Cruchaga

Project Title: Identification of genetic factors associated with rate of progression

Date: December 21, 2021 at 5:18 pm

Request ID: D1420

Aim 1: To analyze whether other genetic factors associated with CSF ptau181 levels also are associated with progression rate. We are currently performing a GWAS analysis using CSF ptau181 levels as phenotype and we want to test the top hit from this analysis for association with progression rate.

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Investigator: Gregory Day

Project Title: Identifying clinical and paraclinical predictors of rate of progression in dementia (RaPID)

Date: December 21, 2021 at 5:18 pm

Request ID: D1419

Aim 1: 1. To characterize clinical and paraclinical measures in participants with suspected and/or confirmed rapidly progressive dementia.

Aim 2: 2. To identify clinical and paraclinical measures that predict final diagnoses in patients with rapidly progressive dementia.

Aim 3: 3. To identify clinical and paraclinical measures associated with rapidly progressive, typically progressive and slowly progressive dementia.

Aim 4: 4. To identify clinical and paraclinical measures that predict rate of progression in dementia.


Investigator: Linda Larson-Prior

Project Title: Geriatric Atlases for functional EEG and neurostimulation therapy of aging brains

Date: December 21, 2021 at 5:18 pm

Request ID: D1418

Aim 1: Determine whether patterns of atrophy based on CSF volume differ between adults with no amyloid burden vs a mixed population between the ages of 50-100 years

Aim 2: Define and test a morphometric feature space that describes discrete age-group clusters that differ significantly in those features

Aim 3: Create and test age-cluster head models for use in neurostimulation and electrical source imaging studies

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Investigator: Linda Larson-Prior

Project Title: Cognitrive fluctuations in aging and dementia

Date: December 21, 2021 at 5:18 pm

Request ID: D1417

Aim 1: To determine the neural network changes that differentiate individuals with cognitive fluctuations from age-matched cognitively normal adults

Aim 2: To determine whether neural network changes associated with cognitive fluctuations differ from changes in those with mild cognitive dysfunction in individuals matched by age and CDR rating

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Investigator: Dale Bredesen, M.D.

Project Title: ADAD-associated neuropathology from the NACC database

Date: December 21, 2021 at 5:18 pm

Request ID: D1416

Aim 1: Compare and contrast the prevalence of amyloid angiopathy in persons with ADAD relative to LOAD

Aim 2: Compare and contrast the prevalence of lewy body pathology in persons with ADAD relative to LOAD

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Investigator: John C Morris

Project Title: Examine neuropathological correlates of subjective memory complaints

Date: December 21, 2021 at 5:18 pm

Request ID: D1323

Aim 1: . Describe the relationship between main neuropathological findings of Alzheimer’s disease (β-amyloi

Aim 2: Clarify the role of the accompanying neuropathological findings (white matter change, ischemia, infa

Aim 3: Determine what neuropathological finding is the best candidates to explain SMC.

Aim 4: Compare other clinical and biological variables (CDR-SB, ApoE,) between participants with or without


Investigator: Julia Soscia

Project Title: An item-level analysis of frequently missed items on the Mini Mental State Exam (MMSE) in cognitively normal older adults and its relationship to future cognitive impairment.

Date: December 21, 2021 at 5:18 pm

Request ID: D1505

Aim 1: To determine which MMSE items predict future cognitive problems

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