The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Perrin, Richard
Project Title: Novel Fluid Biomarkers Associated with PIB-PET Imaging
Date: December 21, 2021 at 5:18 pm
Request ID: D1423
Aim 1: Identify fluid biomarkers associated with PIB positivity among CDR0 participants
Aim 2: Identify fluid biomarkers that predict conversion to PIB positivity among PIB negative CDR0 participants
Aim 3: Identify fluid biomarkers that predict progression to CDR>0 among PIB positive CDR0 participants
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Investigator: Denise Head
Project Title: Inflammation as a mediator of age, personality and exercise associations with brain structure
Date: December 21, 2021 at 5:18 pm
Request ID: D1422
Aim 1: Examine whether inflammatory markers mediate the relationships of aging, personality traits and exercise with regional brain structure.
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Investigator: John Morris
Project Title: NIA-AA staging using multiple biomarkers
Date: December 21, 2021 at 5:18 pm
Request ID: D1421
Aim 1: To comparing NIA-AA staging criterion using both CSF and imaging biomarkers
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Investigator: Carlos Cruchaga
Project Title: Identification of genetic factors associated with rate of progression
Date: December 21, 2021 at 5:18 pm
Request ID: D1420
Aim 1: To analyze whether other genetic factors associated with CSF ptau181 levels also are associated with progression rate. We are currently performing a GWAS analysis using CSF ptau181 levels as phenotype and we want to test the top hit from this analysis for association with progression rate.
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Investigator: Gregory Day
Project Title: Identifying clinical and paraclinical predictors of rate of progression in dementia (RaPID)
Date: December 21, 2021 at 5:18 pm
Request ID: D1419
Aim 1: 1. To characterize clinical and paraclinical measures in participants with suspected and/or confirmed rapidly progressive dementia.
Aim 2: 2. To identify clinical and paraclinical measures that predict final diagnoses in patients with rapidly progressive dementia.
Aim 3: 3. To identify clinical and paraclinical measures associated with rapidly progressive, typically progressive and slowly progressive dementia.
Aim 4: 4. To identify clinical and paraclinical measures that predict rate of progression in dementia.
Investigator: Linda Larson-Prior
Project Title: Geriatric Atlases for functional EEG and neurostimulation therapy of aging brains
Date: December 21, 2021 at 5:18 pm
Request ID: D1418
Aim 1: Determine whether patterns of atrophy based on CSF volume differ between adults with no amyloid burden vs a mixed population between the ages of 50-100 years
Aim 2: Define and test a morphometric feature space that describes discrete age-group clusters that differ significantly in those features
Aim 3: Create and test age-cluster head models for use in neurostimulation and electrical source imaging studies
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Investigator: Linda Larson-Prior
Project Title: Cognitrive fluctuations in aging and dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1417
Aim 1: To determine the neural network changes that differentiate individuals with cognitive fluctuations from age-matched cognitively normal adults
Aim 2: To determine whether neural network changes associated with cognitive fluctuations differ from changes in those with mild cognitive dysfunction in individuals matched by age and CDR rating
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Investigator: Dale Bredesen, M.D.
Project Title: ADAD-associated neuropathology from the NACC database
Date: December 21, 2021 at 5:18 pm
Request ID: D1416
Aim 1: Compare and contrast the prevalence of amyloid angiopathy in persons with ADAD relative to LOAD
Aim 2: Compare and contrast the prevalence of lewy body pathology in persons with ADAD relative to LOAD
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Investigator: John C Morris
Project Title: Examine neuropathological correlates of subjective memory complaints
Date: December 21, 2021 at 5:18 pm
Request ID: D1323
Aim 1: . Describe the relationship between main neuropathological findings of Alzheimer’s disease (β-amyloi
Aim 2: Clarify the role of the accompanying neuropathological findings (white matter change, ischemia, infa
Aim 3: Determine what neuropathological finding is the best candidates to explain SMC.
Aim 4: Compare other clinical and biological variables (CDR-SB, ApoE,) between participants with or without
Investigator: Julia Soscia
Project Title: An item-level analysis of frequently missed items on the Mini Mental State Exam (MMSE) in cognitively normal older adults and its relationship to future cognitive impairment.
Date: December 21, 2021 at 5:18 pm
Request ID: D1505
Aim 1: To determine which MMSE items predict future cognitive problems
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