The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Alison Goate/Oscar Harari
Project Title: Identification of genetic factors associated with rate of progression
Date: December 21, 2021 at 5:18 pm
Request ID: D1212
Aim 1: To replicate the association of rs1868402 with rate of progression
Aim 2: To analyze whether other genetic factors associated with CSF ptau181 levels
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Investigator: Charles DeCarli
Project Title: NACC MRI Genotype Association Studies
Date: December 21, 2021 at 5:18 pm
Request ID: D1211
Aim 1: Acquire MRI data related to TCV and Hippocampal estimates from NACC participating sites
Aim 2: Match MRI data with ADGC acquired genotype data on NACC enrolled subjects
Aim 3: Examine candidate gene associations from prior publications
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Investigator: Brooke Sadler
Project Title: The Evolutionary Role of Nicotinic Receptors in Memory and Cognitive Performance
Date: December 21, 2021 at 5:18 pm
Request ID: D1210
Aim 1: Examine association between genotypes in nicotinic receptors with phenotypes related to cognition
Aim 2: Determine if these genotypes are at different frequencies among AD vs non AD participants
Aim 3: Relate these frequency differences back to historical selective pressures on increased cognition
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Investigator: Phillip Hsu
Project Title: Risk factors associated with Headache due to Lumbar Puncture
Date: December 21, 2021 at 5:18 pm
Request ID: D1209
Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache
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Investigator: Zheyu Wang
Project Title: Biomarker Evaluation in the Absence of a Gold Standard
Date: December 21, 2021 at 5:18 pm
Request ID: D1208
Aim 1: Methodology development on evaluating biomarkers in the absence of a gold standard
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Investigator: Catherine M. Roe
Project Title: Alzheimer’s disease biomarkers and cancer
Date: December 21, 2021 at 5:18 pm
Request ID: D1207
Aim 1: To examine whether Alzheimer’s disease biomarkers are associated with cancer
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Investigator: Chengjie Xiong
Project Title: Two Preclinical Latent Scores to Predict Occurrence of DAT
Date: December 21, 2021 at 5:18 pm
Request ID: D1206
Aim 1: Assess the antecedent longitudinal changes and their predictive power of DAT for individual items of
Aim 2: Aim 2. Evaluate the use of IRT
Aim 3: Develop clinically meaningful score reports
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Investigator: David Holtzman
Project Title: Clinicopathologic Characterization of Late-Onset Autosomal Dominant AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1126
Aim 1: Identify clinical charactersitics of family LO6 who harbor PSEN1 A79V mutations
Aim 2: Examine CSF and Imaging biomarkers in individuals from family LO6
Aim 3: Compare clinical and biomarker data between LO6 and early-onset kindreds with PSEN1 A79V mut
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Investigator: Carlos Cruchaga/Alison Goate
Project Title: To test whether the poly-T polymorphism (rs10524523) is associated with change in gray matter volume
Date: December 21, 2021 at 5:18 pm
Request ID: D1125
Aim 1: Try to replicate the Dr. Sager neuroimaging findings in a larger series
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Investigator: David Holtzman/Alison Goate
Project Title: To identify genetic variation that influences VILIP1 levels in cerebrospinal fluid
Date: December 21, 2021 at 5:18 pm
Request ID: D1124
Aim 1: To identify polymorphisms that explain variability in CSF VILIP1 levels.
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