The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Zehra Onen
Project Title: Optimal Population Screening Policies for Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1514
Aim 1: To compute optimal population screening policies for Alzheimer�s Disease (AD) using Markov Decision Process (MDP) and Partially Observable MDP models.
Aim 2: To compute annual transition probabilities within AD free and preclinical stage individuals
Aim 3: To build mathematical models for biomarkers’ progression focusing on normal individuals and individuals in preclinical stages of Alzheimer’s Disease
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Investigator: Angela Curl
Project Title: Psychometric Testing of the CARS Instrument
Date: December 21, 2021 at 5:18 pm
Request ID: –
Aim 1: To test the psychometric reliability of the newly developed CARS Instrument
Aim 2: To test the psychometric validity of the newly developed CARS Instrument
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Investigator: Kirchhoff
Project Title: An Investigation of the Relationships Between Brain Structure and Attentional Control
Date: December 21, 2021 at 5:18 pm
Request ID: D1516
Aim 1: To identify brain regions that support successful attentional control processes by examining the relationships between brain structure and performance on attentional control tasks.
Aim 2: To investigate the brain structural changes that lead to attentional control impairments in Alzheimer�s Disease.
Aim 3: To examine whether brain structure at least partially mediates the relationships between AD risk and attentional control.
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Investigator: John C. Morris
Project Title: Examining the Relationship Between Depressive Symptoms and Cognitive Deficits in Preclinical Dementia of the Alzheimer Type
Date: December 21, 2021 at 5:18 pm
Request ID: D1511
Aim 1: Examine results from a psychometric battery of cognitive tests for patients with no evidience of clinical dementia
Aim 2: Asses the relationship between depression and preclinical AD through CSF samples analyzed for AD markers and PIB-PET amyloid imaging.
Aim 3: Compare antidepressive medication usage (e.g. SSRIs) to imaging data to assess the effect of medication usage on amyloid buildup.
Aim 4: To understand if those with depression and higher amyloid burden have worse cognitive performance.
Investigator: hugo vanderstichele
Project Title: CSF Biomarker analysis for to the Adult Children Study (ACS) of the Knight Alzheimer�s Disease Research Center at Washington (recently published by JAMA NEUROLOGY)
Date: December 21, 2021 at 5:18 pm
Request ID: D1510
Aim 1: AD CSF biomarker changes in cognitively normal middle-aged adults
Aim 2: Performance of individual biomarkers or combinations of biomarkers
Aim 3: Comparison of biomarkers with imaging data
Aim 4: Evaluate correlation between CSF biomarkers and cognitive performance
Investigator: Catherine Roe
Project Title: Pilot data for Sleep Aim of Preclinical AD and Driving Continuing Renewal
Date: December 21, 2021 at 5:18 pm
Request ID: D1509
Aim 1: To combine data from HASD Project 2 (Sleep study) with data from R01 AG043434-01 (Preclinical AD and Driving) for pilot data to be used in the R01 Continuing Renewal application.
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Investigator: Joan Montaner
Project Title: A NEW CHEMOKINE (CCL23) TO PREDICT MILD COGNITIVE IMPAIRMENT PROGRESSION TO ALZHEIMER DISEASE
Date: December 21, 2021 at 5:18 pm
Request ID: D1508
Aim 1: We aimed to evaluate the predictive value of CCL23 in patients with mild cognitive impairment that would develop dementia
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Investigator: Linda Larson-Prior
Project Title: Changes in Brain Network dynamics As An Index of Amyloid Status in Healthy Elders
Date: December 21, 2021 at 5:18 pm
Request ID: D1507
Aim 1: Under the hypothesis that cognitively normal individuals with either abnormal CSF protein levels of Ab/tau an imaging evidence of amyloid load will exhibit abnormalities in regional and spectral-band specific neuronal synchronization, we will collect high density electroencephalography (hd-EEG, 256
Aim 2: Under the hypothesis that early markers of impairment in working memory will manifest in frontal synchrony measured in the theta band as well as in network synchrony assessed using phase locking value, we will collect hdEEG as subjects perform a visual N-back working memory task that includes emotio
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Investigator: Julia Soscia
Project Title: An item-level analysis of frequently missed items on the Mini Mental State Exam (MMSE) in cognitively normal older adults and its relationship to future cognitive impairment.
Date: December 21, 2021 at 5:18 pm
Request ID: D1505
Aim 1: To determine which MMSE items predict future cognitive problems
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Investigator: Yvette Sheline
Project Title: Comparison of graph characteristics in resting state fMRI in LOAD and DIAN participants
Date: December 21, 2021 at 5:18 pm
Request ID: D1504
Aim 1: Determine graph characteristics (wavelet-based coherence, binary graph diagnostics, weighted and cynamic graph diagnostics in LOAD and DIAN
Aim 2: Determine similarities and differences in these graph characteristics
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