The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Jee-young Han
Project Title: Clinical outcomes and its predictors in CDR 0.5, uncertain dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1704
Aim 1: To define and differentiate clinical characteristics of CDR 0.5, uncertain dementia
Aim 2: To demonstrate the clinical outcomes of CDR 0.5, uncertain dementia
Aim 3: To determine predictors of progression of CDR 0.5, uncertain dementia to AD
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Investigator: Arnaud Charil
Project Title: Potential usage of diffusion basis spectrum imaging (DBSI) to assess white matter inflammation in Alzheimer�s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1703
Aim 1: Generate a normative profile (across brain regions/tracts and subjects) of DBSI parameters, suitable for expressing (defining) �abnormal� levels of these parameters
Aim 2: Explore the profile of abnormalities in the different DBSI parameters in more advanced NIA-AA stage individuals
Aim 3: Refine potential analysis strategies for application to clinical trials
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Investigator: Sergey Shcherbinin
Project Title: Potential usage of PET-based perfusion measurements as candidates neurodegeneration biomarkers
Date: December 21, 2021 at 5:18 pm
Request ID: D1702
Aim 1: Analyze dynamic PET images obtained using different radiotracers
Aim 2: Optimize time window to measure perfusion using PET tracers
Aim 3: Perform cross-sectional and longitudinal comparison between perfusion measures and other biomarkers/scores
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Investigator: Samantha Allison
Project Title: Relationship between proton pump inhibitors and risk of dementia, cognition, brain structure, and Alzheimer disease biomarkers
Date: December 21, 2021 at 5:18 pm
Request ID: D1701
Aim 1: Examine the relationship between proton pump inhibitors and both risk of dementia and longitudinal change in cognition.
Aim 2: Examine the relationship between proton pump inhibitors and biological markers of Alzheimer disease (e.g., regional based brain volumes obtained via structural MRI, amyloid PET, and CSF biomarkers).
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Investigator: Chengjie Xiong
Project Title: Pre-Clinical BioMarker Study
Date: December 21, 2021 at 5:18 pm
Request ID: D1628
Aim 1: Integrate biomarkers and clinical and cognitive databases from 4 sites and develop novel statistical methods for analyzing biomarkers.
Aim 2: Statistically validate the preclinical stages of AD as proposed by the National Institute on Aging�Alzheimer’s Association (NIA-AA) Workgroup (Sperling et al. 2011).
Aim 3: Optimize the design of modern randomized clinical trials (RCTs) in preclinical or early-stage AD by identifying the cognitive composite that minimizes the sample sizes required to adequately power such trials.
Aim 4: Assess how MRI white matter hyperintensities, infarcts, microbleeds, Body Mass Index (BMI) & HbA1c contribute to the preclinical changes in biomarkers and cognition, and further neuropathologically validate findings of Aim 1 & 2.
Investigator: Joshua Shimony
Project Title: Improved statistical methods for resting state fMRI analysis
Date: December 21, 2021 at 5:18 pm
Request ID: D1627
Aim 1: Confirm the utility of new statistical techniques applied to resting state analysis and confirming these methods by comparing resting state connectivity across different ADRC cohorts.
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Investigator: Chengjie Xiong
Project Title: Cross-sectional and Longitudinal Comparison of DIAN MC and those in the ACS on Biomarkers and Cognitions when Baseline Ages are Matched
Date: December 21, 2021 at 5:18 pm
Request ID: D1626
Aim 1: To compare DIAN MC to those with a positive family history in the ACS on baseline Biomarkers and Cognitions when their age were matched;
Aim 2: To compare DIAN MC to those with a positive family history in the ACS on the longitudinal rates of changes in Biomarkers and Cognitions when their baseline age were matched;
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Investigator: Teodoro Bottiglieri
Project Title: Methionine and methylation cycle metabolites in dementia.
Date: December 21, 2021 at 5:18 pm
Request ID: D1625
Aim 1: To determine and compare metabolites related to methionine metabolism and methylation in plasma and CSF from a cohort of subjects who cognitively normal and with mild dementia of the Alzheimer�s type.
Aim 2: To determine the relationship between metabolites related to homocysteine metabolism and methylation with other biomarkers of Alzheimer�s disease (i.e.ApoE genotype, beta-amyloid 1-40 and 1-42, Tau and p-Tau) in plasma and CSF.
Aim 3: To determine if metabolites of the methionine cycle and methylation are correlated with and predictive of changes in dementia clinical scores and brain imaging data in subjects enrolled in the �Longitudinal studies of healthy aging and dementia�.
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Investigator: Jason Hassenstab
Project Title: Characterization of Cognitive Aging in a Robust Sample of Healthy Older Adults
Date: December 21, 2021 at 5:18 pm
Request ID: D1624
Aim 1: Detemine the contribution of normal aging on cognitive trajectories in biomarker positive cognitively normal adults compared to biomarker negative older adults.
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Investigator: Brian Gordon
Project Title: PET tau results sharing
Date: December 21, 2021 at 5:18 pm
Request ID: D1610
Aim 1: Share data images from a publication with NeuroVault.org
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