The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Dr Noel Faux
Project Title: Replicating and evaluating blood-based AD risk signatures
Date: [153]
Request ID: D1903
Aim 1: To replicate our blood-based predictive models of CSF AB 1-42 and tau
Aim 2: To evaluate the prognostic and clinical utility of our blood-based predictive models
Aim 3: Determine the utility of genomic risk scores when predicting CSF biomarkers
Aim 4: Evaluate the ability to predict other CSF based biomarkers
Investigator: Yong Wang
Project Title: Tensor Analysis of BOLD Signals in Alzheimer’s Disease
Date: [153]
Request ID: D1902
Aim 1: Characterize the white matter BOLD tensor in normal aging and AD
Aim 2: Evaluate the relationsihp between white matter BOLD tensor and cognitive status in AD
Aim 3: Characterize the gray matter BOLD tensor in normal aging and AD
Aim 4: Evalaute the regional BOLD tensor connectivity in normal aging and AD
Investigator: Cho-Yi Chen
Project Title: Reproduce the Results from Musiek et al. (2018): Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease
Date: [153]
Request ID: D1901
Aim 1: Reproduce the results from Dr. Yo-El Lu’s paper in JAMA Neurology (Musiek et al., 2018) and apply the same methodology to our dataset.
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Investigator: Gregory S Day
Project Title: Tau imaging in autoimmune encephalitis associated with LGI1 autoantibodies
Date: [153]
Request ID: D1832
Aim 1: To report on patterns of tau PET imaging (AV1451) that distinguish patients with LGI1 encephalitis from controls and patients with symptomatic AD.
Aim 2: To determine sensitivity of tau PET imaging (AV1451) for AD neuropathologic change in LGI1 encephalitis patients that come to autopsy.
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Investigator: Ellen Grober, PhD.
Project Title: Stages of Objective Memory Impairment (SOMI) and the A/T/N scheme
Date: [153]
Request ID: D1831
Aim 1: To explore the relationship of FR, TR and the SOMI system with CSF markers of amyloid-β 1-42 (Aβ42), total tau (t-tau), phosphorylated tau (p-tau), and with hippocampal volume (HCV), a marker of neurodegeneration in the A/T/N system.
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Investigator: Michael Weiner
Project Title: Development of an eCDR as an Online Instrument for Screening Elders at Risk for AD
Date: [153]
Request ID: D1830
Aim 1: Select items in CDR that are most strongly associated with CDR global score and CDR sum of boxes
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Investigator: Guoqiao Wang
Project Title: Joint Modeling of baseline performance, longitudinal change and within-subject variability in cognition on risk of developing Alzheimer disease.
Date: [153]
Request ID: D1829
Aim 1: utilize a joint modeling procedure to simultaneously estimate the influence of baseline cognitive performance and the rate of cognitive decline on the years remaining until the onset of clinical symptoms in sporadic Alzheimer disease (AD)
Aim 2: determine the extent to which within-person fluctuation in cognitive scores is predictive of number of years to symptom onset
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Investigator: Bernard Mulvey
Project Title: Massively parallel reporter assay to detect functional variants and sex-differential transcriptional regulators in depression-associated GWAS loci
Date: [153]
Request ID: D1828
Aim 1: AAV8 transduction of iPSC-derived neural progenitors to screen for functional and/or sex-differential regulators and regulatory variants in depression GWAS haplotype blocks
Aim 2: AAV8 transduction of iPSC-derived neural progenitors to assess sex-differential activity of noncoding sequence motifs near sex-differentially expressed genes in mouse locus coeruleus neurons
Aim 3: AAV8 transduction of iPSC-derived neural progenitors to identify proximal (<15kb from TSS) regulatory elements near putative targets of variants in Aim 1
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Investigator: Andy Aschenbrenner
Project Title: Relationship between functional connectivity and cognition in sporadic and autosomal dominant Alzheimer disease
Date: [153]
Request ID: D1827
Aim 1: evaluate how functional connectivity relates to cognition in AD
Aim 2: compare the relationship across LOAD and ADAD
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Investigator: Justin M Long
Project Title: Longitudinal Outcomes in Preclinical Alzheimer Disease
Date: [153]
Request ID: D1826
Aim 1: To determine the ultimate clinical and neuropathological outcomes (when available) among patients in the MAP cohort with preclinical AD, as defined by normal cognition and amyloid biomarker positivity (either amyloid PET imaging or CSF biomarker measurements)
Aim 2: To quantify the proportion of participants with preclinical AD that convert to symptomatic AD and the variability in rate of conversion. To identify factors that increase risk of conversion and factors that contribute to resilience in non-converters.
Aim 3: To identify putative risk factors that predict conversion from biomarker negativity to preclinical AD
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