The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Andy Aschenbrenner
Project Title: Modeling Age of Onset of Demenita in Sporadic Alzheimer Disease
Date: [153]
Request ID: D1825
Aim 1: Determine trajectories of cognitive decline prior to diagnosis as a function of age and APOE
Aim 2: Develop a predictive model of age of onset as a function of age, amyloid and APOE
Aim 3: Apply the predictive model to various AD cohorts to assess generalizability and vailidity.
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Investigator: Tammie Benzinger
Project Title: PK11195 PET Imaging of Inflammation in Aging and DAT: Data Analysis Only
Date: [153]
Request ID: D1824
Aim 1: Determine if elevation of PET 11C-PK11195 uptake, a biomarker of neuroinflammation, is associated with cerebrovascular small vessel disease risk factors, white matter hyperintensity burden and white matter disruption.
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Investigator: Albert Davis
Project Title: Effect of APOE genotype of progression of dementia in Parkinson disease and dementia with Lewy bodies
Date: [153]
Request ID: D1823
Aim 1: The goal of this project is to determine if APOE genotype affects rate of progression of dementia in patients with dementia with Lewy bodies and Parkinson disease dementia.
Aim 2: A secondary goal is to determine if APOE genotype differentially affects rate of dementia progression in DLB/PDD individuals with alpha-synuclein pathology vs. a combination of alpha-synuclein and amyloid-beta pathology.
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Investigator: Benzinger (Imaging Core) / Morris
Project Title: Laterality of Tau and Amyloid Deposition
Date: [153]
Request ID: D1822
Aim 1: Examine the asymmetric relationship of PiB and AV45 labeled amyloid, and AV1451 labeled tau
Aim 2: Correlate amyloid and tau asymmetry with neuropsychiatric, cognitive, and psychmetric measures
Aim 3: Explore relationship of demographic measures to tau and amyloid asymmetry
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Investigator: Kun Hu
Project Title: Neuropathology for disrupted multiscale activity control in Alzheimer�s disease
Date: [153]
Request ID: D1821
Aim 1: Examine the association of AD pathology with MAC in preclinical AD.
Aim 2: Determine the interaction effect of MAC degradation and AD pathology on cognition.
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Investigator: Randall Bateman
Project Title: Longitudinal Tau SILK- Tau PET
Date: [153]
Request ID: D1820
Aim 1: To quantify longitudinal changes (>1 year) of Tau SILK and Tau PET measures in 16 CDR=0 and 16 CDR>0 participants who have completed 1st tau SILK and 1st tau PET imaging
Aim 2: For the consortium members to independently process and analyze tau SILK, MRI, florbetapir and flortaucipir (DICOM) data to explore their questions of interest
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Investigator: Timothy J. Hohman
Project Title: Genetic Drivers of Resilience to Alzheimer’s Disease
Date: [153]
Request ID: D1819
Aim 1: Perform a GWAS to identify common genetic variants that predict resilience in the presence of AD biomarkers.
Aim 2: Perform an imputed gene expression analyses using the PrediXcan methodology to identify genes associated with resilience.
Aim 3: Perform a sex-stratified GWAS to identify sex-specific genetic drivers of resilience to AD biomarkers.
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Investigator: Jonathan McConathy
Project Title: Predicting brain tau status with flow parameters derived from dynamic amyloid PET
Date: [153]
Request ID: D1818
Aim 1: Determine appropriate flow phase parameters and estimated cerebral blood flow quantification from dynamic amyloid-PET to optimally stratify amyloid+ participants into tau+ and tau- cohorts
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Investigator: Mark Bondi
Project Title: Imaging tau accumulation in the locus coeruleus
Date: [153]
Request ID: D1817
Aim 1: Examine differences in tau PET in the locus coeruleus between older adults with normal cognition, MCI, and AD
Aim 2: Examine differences in tau PET in the locus coeruleus between biomarker (e.g., amyloid PET, CSF p-tau, subtle cognitive decline) positive and negative individuals
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Investigator: Karin Meeker
Project Title: The Relationship Between Functional Brain Networks and Cognitive Intraindividual Variability in Healthy Aging and Early Alzheimer Disease
Date: [153]
Request ID: D1816
Aim 1: Assess magnitude of DAN- DMN anticorrelations at rest in relation to IIV across cognitive domains in healthy individuals, as well as those with early AD.
Aim 2: Repeat and compare analysis to previous ADNI study
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