The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Paul Kotzbauer
Project Title: Neurochemical Correlates of Cognitive Phenotypes of Parkinson Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1112
Aim 1: To determine whether regional neurotransmitter deficits correlate with cognitive phenotypes in PDe
Aim 2:
Aim 3:
Aim 4:
Investigator: Tim West, PhD
Project Title: Test Performance of a Novel Multiplex Assay to Quantify AD Biomarkers Within Cerebrospinal Fluid
Date: December 21, 2021 at 5:02 pm
Request ID: T1113
Aim 1: Correlate concentrations measured by ELISA and SISAQ for Tau and Aβ 40 and 42
Aim 2: Compare the reproducibility of ELISA measures with SISAQ measures
Aim 3: Measure how well SISAQ measures distinguish individuals with disease pathology from those without
Aim 4:
Investigator: Randall J Bateman
Project Title: Amyloid-Beta Metabolism in Familial Adult Children Study
Date: December 21, 2021 at 5:02 pm
Request ID: T1203
Aim 1: Measure production rates of Amyloid-beta protein isoforms in mutation carriers
Aim 2:
Aim 3:
Aim 4:
Investigator: Robert Siman
Project Title: A panel of neurodegeneration biomarkers for Alzheimer’s progression
Date: December 21, 2021 at 5:02 pm
Request ID: T1204
Aim 1: Evaluate CSF levels of 7 neurodegeneration biomarkers in relation to neurocognitive status
Aim 2: Compare CSF neurodegeneration biomarker levels with biomarker evidence for AD neuropathology
Aim 3:
Aim 4:
Investigator: Joel Perlmutter, MD
Project Title: Use of PIB Imaging to Evaluate Dementia Subtypes in People with Parkinson Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1205
Aim 1: To determine whether or not Alzheimer and Lewy body dementia have different cortical PIB uptake
Aim 2: To determine whether or not PIB uptake correlates with the presence of symptoms in AD and Lewy body.
Aim 3: To determine whether or not Amyloid Beta, Tau and Alpha Synuclein are present in the spinal fluid.
Aim 4: To determine whether elevated PIB uptake identifes a population most at risk for dementia.
Investigator: Stephen Graves, John Kauwe
Project Title: Serum Biomarkers for Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1206
Aim 1: To validate putative serum biomarkers in an independent series.
Aim 2:
Aim 3:
Aim 4:
Investigator: Marc Diamond
Project Title: Testing for tau aggregate seeding activity in CSF as a possible AD biomarker
Date: December 21, 2021 at 5:02 pm
Request ID: T1208
Aim 1: Test whether a novel tissue culture assay can detect tau aggregate seeds specifically in AD samples
Aim 2:
Aim 3:
Aim 4:
Investigator: Anne Fagan and Hideaki Bujo
Project Title: Soluble LR11 (sLR11) as a potential CSF biomarker of AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1207
Aim 1: Test ability of CSF sLR11 to distinguish cognitively normal individuals from DAT
Aim 2: Investigation the relationship between sLR11 and Ab42
Aim 3: Future: utility of sLR11 as a prognostic biomarker of future cognitive decline in CDR 0
Aim 4:
Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with cerebrospinal fluid granulin levels (Amendment)
Date: December 21, 2021 at 5:02 pm
Request ID: T1209
Aim 1: To identify genetic variants associated with CSF GRN levels through a genome-wide association study
Aim 2:
Aim 3:
Aim 4:
Investigator: Dr. John Hardy
Project Title: Genome wide association studies (GWAS) for Frontotemporal-dementia (FTD).
Date: December 21, 2021 at 5:02 pm
Request ID: T1210
Aim 1: Identification of common variants associated with FTD
Aim 2:
Aim 3:
Aim 4: