The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Robert Siman
Project Title: A panel of neurodegeneration biomarkers for Alzheimer’s progression
Date: December 21, 2021 at 5:02 pm
Request ID: T1204
Aim 1: Evaluate CSF levels of 7 neurodegeneration biomarkers in relation to neurocognitive status
Aim 2: Compare CSF neurodegeneration biomarker levels with biomarker evidence for AD neuropathology
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Investigator: Stephen is the PI of the UL grant; Wingo is the PI of the URC/ASCTI grant
Project Title: Autosomal Recessive Causes of Early-onset Alzheimer’s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1223
Aim 1: Our overarching aim is to test the hypothesis that early-onset Alzheimer’s disease (AD) has autosoma
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Investigator: Elliott Mufson
Project Title: CSF proNGF: a putative biomarker for Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1222
Aim 1: We will test whether CSF levels of proNGF are predicitve or prodromal AD.
Aim 2: Test whether CSF proNGF levels improve the diagnostic accuracy of CSF tau/Abeta
Aim 3: Test whether CSF proNGF levels correlate with antemortem measures of cognitive decline.
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Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with cerebrospinal fluid granulin levels (Amendment)
Date: December 21, 2021 at 5:02 pm
Request ID: T1209
Aim 1: To identify genetic variants associated with CSF GRN levels through a genome-wide association study
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Investigator: Anja Schneider/Andre Fischer
Project Title: Genome-wide profiling of CSF miRNA expression in antecedent AD using next generatio
Date: December 21, 2021 at 5:02 pm
Request ID: T1221
Aim 1: next generation deep sequencing of CSF miRNAome
Aim 2: Identification of antecedent miRNA biomarkers to predict later AD
Aim 3: Identify longitudinal changes in CSF miRNAome accompagnying preclinical AD
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Investigator: Jose Bras
Project Title: Role of Genomic variability in Lewy Body dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1220
Aim 1: Identification of genetic variability conferring risk for DLB
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Investigator: Joel Perlmutter, MD
Project Title: Use of PIB Imaging to Evaluate Dementia Subtypes in People with Parkinson Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1205
Aim 1: To determine whether or not Alzheimer and Lewy body dementia have different cortical PIB uptake
Aim 2: To determine whether or not PIB uptake correlates with the presence of symptoms in AD and Lewy body.
Aim 3: To determine whether or not Amyloid Beta, Tau and Alpha Synuclein are present in the spinal fluid.
Aim 4: To determine whether elevated PIB uptake identifes a population most at risk for dementia.
Investigator: Stephen Graves, John Kauwe
Project Title: Serum Biomarkers for Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1206
Aim 1: To validate putative serum biomarkers in an independent series.
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Investigator: Marc Diamond
Project Title: Testing for tau aggregate seeding activity in CSF as a possible AD biomarker
Date: December 21, 2021 at 5:02 pm
Request ID: T1208
Aim 1: Test whether a novel tissue culture assay can detect tau aggregate seeds specifically in AD samples
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Investigator: Anne Fagan and Hideaki Bujo
Project Title: Soluble LR11 (sLR11) as a potential CSF biomarker of AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1207
Aim 1: Test ability of CSF sLR11 to distinguish cognitively normal individuals from DAT
Aim 2: Investigation the relationship between sLR11 and Ab42
Aim 3: Future: utility of sLR11 as a prognostic biomarker of future cognitive decline in CDR 0
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