The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Anja Schneider/Andre Fischer
Project Title: Genome-wide profiling of CSF miRNA expression in antecedent AD using next generatio
Date: December 21, 2021 at 5:02 pm
Request ID: T1221
Aim 1: next generation deep sequencing of CSF miRNAome
Aim 2: Identification of antecedent miRNA biomarkers to predict later AD
Aim 3: Identify longitudinal changes in CSF miRNAome accompagnying preclinical AD
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Investigator: Jose Bras
Project Title: Role of Genomic variability in Lewy Body dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1220
Aim 1: Identification of genetic variability conferring risk for DLB
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Investigator: Paul Kotzbauer
Project Title: Neurochemical Correlates of Cognitive Phenotypes of Parkinson Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1112
Aim 1: To determine whether regional neurotransmitter deficits correlate with cognitive phenotypes in PDe
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Investigator: Oscar Alzate
Project Title: Biomarkers of Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1111
Aim 1: To identify differential regulation of protein isoforms of APO family of proteins
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Investigator: Wyss-Coray
Project Title: The plasma proteome of secreted signaling proteins in people with pathological biomarkers for AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1110
Aim 1: To measure the plasma communicome associated with amyloid-positivity in cognitively normal individua
Aim 2: To discover biological pathways associated with amyloid-positivity in cognitively normals
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Investigator: Dr. John Hardy
Project Title: Whole-exome sequencing of autopsy confirmed samples to identify rare variants implicated on AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1201
Aim 1: The aim of this study is to identify rare alleles of large effects on risk for Alzheimer’s Disease
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Investigator: Randall J Bateman
Project Title: Amyloid-Beta Metabolism in Familial Adult Children Study
Date: December 21, 2021 at 5:02 pm
Request ID: T1203
Aim 1: Measure production rates of Amyloid-beta protein isoforms in mutation carriers
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Investigator: Joel Perlmutter, MD
Project Title: Use of PIB Imaging to Evaluate Dementia Subtypes in People with Parkinson Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1205
Aim 1: To determine whether or not Alzheimer and Lewy body dementia have different cortical PIB uptake
Aim 2: To determine whether or not PIB uptake correlates with the presence of symptoms in AD and Lewy body.
Aim 3: To determine whether or not Amyloid Beta, Tau and Alpha Synuclein are present in the spinal fluid.
Aim 4: To determine whether elevated PIB uptake identifes a population most at risk for dementia.
Investigator: Stephen Graves, John Kauwe
Project Title: Serum Biomarkers for Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1206
Aim 1: To validate putative serum biomarkers in an independent series.
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Investigator: Tim West, PhD
Project Title: Test Performance of a Novel Multiplex Assay to Quantify AD Biomarkers Within Cerebrospinal Fluid
Date: December 21, 2021 at 5:02 pm
Request ID: T1113
Aim 1: Correlate concentrations measured by ELISA and SISAQ for Tau and Aβ 40 and 42
Aim 2: Compare the reproducibility of ELISA measures with SISAQ measures
Aim 3: Measure how well SISAQ measures distinguish individuals with disease pathology from those without
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