The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Gregory J. Zipfel
Project Title: STAT3 activation and neurovascular dysfunction in Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1409
Aim 1: We plan to study the phosphorylation and acetylation of STAT3 in the blood vessels isolated from human AD brains
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Investigator: Manuel Sarasa
Project Title: The kinetics of the plasma Aβ biomarkers (Aβ42, Aβ40) in the Adult Children Study (ACS).
Date: December 21, 2021 at 5:02 pm
Request ID: T1402
Aim 1: To measure the levels of Aβ plasma markers (DA and RP for Aβ42, Aβ40) in the ACS cohort.
Aim 2: To identify which demographic (age, family history, ApoE genotype, sex, years of education) hematological (hematocrit, blood cell counts, if available in ACS database) and serum biochemical covariables (creatinine, homocysteine, urea, uric acid, hemoglobin, and serum total proteins, if available
Aim 3: Alternatively, these analysis could be performed at Araclon’s lab if a frozen serum sample would be provided) are significantly associated with the levels of Aβ plasma markers in the ACS cohort. Those statistical significant correlates should be included as potential confounding factors in the multi
Aim 4: To describe the progression of plasma Aβ biomarkers over time in each subject and the variation in the trajectories between subjects in a model adjusted for the relevant confounding factors.
Investigator: Sidney Strcikland
Project Title: Identification of a Plasmin-Resistant Fibrin Fragment as a Biomarker for Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1320
Aim 1: Determine a level of plasmin-resistant fibrin fragment in CSF from AD patients
Aim 2: The relationship between a level of Fibrin Fragment and pathological characteristics of AD patients
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Investigator: Makoto Ishii
Project Title: Altered leptin signaling in Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1318
Aim 1: To determine if alterations in leptin signaling are found in earliest stages of Alzheimer’s disease
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Investigator: David Holtzman
Project Title: : Synuclein seed detection in brains of patients with synucleinopathies
Date: December 21, 2021 at 5:02 pm
Request ID: T1319
Aim 1: Detect synuclein seeds in brain tissue of different synucleinopathies
Aim 2: Determine if there are unique conformers of synuclein in the different synucleinopathies
Aim 3: Determine if there is regional specificity of synuclein conformers
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Investigator: Joel Kramer
Project Title: Disease-free Aging Control Group for Tau Consortium Genetic Studies
Date: December 21, 2021 at 5:02 pm
Request ID: T1321
Aim 1: provide DNA from functionally normal controls without family history of neurodegenerative disease
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Investigator: Marc I. Diamond
Project Title: Characterizing tau aggregate species via structural mapping
Date: December 21, 2021 at 5:02 pm
Request ID: T1322
Aim 1: Cluster tauopathy patients in clinically meaningful ways via structural mapping of tau aggregates.
Aim 2: Determine if disease progression rates are influenced by tau aggregate protein structure.
Aim 3: Determine if tau aggregate protein structure is consistent between brain regions.
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Investigator: Langford
Project Title: importance of PINCH protein levels in CSF in AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1323
Aim 1: do levels of PINCH protein in CSF correspond to neurocognitive status in AD
Aim 2: do levels of PINCH protein in CSF correspond to immune system functional status
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Investigator: Yueming Li
Project Title: regulation and function of γ-secretase
Date: December 21, 2021 at 5:02 pm
Request ID: T1324
Aim 1: Determine the function of g-secretase in Sporadic Alzheimer disease
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Investigator: Goate/Cruchaga
Project Title: Whole-exome sequencing of early-onset samples to identify rare variants implicated on Alzheimer’s Disease.
Date: December 21, 2021 at 5:02 pm
Request ID: T1401
Aim 1: To identify novel genes and coding variants implicated on Alzheimer’s disease risk
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