The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Marc I. Diamond
Project Title: Characterizing tau aggregate species via structural mapping
Date: December 21, 2021 at 5:02 pm
Request ID: T1322
Aim 1: Cluster tauopathy patients in clinically meaningful ways via structural mapping of tau aggregates.
Aim 2: Determine if disease progression rates are influenced by tau aggregate protein structure.
Aim 3: Determine if tau aggregate protein structure is consistent between brain regions.
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Investigator: Langford
Project Title: importance of PINCH protein levels in CSF in AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1323
Aim 1: do levels of PINCH protein in CSF correspond to neurocognitive status in AD
Aim 2: do levels of PINCH protein in CSF correspond to immune system functional status
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Investigator: Yueming Li
Project Title: regulation and function of γ-secretase
Date: December 21, 2021 at 5:02 pm
Request ID: T1324
Aim 1: Determine the function of g-secretase in Sporadic Alzheimer disease
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Investigator: Goate/Cruchaga
Project Title: Whole-exome sequencing of early-onset samples to identify rare variants implicated on Alzheimer’s Disease.
Date: December 21, 2021 at 5:02 pm
Request ID: T1401
Aim 1: To identify novel genes and coding variants implicated on Alzheimer’s disease risk
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Investigator: Manuel Sarasa
Project Title: The kinetics of the plasma Aβ biomarkers (Aβ42, Aβ40) in the Adult Children Study (ACS).
Date: December 21, 2021 at 5:02 pm
Request ID: T1402
Aim 1: To measure the levels of Aβ plasma markers (DA and RP for Aβ42, Aβ40) in the ACS cohort.
Aim 2: To identify which demographic (age, family history, ApoE genotype, sex, years of education) hematological (hematocrit, blood cell counts, if available in ACS database) and serum biochemical covariables (creatinine, homocysteine, urea, uric acid, hemoglobin, and serum total proteins, if available
Aim 3: Alternatively, these analysis could be performed at Araclon’s lab if a frozen serum sample would be provided) are significantly associated with the levels of Aβ plasma markers in the ACS cohort. Those statistical significant correlates should be included as potential confounding factors in the multi
Aim 4: To describe the progression of plasma Aβ biomarkers over time in each subject and the variation in the trajectories between subjects in a model adjusted for the relevant confounding factors.
Investigator: Mathew Blurton-Jones
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Date: December 21, 2021 at 5:02 pm
Request ID: T1404
Aim 1: Generation, gene-correction, and microglial differentiation of iPSC clones from patients with the AD-associated R47H TREM2 mutation.
Aim 2: Do mutations in TREM2 alter the activation state, migration, or phagocytic activity of human microglia?
Aim 3: Do TREM2 mutations alter microglial function and modulate Abeta and tau pathology in vivo?
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Investigator: Kukull (Penn)
Project Title: Validation of non-amyloid, non-Tau CSF biomarkers of Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1403
Aim 1: Aim 1: We will validate 12 non-amyloid, non-Tau CSF biomarkers of AD in samples from subjects with normal cognition, AD, and non-AD dementias, longitudinally followed at the three Centers (WU, Penn, Emory).
Aim 2: Aim 2: We will identify non-amyloid, non-Tau biomarkers suitable as staging and progression biomarkers in AD, evaluate their specificity for AD vs non-AD dementias, and evaluate the technical variability of the relevant assays across three independent Centers.
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Investigator: Cruchaga/Sands
Project Title: Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance (Amendment)
Date: December 21, 2021 at 5:02 pm
Request ID: T1108-A
Aim 1: to identify the causative variant of Kufs’ disease
Aim 2: to characterize the causative mutations
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Investigator: Eric J Kremer
Project Title: Screen for a biomarker in early satges of late-onset AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1405
Aim 1: Screen CSF from AD patients for the presence of a cleaved presynaptic protein diminished in early satges of late onset AD
Aim 2: Screen AD SGZ for the presence of a cell adhesion molecule diminished in early satges of late onset AD
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Investigator: Dr. Tom Montine
Project Title: : Neuropathological assessments of fibrillar amyloid burden in APOE e4 carriers and non-carriers with the clinical diagnosis of Alzheimer’s dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1406
Aim 1: . In this study, NACC data will be used to compare the proportions of expired brain donors with the clinical diagnosis of Alzheimer’s dementia in terms of their fibrillar amyloid burden and other neuropathologic features
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