The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Christoph Laske
Project Title: Inflammatory profiling in plasma and cerebrospinal fluid in amyloid positive vs. amyloid negative cognitively normal elderly individuals
Date: December 21, 2021 at 5:02 pm
Request ID: T1507
Aim 1: To compare systemic and CNS inflammatory biomarkers between amyloid positive (preclinical AD) vs. amyloid negative cognitively normal elderly individuals
Aim 2: To determine the association between systemic & CNS inflammatory biomarkers & clinical parameters (age, gender, education), biochemical biomarkers (CSF levels of Abeta 1-42, Tau & pTau181) & neuro-imaging biomarkers (cortical PiB-PET) in amyloid positive vs. negative cognitively normal individuals
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Investigator: Sally Temple
Project Title: iPSC Line Generation to Develop the Tau Consortium Collection
Date: December 21, 2021 at 5:02 pm
Request ID: T1506
Aim 1: To generate iPSC from MAPT mutation carriers and related non-carriers
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Investigator: Timothy M. Miller
Project Title: Determining whether cholinergic-related miRNAs are biomarkers for AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1505
Aim 1: Compare miRNA levels in CSF from controls versus CDR 0.5-1.0
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Investigator: David L. Brody
Project Title: Identification of the toxic component of Alzheimer patient-derived soluble beta-amyloid oligomers
Date: December 21, 2021 at 5:02 pm
Request ID: T1504
Aim 1: Immunopurification and identification via mass spectrometry of the specific beta-amyloid isoforms and co-associated proteins of soluble beta-amyloid oligomers derived from post-mortem Alzheimer’s neocortex.
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Investigator: Perrin, Richard
Project Title: CSF Biomarker Discovery for AD vs PDD
Date: December 21, 2021 at 5:02 pm
Request ID: T1313-A
Aim 1: Identify novel CSF biomarkers for staging AD and PD/PDD
Aim 2: Identify novel CSF biomarkers for differential diagnosis of AD vs PDD
Aim 3: Identify novel prognostic CSF biomarkers for conversion to PIB+ and CDR>0
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Investigator: Celeste Karch
Project Title: PLD3 function in the lysosome
Date: December 21, 2021 at 5:02 pm
Request ID: T1413-A
Aim 1: To determine whether PLD3 risk variants alter PLD3 localization and/or lysosomal function in human brains
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Investigator: Kelvin Yamada
Project Title: CSF orexin in postmenopausal insomnia
Date: December 21, 2021 at 5:02 pm
Request ID: T1502
Aim 1: Determine if CSF orexin is elevated in postmenopausal women
Aim 2: Determine if CSF orexin levels by ELISA are accurately reflected by serum orexin levels
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Investigator: Rosa Rademakers
Project Title: Identification of new genetic causes of Early Onset Alzheimer Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1501
Aim 1: Genetic screening of early onset alzheimer disease patients
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Investigator: Marni Uger PhD
Project Title: CSF Abeta oligomer quantification by EP-AD, a novel proprietary assay
Date: December 21, 2021 at 5:02 pm
Request ID: T1425
Aim 1: EP-AD CSF oligomers in AD, MCI and cognitively normal aging
Aim 2: EP-AD CSF oligomer concentration and cognitive, imaging, and biochemical biomarker correlation
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Investigator: John A. Kessler
Project Title: Cell autonomous mechanisms of Apolipoprotein E isoform-dependent neurodegeneration
Date: December 21, 2021 at 5:02 pm
Request ID: T1424
Aim 1: Generate isogenic APOE iPSCs from sporadic AD patients and healthy controls.
Aim 2: Evaluate whether calcium dysregulation contributes to increased excitotoxic response in E4- BFCNs.
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