The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Sherry Ferguson
Project Title: Alzheimer�s disease (AD) in African Americans and Caucasians: Comparisons of biomarkers of inflammation in human tissues.
Date: December 21, 2021 at 5:02 pm
Request ID: T1509
Aim 1: Determine race-related differences in cytokine profiles of African Americans and Caucasians with AD
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Investigator: John Morris/Nigel Cairns
Project Title: Multimodal Characterization of Hippocampal Sclerosis
Date: December 21, 2021 at 5:02 pm
Request ID: T1510
Aim 1: determine the distinguishing immunohistochemical features of HS in comparison with AD and normal aging (to include stereological assessment of neuronal loss across the entire hippocampus into the entorhinal cortex; TDP43 severity, distribution, and type of inclusions; gliosis; concomitant pathologi
Aim 2: is to determine the clinical features of HS as distinguished from AD and aging
Aim 3: determine the distinguishing biomarker features (MRI; CSF; etc) of HS in comparison with AD and aging
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Investigator: Alison Goate
Project Title: Molecular correlates of Alzheimer’s neuropathology in non-demented individuals
Date: December 21, 2021 at 5:02 pm
Request ID: T1511
Aim 1: Identify gene expression and DNA methylation correlates of amyloid plaques, neurofibrillary tangles, and cell numbers in non-demented individuals
Aim 2: Identify microglial-specific molecular correlates of Alzheimer�s neuropathology in non-demented individuals
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Investigator: Perrin, Richard
Project Title: CSF Biomarker Discovery for AD vs PDD
Date: December 21, 2021 at 5:02 pm
Request ID: T1313-A
Aim 1: Identify novel CSF biomarkers for staging AD and PD/PDD
Aim 2: Identify novel CSF biomarkers for differential diagnosis of AD vs PDD
Aim 3: Identify novel prognostic CSF biomarkers for conversion to PIB+ and CDR>0
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Investigator: Professor Emmanuel Mignot
Project Title: Analysis of hypocretin/orexin and Abeta42 levels in the cerebrospinal fluid of Alzheimer’s patients and for Genome-wide association analysis
Date: December 21, 2021 at 5:02 pm
Request ID: T1503
Aim 1: Assess differences between hypocretin/orexin levels between Alzheimer’s disease patients and controls.
Aim 2: Determine if there is a relationship between hypocretin/orexin levels and Abeta42 levels in the CSF.
Aim 3: Assess hypocretin levels and determine if GWAS analysis reveals any genetic changes in orexin levels.
Aim 4: Determine if results from Aim #3 overlap with genetic changes found that regulate Abeta42.
Investigator: Celeste Karch
Project Title: PLD3 function in the lysosome
Date: December 21, 2021 at 5:02 pm
Request ID: T1413-A
Aim 1: To determine whether PLD3 risk variants alter PLD3 localization and/or lysosomal function in human brains
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Investigator: Kelvin Yamada
Project Title: CSF orexin in postmenopausal insomnia
Date: December 21, 2021 at 5:02 pm
Request ID: T1502
Aim 1: Determine if CSF orexin is elevated in postmenopausal women
Aim 2: Determine if CSF orexin levels by ELISA are accurately reflected by serum orexin levels
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Investigator: Rosa Rademakers
Project Title: Identification of new genetic causes of Early Onset Alzheimer Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1501
Aim 1: Genetic screening of early onset alzheimer disease patients
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Investigator: Marni Uger PhD
Project Title: CSF Abeta oligomer quantification by EP-AD, a novel proprietary assay
Date: December 21, 2021 at 5:02 pm
Request ID: T1425
Aim 1: EP-AD CSF oligomers in AD, MCI and cognitively normal aging
Aim 2: EP-AD CSF oligomer concentration and cognitive, imaging, and biochemical biomarker correlation
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Investigator: John A. Kessler
Project Title: Cell autonomous mechanisms of Apolipoprotein E isoform-dependent neurodegeneration
Date: December 21, 2021 at 5:02 pm
Request ID: T1424
Aim 1: Generate isogenic APOE iPSCs from sporadic AD patients and healthy controls.
Aim 2: Evaluate whether calcium dysregulation contributes to increased excitotoxic response in E4- BFCNs.
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