The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: David Holtzman
Project Title: Measurement of soluble tau in human brain
Date: December 21, 2021 at 5:02 pm
Request ID: T1517
Aim 1: measure tau levels in human brain from controls, Alzheimer’s disease, and CBD/PSP
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Investigator: Suzanne Schindler
Project Title: Correlates of longitudinal change in CSF biomarkers
Date: December 21, 2021 at 5:02 pm
Request ID: T1516
Aim 1: Characterization of intra-individual CSF biomarker changes
Aim 2: Correlation of CSF and imaging biomarkers of neurodegeneration
Aim 3: CSF biomarkers predict cognitive performance
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Investigator: Jarret Glasscock
Project Title: Circular RNAs as novel biomarkers of Alzheimer’s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1515
Aim 1: Identify Alzheimer�s specific circRNA in the CSF of patients with AD
Aim 2: Determine whether the levels of molecules in the circulating RNA panel are also elevated in a paired serum sample
Aim 3: Determine whether the circRNA panel can be used for early diagnosis of Alzheimer�s Disease
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Investigator: NJ Cairns
Project Title: Restoring progranulin in frontotemporal disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1514
Aim 1: To determine the efficacy of lead molecules in modulating progranulin in patient-derived cells
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Investigator: Randall J. Bateman
Project Title: Stable isotope labeling & quantitative mass spectrometry imaging of amyloid-beta (A�) plaque deposition in human Alzheimer�s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1513
Aim 1: Acquire in vivo stable isotope labeled images of A� plaques in human AD brain utilizing a validated NanoSIMS imaging protocol.
Aim 2: Develop a computational mathematical framework that accurately quantifies 13C6-leucine-labeled protein deposition into plaques
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Investigator: John Crary
Project Title: Neuropathological studies of primary age-related tauopathy: the PART working group
Date: December 21, 2021 at 5:02 pm
Request ID: T1512
Aim 1: Aim 1. To validate the neuropathological criteria for PART and lay the groundwork for clinical and mechanistic studies that will elucidate disease burden, pathogenesis and progression.
Aim 2: Aim 2. To test the hypothesis that PART has a molecular signature consisting of AD-type tau pathology alongside non-amyloidogenic APP metabolites.
Aim 3: Aim 3. To test the hypothesis that PART has a genetic risk profile that overlaps with some aspects of AD genetics (e.g., MAPT haplotypes) but diverges with respect to others (e.g., APOE genotype).
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Investigator: Alison Goate
Project Title: Molecular correlates of Alzheimer’s neuropathology in non-demented individuals
Date: December 21, 2021 at 5:02 pm
Request ID: T1511
Aim 1: Identify gene expression and DNA methylation correlates of amyloid plaques, neurofibrillary tangles, and cell numbers in non-demented individuals
Aim 2: Identify microglial-specific molecular correlates of Alzheimer�s neuropathology in non-demented individuals
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Investigator: Celeste Karch
Project Title: PLD3 function in the lysosome
Date: December 21, 2021 at 5:02 pm
Request ID: T1413-A
Aim 1: To determine whether PLD3 risk variants alter PLD3 localization and/or lysosomal function in human brains
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Investigator: John Morris/Nigel Cairns
Project Title: Multimodal Characterization of Hippocampal Sclerosis
Date: December 21, 2021 at 5:02 pm
Request ID: T1510
Aim 1: determine the distinguishing immunohistochemical features of HS in comparison with AD and normal aging (to include stereological assessment of neuronal loss across the entire hippocampus into the entorhinal cortex; TDP43 severity, distribution, and type of inclusions; gliosis; concomitant pathologi
Aim 2: is to determine the clinical features of HS as distinguished from AD and aging
Aim 3: determine the distinguishing biomarker features (MRI; CSF; etc) of HS in comparison with AD and aging
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Investigator: Sherry Ferguson
Project Title: Alzheimer�s disease (AD) in African Americans and Caucasians: Comparisons of biomarkers of inflammation in human tissues.
Date: December 21, 2021 at 5:02 pm
Request ID: T1509
Aim 1: Determine race-related differences in cytokine profiles of African Americans and Caucasians with AD
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