The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Dr. Venkata Mattay
Project Title: Identifying molecular mechanisms underlying resilience to the neuropathological hallmarks of Late-onset Alzheimer�s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1603
Aim 1: Determine cognitive resilience relevant biological pathways significantly enriched with genes (whole transcript, exon and exon junctions) that are differentially expressed between ADPC and LOAD patients
Aim 2: Explore an epigenetic basis for resilience factors by identifying differentially methylated genetic regions (DMRs) at CpGs between LOAD and ADPC brains
Aim 3:
Aim 4:
Investigator: Sally Temple
Project Title: iPSC Line Generation to Develop the Tau Consortium Collection
Date: December 21, 2021 at 5:02 pm
Request ID: T1506
Aim 1: To generate iPSC from MAPT mutation carriers and related non-carriers
Aim 2:
Aim 3:
Aim 4:
Investigator: Chihiro Sato
Project Title: Tau Kinetics in the Human CNS
Date: December 21, 2021 at 5:02 pm
Request ID: T1609 Sato_Bateman
Aim 1: To assess tau labeling in the human brain 8 days post-mortem
Aim 2:
Aim 3:
Aim 4:
Investigator: Feng Lin
Project Title: New biomarkers for Alzheimer’s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1608
Aim 1: We will analyze CSF samples from control and Alzheimer’s Disease patients to identify potential new biomarkers for future better dignosis of Alzheimer’s Disease
Aim 2:
Aim 3:
Aim 4:
Investigator: Kelly R. Bales
Project Title: Cerebrospinal Fluid Request
Date: December 21, 2021 at 5:02 pm
Request ID: T1607
Aim 1: cross sectional analysis of CSF Ab42:37 ratio across AD continuum (see below for cohort details)
Aim 2: longitudinal analysis of CSF Ab42:37 ratio in subjects that convert to AD (see below for cohort details)
Aim 3:
Aim 4:
Investigator: NK Robakis
Project Title: PS1 Regulates Processing and Signaling of EphrinB/EphB
Date: December 21, 2021 at 5:02 pm
Request ID: T1508
Aim 1: Effects of PS1 FAD mutants on neuronal survival compolexes formed between tyrosine kinase receptors (such as EphB and Trk), PS1 and NR1 compared to normal controls.
Aim 2: Effects of PS1 FAD mutations on brain miR-212 and target protein PED/PEA15 compared to cognitively normal controls.
Aim 3:
Aim 4:
Investigator: Anne Fagan
Project Title: Lumipulse Automated CSF Assay for Ab42 and tau
Date: December 21, 2021 at 5:02 pm
Request ID: T1605
Aim 1: To test Lumipulse CSF Ab42 and tau methodologic assay performance
Aim 2: To compare CSF biomarker profiles between African Americans and European Americans
Aim 3: To evaluate the correspondence between Lumipulse Ab42 and cortical amylioid load defined by PIB PET
Aim 4:
Investigator: Tammie L.S. Benzinger
Project Title: quantification of neuroinflammation and neurodegeneration in AD using DBSI
Date: December 21, 2021 at 5:02 pm
Request ID: T1604
Aim 1: Validate DBSI as a biomarker of neuroinflammation in AD
Aim 2: Validate DBSI as neurodegeneration markers in AD
Aim 3:
Aim 4:
Investigator: Sherry Ferguson
Project Title: Alzheimer�s disease (AD) in African Americans and Caucasians: Comparisons of biomarkers of inflammation in human tissues.
Date: December 21, 2021 at 5:02 pm
Request ID: T1509
Aim 1: Determine race-related differences in cytokine profiles of African Americans and Caucasians with AD
Aim 2:
Aim 3:
Aim 4:
Investigator: Beth Stevens
Project Title: of Microglia and Complement in Synapse Loss in Alzheimer�s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1715
Aim 1: Examine synapse-associated complement proteins in human AD tissue
Aim 2: Examine synaptic proteins inside microglia in human AD tissue
Aim 3:
Aim 4: