The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: J. Randall Slemmon Ph.D.
Project Title: Tau Fragment CSF Biosignature in AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1613
Aim 1: Determine if the pTau fragment profile changes in CSF during the course of AD.
Aim 2: Determine if the totalTau fragment profile (mid-mid region) changes in CSF during the course of AD.
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Investigator: A Fagan
Project Title: Prospective Measures of Outcome in Rapidly Progressive Dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1614
Aim 1: Determine clinically-measurable variables that differentiate between patients with various forms of RPD
Aim 2: Quantify neuroinflammation, neurodegeneration, and synaptic dysfunction in patients with RPD utilizing cerebrospinal fluid measures
Aim 3: Evaluate associations between biomarkers (Aim 2) and clinical outcomes (including cognitive performance) measured in individuals with RPD
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Investigator: Eric McDade, DO
Project Title: DIAN Expanded Registry: Exploratory Genetic Counseling and Testing (GCT) Program
Date: December 21, 2021 at 5:02 pm
Request ID: T1615
Aim 1: Identify families that carry autosomal dominant mutations on PS1, PS2, APP
Aim 2: Identify novel genes that cause Alzheimer’s disease
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Investigator: Dr Raffaele Ferrari
Project Title: Genomics studies of Frontotemporal Dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1617
Aim 1: Generate genotyping data for cases diagnosed with frontotemporal dementia
Aim 2: Perform association and rare variants analyses for novel disease-associated loci and genes discovery
Aim 3: Provide back raw genotyping data once generated
Aim 4: Possibly use DNA for validating results using Sanger or next generation sequencing techniques
Investigator: Sumit Sarkar
Project Title: Study of vascular dysfunction in brain of two transgenic rodent models of Alzheimer�s disease (AD): dietary impact and relevance to human AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1616
Aim 1: Determine the contribution of neurovascular units (endothelial cells, astrocytes, pericytes, microglia, and basement membranes) and associated cerebrovascular integrity in the deposition of microvascular and/or parenchymal amyloid beta (A�) and/or abnormal tau protein in two rodent models of AD
Aim 2: Attempt to accelerate AD pathology through high fat diet-induced obesity in the AD Tg rat and Tg-SwDI (cerebral amyloid angiopathy; CAA) mouse models of AD
Aim 3: Correlate findings from specific aims 1 and 2 with human brain tissue to further explore whether Aß and/or hyperphosphorylated-tau (p-tau) contribute to endothelial dysfunction, increase BBB permeability and lead to neuronal degeneration
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Investigator: Dr. Rosa Rademakers
Project Title: Whole-genome sequencing in FTLD-TDP patients
Date: December 21, 2021 at 5:02 pm
Request ID: T1618
Aim 1: Discovery of novel genetic elements associated with FTLD-TDP
Aim 2: Replication and characterization of novel genetic elements associated with FTLD-TDP
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Investigator: Emmanuel Mignot
Project Title: Analysis of hypocretin/orexin and other biomarkers in the cerebrospinal fluid of Alzheimer and controls patients and for Genome-wide association analysis
Date: December 21, 2021 at 5:02 pm
Request ID: T1619 Mignot
Aim 1: To study the differences of hypocretin metabolism in AD patients vs. controls both at the physiological and at the genetic level
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Investigator: G. William Rebeck
Project Title: APOE ISOFORM-SPECIFIC GLYCOSYLATION IN ALZHEIMER�S DISEASE; addendum
Date: December 21, 2021 at 5:02 pm
Request ID: T1611-A
Aim 1: Test APOE modifications as biomarkers of AD
Aim 2: Define how APOE modifications affect APOE metabolism across tissues
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Investigator: G. William Rebeck
Project Title: APOE ISOFORM-SPECIFIC GLYCOSYLATION IN ALZHEIMER�S DISEASE
Date: December 21, 2021 at 5:02 pm
Request ID: T1611
Aim 1: identify glycosylated forms of APOE in human plasma
Aim 2: determine whether plasma glyco-APOE species differ by APOE genotype
Aim 3: determine whether plasma glyco-APOE species are altered in Alzheimer’s disease
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Investigator: David Holtzman
Project Title: Establishment of a new tau pathology seeding model for investigating the role of amyloid in microglia in tau spreading
Date: December 21, 2021 at 5:02 pm
Request ID: T1702
Aim 1: Replicate the pathological seeding of endogenous mouse tau using tau from human AD brain
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