The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Carlos Cruchaga and Jin-Moo Lerr
Project Title: Contribution of vascular disease to Alzheimer dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1610
Aim 1: Aim 1: Develop precise imaging biomarker of vascular burden by identifying distinct white matter hyperintensity patterns that are highly correlated with cerebrovascular disease and/or vascular risk factors in a mixed cohort of AD, healthy aging and stroke patients.
Aim 2: Aim2: Validate the novel biomarker for stroke and vascular dementia.
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Investigator: Byron Caughey
Project Title: Development of tau RT-QuIC assays for tau oligomers with seeding activity
Date: December 21, 2021 at 5:02 pm
Request ID: T1703 Caughey
Aim 1: To develop seeded polymerization-based assay for tauopathy-associated tau aggregates.
Aim 2: To improve the sensitivity and specificity of tauopathy diagnostics.
Aim 3: To improve the detection of tau aggregates as biomarkers to facilitate therapeutic trials.
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Investigator: Kaj Blennow
Project Title: Plasma NFL as a biomarker for preclinical AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1704
Aim 1: Study plasma NFL as a predictor of progression in the preclinical stage
Aim 2: Study plasma NFL as a neurodegeneration biomarker in MCI
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Investigator: David Holtzman
Project Title: Establishment of a new tau pathology seeding model for investigating the role of amyloid in microglia in tau spreading
Date: December 21, 2021 at 5:02 pm
Request ID: T1702
Aim 1: Replicate the pathological seeding of endogenous mouse tau using tau from human AD brain
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Investigator: Dougherty
Project Title: Pilot test for sexual dimorphism in the human L.C.
Date: December 21, 2021 at 5:02 pm
Request ID: T1701
Aim 1: To determine feasibility of laser capture of locus coeruleus mRNA from male and female brain
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Investigator: G. William Rebeck
Project Title: APOE ISOFORM-SPECIFIC GLYCOSYLATION IN ALZHEIMER�S DISEASE; addendum
Date: December 21, 2021 at 5:02 pm
Request ID: T1611-A
Aim 1: Test APOE modifications as biomarkers of AD
Aim 2: Define how APOE modifications affect APOE metabolism across tissues
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Investigator: Fujirebio Diagnostics Inc
Project Title: Fujirebio ADRC Sample Request
Date: December 21, 2021 at 5:02 pm
Request ID: T1721
Aim 1: to establish a Lumipulse G β-Amyloid 1-42 assay cutoff for distinguishing AD vs. HC in an autopsy confirmed LOAD population with appropriate clinical data.
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Investigator: Chihiro Sato
Project Title: Quantitative analyses of tau phosphorylation and isoforms in Brain, CSF, and cell culture models
Date: December 21, 2021 at 5:02 pm
Request ID: T1722
Aim 1: To establish a comprehensive, quantitative profile of tau in human brain and CSF in AD and controls
Aim 2: To validate novel CSF tau phosphorylation ratios as new biomarkers of AD
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Investigator: Kevin Yarasheski
Project Title: Analytical validation & confirmation of a novel blood test for brain amyloidosis
Date: December 21, 2021 at 5:02 pm
Request ID: T1723
Aim 1: Conduct the analytical validation of a novel, quantitative mass spectrometry-based plasma A� isoform assay.
Aim 2: Confirm the ability of this novel assay to distinguish between people with/without brain amyloidosis.
Aim 3: Calculate the assay accuracy (ROC AUC) and threshold plasma A�42/A�40 ratio that distinguishes between brain amyloid positive vs negative.
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Investigator: Tammie Benzinger
Project Title: Quantification of Neuroinflammation inAlzheimer’s Disease Using Diffusion BasisSpectrum Imaging
Date: December 21, 2021 at 5:02 pm
Request ID: T1604-A
Aim 1: Validate DBSI as a biomarker of neuroinflammation in AD by using quantitative neuropathology.
Aim 2: Compare DBSI to PET biomarkers of neuroinflammation (DPA-7148, PBR289, PK1119510) and AD ([18F]-Florbetapir, [18F]-Flortaucipir).
Aim 3: Compare DBSI to CSF biomarkers of neuroinflammation (YKL4011 , sTREM212, 13) and AD (A�42, tau, p-tau)
Aim 4: Quantify cross sectional and longitudinal DBSI cell fraction in preclinical and early symptomatic AD and correlate with clinical outcomes (cognitive and progression).