The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Sumit Sarkar
Project Title: Study of vascular dysfunction in brain of two transgenic rodent models of Alzheimer�s disease (AD): dietary impact and relevance to human AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1616
Aim 1: Determine the contribution of neurovascular units (endothelial cells, astrocytes, pericytes, microglia, and basement membranes) and associated cerebrovascular integrity in the deposition of microvascular and/or parenchymal amyloid beta (A�) and/or abnormal tau protein in two rodent models of AD
Aim 2: Attempt to accelerate AD pathology through high fat diet-induced obesity in the AD Tg rat and Tg-SwDI (cerebral amyloid angiopathy; CAA) mouse models of AD
Aim 3: Correlate findings from specific aims 1 and 2 with human brain tissue to further explore whether Aß and/or hyperphosphorylated-tau (p-tau) contribute to endothelial dysfunction, increase BBB permeability and lead to neuronal degeneration
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Investigator: Dr. Rosa Rademakers
Project Title: Whole-genome sequencing in FTLD-TDP patients
Date: December 21, 2021 at 5:02 pm
Request ID: T1618
Aim 1: Discovery of novel genetic elements associated with FTLD-TDP
Aim 2: Replication and characterization of novel genetic elements associated with FTLD-TDP
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Investigator: Emmanuel Mignot
Project Title: Analysis of hypocretin/orexin and other biomarkers in the cerebrospinal fluid of Alzheimer and controls patients and for Genome-wide association analysis
Date: December 21, 2021 at 5:02 pm
Request ID: T1619 Mignot
Aim 1: To study the differences of hypocretin metabolism in AD patients vs. controls both at the physiological and at the genetic level
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Investigator: G. William Rebeck
Project Title: APOE ISOFORM-SPECIFIC GLYCOSYLATION IN ALZHEIMER�S DISEASE; addendum
Date: December 21, 2021 at 5:02 pm
Request ID: T1611-A
Aim 1: Test APOE modifications as biomarkers of AD
Aim 2: Define how APOE modifications affect APOE metabolism across tissues
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Investigator: Dougherty
Project Title: Pilot test for sexual dimorphism in the human L.C.
Date: December 21, 2021 at 5:02 pm
Request ID: T1701
Aim 1: To determine feasibility of laser capture of locus coeruleus mRNA from male and female brain
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Investigator: David Holtzman
Project Title: Establishment of a new tau pathology seeding model for investigating the role of amyloid in microglia in tau spreading
Date: December 21, 2021 at 5:02 pm
Request ID: T1702
Aim 1: Replicate the pathological seeding of endogenous mouse tau using tau from human AD brain
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Investigator: Kaj Blennow
Project Title: Plasma NFL as a biomarker for preclinical AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1704
Aim 1: Study plasma NFL as a predictor of progression in the preclinical stage
Aim 2: Study plasma NFL as a neurodegeneration biomarker in MCI
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Investigator: Byron Caughey
Project Title: Development of tau RT-QuIC assays for tau oligomers with seeding activity
Date: December 21, 2021 at 5:02 pm
Request ID: T1703 Caughey
Aim 1: To develop seeded polymerization-based assay for tauopathy-associated tau aggregates.
Aim 2: To improve the sensitivity and specificity of tauopathy diagnostics.
Aim 3: To improve the detection of tau aggregates as biomarkers to facilitate therapeutic trials.
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Investigator: Carlos Cruchaga and Jin-Moo Lerr
Project Title: Contribution of vascular disease to Alzheimer dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1610
Aim 1: Aim 1: Develop precise imaging biomarker of vascular burden by identifying distinct white matter hyperintensity patterns that are highly correlated with cerebrovascular disease and/or vascular risk factors in a mixed cohort of AD, healthy aging and stroke patients.
Aim 2: Aim2: Validate the novel biomarker for stroke and vascular dementia.
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Investigator: Sally Temple/Celeste Karch
Project Title: iPSC Modeling of AD Using Progerin
Date: December 21, 2021 at 5:02 pm
Request ID: T1720
Aim 1: Is prelamin A expression and processing perturbed in AD brains?
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