The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Kenneth S. Kosik
Project Title: Gene expression analysis of MAPT mutation carriers
Date: December 21, 2021 at 5:02 pm
Request ID: T1407
Aim 1: Transcriptome sequencing for RNA obtained from neurons derived from iPS patients
Aim 2: Comparison of differentially expressed genes compared to human healthy lines and tissue
Aim 3: miRNA profiling of these samples as in 1
Aim 4: Determination of coexpression modules associated with the MAPT mutations
Investigator: Dr. Tom Montine
Project Title: : Neuropathological assessments of fibrillar amyloid burden in APOE e4 carriers and non-carriers with the clinical diagnosis of Alzheimer’s dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1406
Aim 1: . In this study, NACC data will be used to compare the proportions of expired brain donors with the clinical diagnosis of Alzheimer’s dementia in terms of their fibrillar amyloid burden and other neuropathologic features
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Investigator: Eric J Kremer
Project Title: Screen for a biomarker in early satges of late-onset AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1405
Aim 1: Screen CSF from AD patients for the presence of a cleaved presynaptic protein diminished in early satges of late onset AD
Aim 2: Screen AD SGZ for the presence of a cell adhesion molecule diminished in early satges of late onset AD
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Investigator: Cruchaga/Sands
Project Title: Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance (Amendment)
Date: December 21, 2021 at 5:02 pm
Request ID: T1108-A
Aim 1: to identify the causative variant of Kufs’ disease
Aim 2: to characterize the causative mutations
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Investigator: Kukull (Penn)
Project Title: Validation of non-amyloid, non-Tau CSF biomarkers of Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1403
Aim 1: Aim 1: We will validate 12 non-amyloid, non-Tau CSF biomarkers of AD in samples from subjects with normal cognition, AD, and non-AD dementias, longitudinally followed at the three Centers (WU, Penn, Emory).
Aim 2: Aim 2: We will identify non-amyloid, non-Tau biomarkers suitable as staging and progression biomarkers in AD, evaluate their specificity for AD vs non-AD dementias, and evaluate the technical variability of the relevant assays across three independent Centers.
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Investigator: RJ Bateman
Project Title: Bioanalytical Assay Method Validation for Alzheimer�s Disease Clinical Trials
Date: December 21, 2021 at 5:02 pm
Request ID: T1418
Aim 1: To create pools of CSF to be used to conduct full bioanalytical method validation on the INNO-BIA AlzBio3 assay for use in clinical trials
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Investigator: John A. Kessler
Project Title: Cell autonomous mechanisms of Apolipoprotein E isoform-dependent neurodegeneration
Date: December 21, 2021 at 5:02 pm
Request ID: T1424
Aim 1: Generate isogenic APOE iPSCs from sporadic AD patients and healthy controls.
Aim 2: Evaluate whether calcium dysregulation contributes to increased excitotoxic response in E4- BFCNs.
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Investigator: Marni Uger PhD
Project Title: CSF Abeta oligomer quantification by EP-AD, a novel proprietary assay
Date: December 21, 2021 at 5:02 pm
Request ID: T1425
Aim 1: EP-AD CSF oligomers in AD, MCI and cognitively normal aging
Aim 2: EP-AD CSF oligomer concentration and cognitive, imaging, and biochemical biomarker correlation
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Investigator: Rosa Rademakers
Project Title: Identification of new genetic causes of Early Onset Alzheimer Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1501
Aim 1: Genetic screening of early onset alzheimer disease patients
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Investigator: Kelvin Yamada
Project Title: CSF orexin in postmenopausal insomnia
Date: December 21, 2021 at 5:02 pm
Request ID: T1502
Aim 1: Determine if CSF orexin is elevated in postmenopausal women
Aim 2: Determine if CSF orexin levels by ELISA are accurately reflected by serum orexin levels
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