The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Jason Hassenstab
Project Title: Predictors and Outcomes of Clinical Dementia Rating Reversion
Date: [153]
Request ID: D1526
Aim 1: To determine if reversion to normal cognition (CDR 0) following an initial diagnosis of dementia (CDR >0) is related to CSF biomarkers, cortical amyloid tracer uptake, brain structure, and cognitive performance.
Aim 2: To determine if reversion to normal cognition is related to future progression to CDR >0 and to determine if this relationship is moderated by CSF and imaging biomarkers of AD.
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Investigator: Dmitriy Yablonskiy
Project Title: Quantitative Evaluation of Changes in the AD brain Using Advanced MRI
Date: [153]
Request ID: D1525
Aim 1: To compare GEPCI measurements with cortical and CSF amyloid-beta 42 measurements
Aim 2: To compare GEPCI measurements with tau, CSF tau and ptau measurements
Aim 3: To compare GEPCI measurements with objective meaure of cognition
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Investigator: Sarah Hartz
Project Title: Impact of returning cognitive status on participation in research studies
Date: [153]
Request ID: D1524
Aim 1: The aim of this study is to evaluate how returning cognitive status impacted subsequent participation in ADRC studies.
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Investigator: Dawn Matthews, MS MM
Project Title: Multimodality Imaging Diagnostic for Preclinical and Prodromal AD
Date: [153]
Request ID: D1523
Aim 1: Further evaluate and develop the use of early frame amyloid data as a marker of disease and predictor of functional change
Aim 2: Refine and validate PET and structural MRI classifiers in differentiating amyloid positive and negative populations and predicting rate of clinical decline.
Aim 3: Compare florbetapir PET and PiB PET data including use of early frames for functional measurement and pre-equilibrium amyloid burden measurement.
Aim 4: Optimize processing and classification approaches to functional MRI data to characterize disease state and progression
Investigator: Samantha Allison
Project Title: Relationships between Alzheimer’s disease biomarkers and self-reported navigation skill
Date: [153]
Request ID: D1522
Aim 1: Examine relationships between Alzheimer’s disease biomarkers (e.g., CSF abeta, tau, ptau) and self-reported navigation performance
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Investigator: Samantha Allison
Project Title: Effects of Preclinical Alzheimer�s Disease Along the Longitudinal Axis of the Hippocampus
Date: [153]
Request ID: D1521
Aim 1: Assess the effects of CSF Aβ42, tau, and CSF ptau on the hippocampal body, head, and tail volumes
Aim 2: Assess the effect of PET-based measures of amyloid deposition on the hippocampal body, head, and tail volumes
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Investigator: Ram Bishnoi
Project Title: Cognitive, neuroimaging and histopathological correlates of neuropsychiatric symptoms in Alzheimer’s disease
Date: [153]
Request ID: D1520
Aim 1: To find out if certain demographic characteristics and cognitive abnormalities predispose the subject to neuropsychiatric symptoms
Aim 2: To ascertain if neuroimaging features (structural/functional) can differentiate subjects with and without neuropsychiatric symptoms
Aim 3: Is histopathology different among two groups mentioned above.
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Investigator: Sebastien Ourselin
Project Title: Validation of attenuation correction synthesis for PET-MR scanners
Date: [153]
Request ID: D1519
Aim 1: Validate a novel method of attenuation correction for PET-MR data by creating “pseudo-CT” images that are created based on information provided from a template library of co-registered MR and CT pairs.
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Investigator: Beau Ances
Project Title: The Influence of Traumatic Brain Injury on Anatomical Morphometry in Alzheimer’s Disease
Date: [153]
Request ID: D1518
Aim 1: Are hippocampal volumes different cross-sectionally between AD patients with and without the presence of a TBI and LOC?
Aim 2: Is the degenerative component for AD patients with a TBI and LOC
Aim 3: Longitudinally, is the AD progression more drastic in patients who experienced a TBI with LOC compared to AD patients without a TBI
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Investigator: Lenise Cummings-Vaughn
Project Title: Exploring AD Biomarker Disparities Between African Americans and European Americans
Date: [153]
Request ID: D1517
Aim 1: Determine whether Alzhemer Disease (AD) biomarker abnormalities vary as a function of race or ethnicity
Aim 2: Determine if African Americans with preclinical AD have a higher frequency of cerebrovascular lesions.
Aim 3: Determine if African Americans with preclinical AD have higher frequency of hypovitaminosis D.
Aim 4: Determine if African Americans with preclinical AD have a higher frequency of chronic inflammation.