The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Mark McDaniel
Project Title: The Effects of Hypertension and Abnormal Blood Pressure on Prospective Memory
Date: December 21, 2021 at 5:18 pm
Request ID: D1108
Aim 1: Assess the effects of hypertension on focal versus nonfocal prospective memory (PM) performance
Aim 2: Determine whether gray matter volume mediates the relationship between hypertension and PM
Aim 3: Determine whether white matter integrity relates to focal PM, nonfocal PM, or hypertension
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Investigator: Williams, Monique
Project Title: Vascular Risk Factors in Alzheimer Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D0816
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Investigator: Luigi Maccotta
Project Title: Functional Connectivity in Epilepsy
Date: December 21, 2021 at 5:18 pm
Request ID: D1103
Aim 1: To characterize changes in local and long-range functional connections in temporal lobe epilepsy
Aim 2: To characterize connectivity changes in TLE patients with grossly normal brain anatomy
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Investigator: Gina D’Angelo
Project Title: Missing data approaches for partial correlations of regional volumetric data
Date: December 21, 2021 at 5:18 pm
Request ID: D1025
Aim 1: Extend the partial correlation coefficient in the presence of missing data using the EM algorithm
Aim 2: Use (1) to study relationships among regional brain measures while adjusting for other variables
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Investigator: B. Joy Snider
Project Title: Genotype-Phenotype Correlations in Dominantly Inherited Dementing Disorders
Date: December 21, 2021 at 5:18 pm
Request ID: D1026
Aim 1: Look for correlations between clinical phenotype with mutation in those with known mutation
Aim 2: look for correlation between rate of progression and mutation
Aim 3: preliminary analysis of biomarkers in known mutations
Aim 4: preliminary analysis of PET_PIB in known mutations
Investigator: Roe, Catherine
Project Title: Memory Complaints in Individuals without Cognitive Impairment
Date: December 21, 2021 at 5:18 pm
Request ID: D0812
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Investigator: David B. Carr, MD
Project Title: Functional Impairment in PIB+ Healthy Older Adults
Date: December 21, 2021 at 5:18 pm
Request ID: D1101
Aim 1: Is there a lower prevalence of active drivers in PIB+ CDR=0 participants?
Aim 2: Of the active driver pool, are PIB+ CDR=0 drivers believed to be at more risk than PIB-?
Aim 3: Is functional impairment (FAQ) more prevalent in PIB+ CDR=0 participants?
Aim 4: Do PIB+ CDR=0 participants have a higher rate of functional decline over time?
Investigator: Dr. Denise Head
Project Title: Effects of the BDNF polymorphism and exercise on brain structure, AD biomarkers and cognition.
Date: December 21, 2021 at 5:18 pm
Request ID: D1102
Aim 1: examine the effects of the BDNF polymorphism on brain, cognition, and AD biomarkers
Aim 2: examine interactions between the BDNF polymorphism and exercise
Aim 3: examine interactions between the BDNF polymorphism and age
Aim 4: examine interactions between the APOE and BDNF polymorphisms
Investigator: Dr. John Morris
Project Title: Age of Onset Disparities among first degree relatives
Date: December 21, 2021 at 5:18 pm
Request ID: D1104
Aim 1: To determine the causes for AOO disparities among first degree relatives
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Investigator: Catherine M. Roe
Project Title: IMPROVING PRESYMPTOMATIC DETECTION OF IMPENDING ALZHEIMER’S DISEASE
Date: December 21, 2021 at 5:18 pm
Request ID: D1105
Aim 1: To examine how cognitive and brain reserve factors combine with AD biomarkers
Aim 2: To build biomarker models that yield individual risk profiles predicting the time of AD onset.
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