The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: CAMD consortium
Project Title: CAMD request for biomarker data
Date: December 21, 2021 at 5:18 pm
Request ID: D1319
Aim 1: FDA biomarker qualification
Aim 2: Alzheimer’s disease progression modeling
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Investigator: John C Morris
Project Title: Accelerators and Protectors of Tranistioning to Symptomatic AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1424
Aim 1: Examine Adult Choildren Study participants who have been rated CDR>0
Aim 2: Compare their clinical, cognitive, imaging, biofluid, and genetic features with ACS participants who remain CDR0
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Investigator: Meghan Mattos
Project Title: Mild Cognitive Impairment in Older, Rural dwelling Adults
Date: December 21, 2021 at 5:18 pm
Request ID: D1502
Aim 1: Compare MCI symptom severity among older rural and non-rural adults
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Investigator: Tammie Benzinger
Project Title: NIA-AA staging in preclinical Alzheimer disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1503
Aim 1: classify individuals based upon NIA-AA stages using CSF biomarkers
Aim 2: classify individuals based upon NIA-AA stages using PET and MRI data
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Investigator: Joan Montaner
Project Title: A NEW CHEMOKINE (CCL23) TO PREDICT MILD COGNITIVE IMPAIRMENT PROGRESSION TO ALZHEIMER DISEASE
Date: December 21, 2021 at 5:18 pm
Request ID: D1508
Aim 1: We aimed to evaluate the predictive value of CCL23 in patients with mild cognitive impairment that would develop dementia
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Investigator: Yvette Sheline
Project Title: Comparison of graph characteristics in resting state fMRI in LOAD and DIAN participants
Date: December 21, 2021 at 5:18 pm
Request ID: D1504
Aim 1: Determine graph characteristics (wavelet-based coherence, binary graph diagnostics, weighted and cynamic graph diagnostics in LOAD and DIAN
Aim 2: Determine similarities and differences in these graph characteristics
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Investigator: hugo vanderstichele
Project Title: CSF Biomarker analysis for to the Adult Children Study (ACS) of the Knight Alzheimer�s Disease Research Center at Washington (recently published by JAMA NEUROLOGY)
Date: December 21, 2021 at 5:18 pm
Request ID: D1510
Aim 1: AD CSF biomarker changes in cognitively normal middle-aged adults
Aim 2: Performance of individual biomarkers or combinations of biomarkers
Aim 3: Comparison of biomarkers with imaging data
Aim 4: Evaluate correlation between CSF biomarkers and cognitive performance
Investigator: Catherine Roe
Project Title: Pilot data for Sleep Aim of Preclinical AD and Driving Continuing Renewal
Date: December 21, 2021 at 5:18 pm
Request ID: D1509
Aim 1: To combine data from HASD Project 2 (Sleep study) with data from R01 AG043434-01 (Preclinical AD and Driving) for pilot data to be used in the R01 Continuing Renewal application.
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Investigator: Julia Soscia
Project Title: An item-level analysis of frequently missed items on the Mini Mental State Exam (MMSE) in cognitively normal older adults and its relationship to future cognitive impairment.
Date: December 21, 2021 at 5:18 pm
Request ID: D1505
Aim 1: To determine which MMSE items predict future cognitive problems
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Investigator: Linda Larson-Prior
Project Title: Changes in Brain Network dynamics As An Index of Amyloid Status in Healthy Elders
Date: December 21, 2021 at 5:18 pm
Request ID: D1507
Aim 1: Under the hypothesis that cognitively normal individuals with either abnormal CSF protein levels of Ab/tau an imaging evidence of amyloid load will exhibit abnormalities in regional and spectral-band specific neuronal synchronization, we will collect high density electroencephalography (hd-EEG, 256
Aim 2: Under the hypothesis that early markers of impairment in working memory will manifest in frontal synchrony measured in the theta band as well as in network synchrony assessed using phase locking value, we will collect hdEEG as subjects perform a visual N-back working memory task that includes emotio
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