The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: B. Joy Snider, Anne Fagan
Project Title: CSF biomarkers and rate of cognitive decline in very mild DAT
Date: December 21, 2021 at 5:18 pm
Request ID: D1117
Aim 1: Look for correlation between CSF biomarkers and rate of decline in very mild DAT
Aim 2: look for correlation between ApoE genotype and rate of decline in very mild DAT
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Investigator: Joel Perlmutter
Project Title: Effects of Parkinson’s Disease on BOLD Functional Connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1118
Aim 1: Study effects of PD on BOLD FC in subcortical areas
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Investigator: Jessica Nichols (student in Friedman Program)
Project Title: Effect of Type 2 Diabetes Mellitus on Resting State Functional Connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1120
Aim 1: look at how T2DM affects resting state functional connectivity and if it is a risk factor for AD
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Investigator: Robyn A Honea
Project Title: The Role of Genetic Variation in Alzheimer’s Disease Neurodegeneration
Date: December 21, 2021 at 5:18 pm
Request ID: D1121
Aim 1: Assess the relationship of selected candidate genes with MRI phenotypes and cognitive markers of AD
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Investigator: Joanne Conover
Project Title: Ventricular Expansion and Leakiness in Normal Aging
Date: December 21, 2021 at 5:18 pm
Request ID: D1122
Aim 1: Regional Trends in Expansion and Hyperintensities Using FLAIR-MRI
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Investigator: Dr. John C. Morris
Project Title: The rule of sleep, personality, and aging: How these interactions affect cognition
Date: December 21, 2021 at 5:18 pm
Request ID: D1119
Aim 1: When comparing CDR 0 to CDR 0.5, 0.5’s would have higher levels of neuroticism & sleep difficulties
Aim 2: Within CDR0, those with high neuroticism & sleep difficulties will have lower cognition performance
Aim 3: Of those who progress to higher CDR, more of the high neuroticism and sleep problems group
Aim 4: High neuroticism group show more awakening and activity on actigraphs
Investigator: Chengjie Xiong
Project Title: Two Preclinical Latent Scores to Predict Occurrence of DAT
Date: December 21, 2021 at 5:18 pm
Request ID: D1206
Aim 1: Assess the antecedent longitudinal changes and their predictive power of DAT for individual items of
Aim 2: Aim 2. Evaluate the use of IRT
Aim 3: Develop clinically meaningful score reports
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Investigator: Catherine M. Roe
Project Title: Alzheimer’s disease biomarkers and cancer
Date: December 21, 2021 at 5:18 pm
Request ID: D1207
Aim 1: To examine whether Alzheimer’s disease biomarkers are associated with cancer
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Investigator: Zheyu Wang
Project Title: Biomarker Evaluation in the Absence of a Gold Standard
Date: December 21, 2021 at 5:18 pm
Request ID: D1208
Aim 1: Methodology development on evaluating biomarkers in the absence of a gold standard
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Investigator: Phillip Hsu
Project Title: Risk factors associated with Headache due to Lumbar Puncture
Date: December 21, 2021 at 5:18 pm
Request ID: D1209
Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache
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