The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Yvette Sheline
Project Title: Comparison of graph characteristics in resting state fMRI in LOAD and DIAN participants
Date: December 21, 2021 at 5:18 pm
Request ID: D1504
Aim 1: Determine graph characteristics (wavelet-based coherence, binary graph diagnostics, weighted and cynamic graph diagnostics in LOAD and DIAN
Aim 2: Determine similarities and differences in these graph characteristics
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Investigator: Ram Bishnoi
Project Title: Cognitive, neuroimaging and histopathological correlates of neuropsychiatric symptoms in Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1520
Aim 1: To find out if certain demographic characteristics and cognitive abnormalities predispose the subject to neuropsychiatric symptoms
Aim 2: To ascertain if neuroimaging features (structural/functional) can differentiate subjects with and without neuropsychiatric symptoms
Aim 3: Is histopathology different among two groups mentioned above.
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Investigator: Beau Ances
Project Title: The Influence of Traumatic Brain Injury on Anatomical Morphometry in Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1518
Aim 1: Are hippocampal volumes different cross-sectionally between AD patients with and without the presence of a TBI and LOC?
Aim 2: Is the degenerative component for AD patients with a TBI and LOC
Aim 3: Longitudinally, is the AD progression more drastic in patients who experienced a TBI with LOC compared to AD patients without a TBI
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Investigator: Lenise Cummings-Vaughn
Project Title: Exploring AD Biomarker Disparities Between African Americans and European Americans
Date: December 21, 2021 at 5:18 pm
Request ID: D1517
Aim 1: Determine whether Alzhemer Disease (AD) biomarker abnormalities vary as a function of race or ethnicity
Aim 2: Determine if African Americans with preclinical AD have a higher frequency of cerebrovascular lesions.
Aim 3: Determine if African Americans with preclinical AD have higher frequency of hypovitaminosis D.
Aim 4: Determine if African Americans with preclinical AD have a higher frequency of chronic inflammation.
Investigator: Sebastien Ourselin
Project Title: Validation of attenuation correction synthesis for PET-MR scanners
Date: December 21, 2021 at 5:18 pm
Request ID: D1519
Aim 1: Validate a novel method of attenuation correction for PET-MR data by creating “pseudo-CT” images that are created based on information provided from a template library of co-registered MR and CT pairs.
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Investigator: Angela Curl
Project Title: Psychometric Testing of the CARS Instrument
Date: December 21, 2021 at 5:18 pm
Request ID: –
Aim 1: To test the psychometric reliability of the newly developed CARS Instrument
Aim 2: To test the psychometric validity of the newly developed CARS Instrument
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Investigator: Kirchhoff
Project Title: An Investigation of the Relationships Between Brain Structure and Attentional Control
Date: December 21, 2021 at 5:18 pm
Request ID: D1516
Aim 1: To identify brain regions that support successful attentional control processes by examining the relationships between brain structure and performance on attentional control tasks.
Aim 2: To investigate the brain structural changes that lead to attentional control impairments in Alzheimer�s Disease.
Aim 3: To examine whether brain structure at least partially mediates the relationships between AD risk and attentional control.
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Investigator: Zehra Onen
Project Title: Optimal Population Screening Policies for Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1514
Aim 1: To compute optimal population screening policies for Alzheimer�s Disease (AD) using Markov Decision Process (MDP) and Partially Observable MDP models.
Aim 2: To compute annual transition probabilities within AD free and preclinical stage individuals
Aim 3: To build mathematical models for biomarkers’ progression focusing on normal individuals and individuals in preclinical stages of Alzheimer’s Disease
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Investigator: GS Day
Project Title: Evaluating the impact of medications in Alzheimer disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1513
Aim 1: 1. Determine whether medications previously associated with cognitive impairment (i.e., offending medications) in cognitively normal individuals, associate with cognitive impairment in Memory and Aging Participants.
Aim 2: 2. Calculate the magnitude of effect of offending medication on participants with normal cognition, preclinical Alzheimer disease (AD) and symptomatic AD.
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Investigator: Linda Larson-Prior
Project Title: Changes in Brain Network dynamics As An Index of Amyloid Status in Healthy Elders
Date: December 21, 2021 at 5:18 pm
Request ID: D1507
Aim 1: Under the hypothesis that cognitively normal individuals with either abnormal CSF protein levels of Ab/tau an imaging evidence of amyloid load will exhibit abnormalities in regional and spectral-band specific neuronal synchronization, we will collect high density electroencephalography (hd-EEG, 256
Aim 2: Under the hypothesis that early markers of impairment in working memory will manifest in frontal synchrony measured in the theta band as well as in network synchrony assessed using phase locking value, we will collect hdEEG as subjects perform a visual N-back working memory task that includes emotio
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